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Journal Article > Research

High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010

Sanchez-Padilla E, Dlamini T, Ascorra A, Rusch-Gerdes S, Tefera ZD, Calain P, de la Tour R, Jochims F, Richter E, Bonnet MMB
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Abstract
In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009-2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking.
Subject Area
antibiotic resistancetuberculosisantimicrobial resistance
DOI
10.1111/j.1365-2648.2011.05934.x
Published Date
01-Jan-2012
PubMed ID
22260950
Languages
English
Journal
Emerging Infectious Diseases
Volume / Issue / Pages
Volume 68, Issue 1
Issue Date
01-Jan-2012
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