Search Results | MSF Science Portal

Conference Material

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Poster

Grandesso F, Ouedraogo P, Issakha Diar MS, Hilario JS, Kouassi F, et al.

2024-05-23 • Epicentre Scientific Day 2024

Journal Article

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Pre-Print

Fuente IMdl, Benito MJS, Gisbert FB, García L, González V, et al.

2024-02-21 • Malaria Journal

BACKGROUND
Malaria genetic diversity is an important indicator of malaria transmission. Pfmsp1 and pfmsp2 are a frequent molecular epidemiology tool to assess the genetic diversity. ...

Journal Article

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Research

Molina-de la Fuente I, Sagrado Benito MJ, Lasry E, Ousley J, García L, et al.

2023-11-10 • Malaria Journal

BACKGROUND
Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly used in the Sahe...

Journal Article

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Research

Molina-de la Fuente I, Sagrado Benito MJ, Ousley J, Gisbert FdB, García L, et al.

2023-09-25 • American Journal of Tropical Medicine and Hygiene

Artemisinin-combined treatments are the recommended first-line treatment of Plasmodium falciparum malaria, but they are being threatened by emerging artemisinin resistance. Mutations in ...

Journal Article

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Research

Grais RF, Laminou IM, Woi-Messe LC, Makarimi R, Bouriema SH, et al.

2018-02-27 • Malaria Journal

BACKGROUND
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) w...

Journal Article

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Research

Smithuis FM, Shahmanesh M, Kyaw MK, Savran O, Lwin S, et al.

2004-11-01 • Tropical Medicine and International Health

Multi-drug resistant falciparum malaria is widespread in Asia. In Thailand, Cambodia and Vietnam the national protocols have changed largely to artesunate combined treatment regimens but...

Journal Article

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Research

Nwe TW, Oo T, Wai KT, Zhou SS, van Griensven J, et al.

2017-04-25 • Infectious Diseases of Poverty

BACKGROUND
This study examined evolving malaria profiles from January, 2010 to December, 2014 to evaluate achievements and challenges of implementing measures to prevent and control ...

Journal Article

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Research

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, et al.

2014-07-21 • American Journal of Tropical Medicine and Hygiene

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...

Journal Article

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Research

N'do S, Bandibabone JB, Soma DD, Musaka BZ, Prudhomme J, et al.

2021-11-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene

BACKGROUND
Insecticide resistance has become a widespread problem causing a decline in the effectiveness of vector control tools in sub-Saharan Africa. In this situation, ongoing mon...

Journal Article

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Research

Otienoburu SD, Maiga-Ascofare O, Schramm B, Jullien V, Jones JJ, et al.

2016-09-05 • Malaria Journal

BACKGROUND
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the differe...

Journal Article

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Research

Grandesso F, Guindo O, Woi-Messe LC, Makarimi R, Traore A, et al.

2018-01-25 • Malaria Journal

BACKGROUND
Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland S...

Journal Article

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Research

Maiga H, Lasry E, Diarra M, Sagara I, Bamadio A, et al.

2016-09-23 • PLOS One

BACKGROUND
Seasonal malaria chemoprevention (SMC) with sulphadoxine-pyrimethamine (SP) plus amodiaquine (AQ) is being scaled up in Sahelian countries of West Africa. However, the pot...

Journal Article

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Research

Maung TM, Oo T, Wai KT, Hlaing TM, Owiti P, et al.

2018-03-23 • Infectious Diseases of Poverty

BACKGROUND
Myanmar lies in the Greater Mekong Subregion where there is artemisinin-resistant Plasmodium falciparum malaria. As the artemisinin compound is the pillar of effective ant...

Journal Article

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Research

van Lenthe M, van der Meulen R, Lassovsky M, Ouabo A, Bakula E, et al.

2019-12-18 • Malaria Journal

BACKGROUND
Sulfadoxine–pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficac...

Journal Article

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Research

Kassaza K, Long AC, McDaniels JM, Andre M, Fredrickson W, et al.

2021-02-25 • Malaria Journal

BACKGROUND
Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt). Following CQ withdrawal for anti-malarial treatment, ...

Journal Article

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Research

Falq G, Van der Bergh R, de Smet M, Etienne W, Nguon C, et al.

2016-09-01 • Malaria Journal

BACKGROUND
In Cambodia, elimination of artemisinin resistance through direct elimination of the Plasmodium falciparum parasite may be the only strategy. Prevalence and incidence at d...

Journal Article

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Research

Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F, et al.

2008-08-09 • Malaria Journal

BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...

Journal Article

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Research

Bosman P, Stassijns J, Nackers F, Canier L, Kim N, et al.

2014-10-06 • Malaria Journal

BACKGROUND
Intensified efforts are urgently needed to contain and eliminate artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion. Médecins Sans Frontières plan...

Journal Article

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Research

Nash D, Nair SA, Mayxay M, Newton PN, Guthmann JP, et al.

2005-06-02 • Proceedings. Biological sciences / The Royal Society

Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is though...

Journal Article

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Research

Verschuere A, Decroo T, Lim D, Kindermans JM, Nguon C, et al.

2017-02-17 • Malaria Journal

BACKGROUND
Despite emerging drug resistance in Cambodia, artemisinin-based combination therapy (ACT) is still the most efficacious therapy. ACT is available free of charge in the Cam...

Science Portal

Les medicaments de la CPS sous la loupe

Genetic diversity and allelic variability of pfmsp1 y pfmsp2 of P. falciparum and its association with syntomatology and antimalarial drugs resistance markers in Yambio county, South Sudan

Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in South Sudan

Screening for K13-propeller mutations associated with artemisinin resistance in Plasmodium falciparum in Yambio County (Western Equatoria State, South Sudan)

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar

Malaria profiles and challenges in artemisinin resistance containment in Myanmar

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Insecticide resistance profiles in malaria vector populations from Sud-Kivu in the Democratic Republic of the Congo

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia

Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger

Seasonal malaria chemoprevention with sulphadoxine-pyrimethamine and amodiaquine selects pfdhfr-dhps quintuple mutant genotype in Mali

Assessment of household ownership of bed nets in areas with and without artemisinin resistance containment measures in Myanmar

Markers of sulfadoxine–pyrimethamine resistance in Eastern Democratic Republic of Congo; implications for malaria chemoprevention

Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern Uganda by high-resolution melt analysis

Assessing the asymptomatic reservoir and dihydroartemisinin-piperaquine effectiveness in a low transmission setting threatened by artemisinin resistant Plasmodium falciparum

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

Plasmodium prevalence and artemisinin-resistant falciparum malaria in Preah Vihear Province, Cambodia: a cross-sectional population-based study

Selection strength and hitchhiking around two anti-malarial resistance genes

Local constraints to access appropriate malaria treatment in the context of parasite resistance in Cambodia: a qualitative study