Journal Article
|ResearchMDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
Migliori GB, Tiberi S, Zumla A, Petersen E, Chakaya JM, Wejse C, Muñoz Torrico M, Duarte R, Alffenaar JWC, Schaaf HS, Marais BJ, Cirillo DM, Alagna R, Rendon A, Pontali E, Piubello A, Figueroa J, Ferlazzo G, García-Basteiro AL, Centis R, Visca D, DAmbrosio L, Sotgiu G, Arkub T, Akkerman OW, Aleksa A, Belilovski E, Bernal E, Blanc FX, Boeree M, Borisov S, Bruchfeld J, Cadiñanos Loidi J, Caminero JA, Carvalho A, Cebrian Gallardo J, Charalampos, Danila E, Davies Forsman L, Denholm JT, Dheda K, Diel R, Diktanas S, Dobler C, Enwerem M, Esposito S, Escobar Salinas N, Filippov A, Formenti B, García García J, Goletti D, Gomez Rosso R, Gualano G, Isaakidis P, Kaluzhenina A, Koirala S, Kuksa L, Kunst H, Li Y, Magis-Escurra C, Manfrin V, Manga S, Manika K, Marchese V, Martínez Robles E, Maryandyshev A, Matteelli A, Mariani A, Mazza-Stalder J, Mello F, Mendoza L, Mesi A, Miliauskas S, Mustafa Hamdan H, Ndjeka N, Nieto Marcos M, Ottenhoff T, Palmero D, Palmieri F, Papavasileiou A, Payen M, Pontarelli A, Pretti Dalcolmo M, Quirós Fernandez S, Romero R, Rossato Silva D, Santos ALS, Seaworth B, Sinitsyn M, Skrahina A, Solovic I, Spanevello A, Tadolini M, Torres C, Udwadia ZF, van den Boom M, Volchenkov G, Yedilbayev A, Zaleskis R, Zellweger JP
Abstract
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
Subject Area
Languages
English
