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Journal Article
|Research

Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings

Shanks L, Siddiqui MR, Abebe A, Piriou E, Pearce N, Ariti C, Masiga J, Muluneh L, Wazome JM, Ritmeijer KKD, Klarkowski DB
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Abstract
Current WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.

Countries

Ethiopia

Subject Area

diagnosticsHIV/AIDS

Languages

English
DOI
10.1186/s12985-015-0306-4
Published Date
14 May 2015
PubMed ID
25972188
Journal
Virology Journal
Volume | Issue | Pages
Volume 12, Issue 1
Issue Date
2015-05-14
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Dilution Testing Using Rapid Diagnostic Tests in a HIV Diagnostic Algorithm: a Novel Alternative for Confirmation Testing in Resource Limited Settings | Journal Article / Research | MSF Science Portal