Journal Article > ResearchFull Text
Virol J. 14 May 2015; Volume 12 (Issue 1); DOI:10.1186/s12985-015-0306-4
Shanks L, Siddiqui MR, Abebe A, Piriou E, Pearce N, et al.
Virol J. 14 May 2015; Volume 12 (Issue 1); DOI:10.1186/s12985-015-0306-4
Current WHO testing guidelines for resource limited settings diagnose HIV on the basis of screening tests without a confirmation test due to cost constraints. This leads to a potential risk of false positive HIV diagnosis. In this paper, we evaluate the dilution test, a novel method for confirmation testing, which is simple, rapid, and low cost. The principle of the dilution test is to alter the sensitivity of a rapid diagnostic test (RDT) by dilution of the sample, in order to screen out the cross reacting antibodies responsible for falsely positive RDT results.