Abstract
OBJECTIVES
3.1 PRIMARY OBJECTIVES
To estimate sero prevalence of anti-HEV antibodies (IgG and IgM) in different age groups in Am Timam, Chad 3.2
3.2 SECONDARY OBJECTIVES
• To determine individual risk factors associated with different anti-HEV antibody status during an acute outbreak;
• To determine household level risk factors associated with different anti-HEV antibody status during an acute outbreak;
• To compare the sero prevalence of anti-HEV antibodies (IgG and IgM) in different age groups at two different time periods during an acute HEV outbreak to inform our understanding of viral transmission dynamics in a population in this context;
• To determine sero prevalence in different age groups of other jaundice causing agents (malaria, hepatitis A, B and C, leptospirosis and arboviral diseases such as yellow fever, viral haemorrhagic fever, Dengue and Rift valley fever;
• To compare dried blood spots (DBS) with blood samples for detection of HEV IgM and IgG and HEV RNA through PCR;
• To compare oral swabs with blood samples for the detection of HEV IgM and IgG and HEV RNA through PCR. To determine individual risk factors associated with different anti-HEV antibody status during an acute outbreak;
To determine household level risk factors associated with different anti-HEV antibody status during an acute outbreak;
• To compare the sero prevalence of anti-HEV antibodies (IgG and IgM) in different age groups at two different time periods during an acute HEV outbreak to inform our understanding of viral transmission dynamics in a population in this context;
• To determine sero prevalence in different age groups of other jaundice causing agents (malaria, hepatitis A, B and C, leptospirosis and arboviral diseases such as yellow fever, viral hemorrhagic fever, Dengue and Rift valley fever;
• To compare dried blood spots (DBS) with blood samples for detection of HEV IgM and IgG and HEV RNA through PCR; • To compare oral swabs with blood samples for the detection of HEV IgM and IgG and HEV RNA through PCR.
