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Adapting to the global shortage of cholera vaccines: targeted single dose cholera vaccine in response to an outbreak in South Sudan | Journal Article / Commentary | MSF Science Portal
Journal Article
|Commentary

Adapting to the global shortage of cholera vaccines: targeted single dose cholera vaccine in response to an outbreak in South Sudan

Parker LA, Rumunu J, Jamet C, Kenyi Y, Lino RL, Wamala JF, Mpairwe AM, Ciglenecki I, Luquero FJ, Azman AS, Cabrol JC
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Abstract
Shortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive vaccination campaigns. Additionally, various epidemiological, political, and logistical challenges, which are poorly documented in the literature, often lead to delays in reactive campaigns, ultimately reducing the effect of vaccination. In June 2015, a cholera outbreak occurred in Juba, South Sudan, and because of the global shortage of oral cholera vaccine, authorities were unable to secure sufficient doses to vaccinate the entire at-risk population--approximately 1 million people. In this Personal View, we document the first public health use of a reduced, single-dose regimen of oral cholera vaccine, and show the details of the decision-making process and timeline. We also make recommendations to help improve reactive vaccination campaigns against cholera, and discuss the importance of new and flexible context-specific dose regimens and vaccination strategies.

Countries

South Sudan

Subject Area

vaccinationwater and sanitationoutbreakscholera

Languages

English
DOI
10.1016/S1473-3099(16)30472-8
Published Date
01 Apr 2017
PubMed ID
28109819
Journal
Lancet Infectious Diseases
Volume | Issue | Pages
Volume 17, Issue 4, Pages e123-e127
Issue Date
2017-04-01
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