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Showing 1 - 20 of 54 Items
Showing 1 - 20 of 54 Items
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Research

Trends in Plasmodium falciparum resistance markers to sulfadoxine-pyrimethamine and amodiaquine over ten years of seasonal malaria chemoprevention in Moissala Health District, Chad

Grandesso F, Diar MSI, Kouassi F, Hilario JS, Ouedraogo P,  et al.
2025-12-31 • Malaria Journal
2025-12-31 • Malaria Journal

BACKGROUND

Seasonal Malaria Chemoprevention (SMC) has been implemented in Moissala Health District, southern Chad, since 2013 using the standard regimen of sulf...

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Neonatal and congenital malaria (NCM): a case series in the Tigray region, northern Ethiopia

Gebremichael YL, Hagos HH, Reta BK, Woldu TB, Berhe KR,  et al.
2025-07-01 • Malaria Journal
2025-07-01 • Malaria Journal

BACKROUND

Congenital malaria (CM) is the direct infection of a neonate with malaria parasites from their mother before or during birth. Neonatal malaria (NM) is...

Mixed-method evaluation study of a targeted mass drug administration of long-acting anti-malarials among children aged 3 months to 15 years in the Bossangoa sub-prefecture, Ouham, Central African Republic, during the COVID-19 pandemic

Robinson E, Ouabo A, Rose L, van Braak F, Vyncke J,  et al.
2024-05-15 • Malaria Journal
2024-05-15 • Malaria Journal
BACKGROUND
In 2020, during the COVID-19 pandemic, Médecins Sans Frontières (MSF) initiated three cycles of dihydroartemisin-piperaquine (DHA-PQ) mass drug administration (MDA) for ch...

Implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda: Stakeholder engagement meeting report

Hill J, Accrombessi M, Briand V, Dhabangi A, Hoyt J,  et al.
2024-03-27 • Malaria Journal
2024-03-27 • Malaria Journal

A Stakeholder engagement meeting on the implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda was held in Nairobi, Kenya, on 27 September...

Genetic diversity and allelic variability of pfmsp1 y pfmsp2 of P. falciparum and its association with syntomatology and antimalarial drugs resistance markers in Yambio county, South Sudan

Fuente IMdl, Benito MJS, Gisbert FB, García L, González V,  et al.
2024-02-21 • Malaria Journal
2024-02-21 • Malaria Journal
BACKGROUND
Malaria genetic diversity is an important indicator of malaria transmission. Pfmsp1 and pfmsp2 are a frequent molecular epidemiology tool to assess the genetic diversity. ...

Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in South Sudan

Molina-de la Fuente I, Sagrado Benito MJ, Lasry E, Ousley J, García L,  et al.
2023-11-10 • Malaria Journal
2023-11-10 • Malaria Journal
BACKGROUND
Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly used in the Sahe...

Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

WorldWide Antimalarial Resistance Network White Blood Cell Count in Malaria Study Group
2023-06-06 • Malaria Journal
2023-06-06 • Malaria Journal
BACKGROUND
The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count fr...

Investigating molecular mechanisms of insecticide resistance in the Eastern Democratic Republic of the Congo

Bandibabone JB, McLoughlin C, Ndo S, Bantuzeko C, Byabushi V,  et al.
2021-12-14 • Malaria Journal
2021-12-14 • Malaria Journal
BACKGROUND
Malaria vector control in the Democratic Republic of the Congo is plagued by several major challenges, including inadequate infrastructure, lack of access to health care s...

Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda

Oyet C, Roh ME, Kiwanuka G, Orikiriza P, Wade M,  et al.
2017-10-28 • Malaria Journal
2017-10-28 • Malaria Journal
BACKGROUND
Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained sett...

Low referral completion of rapid diagnostic test-negative patients in community-based treatment of malaria in Sierra Leone

Thomson A, Knogali M, de Smet M, Reid AJ, Mukhtar A,  et al.
2011-04-17 • Malaria Journal
2011-04-17 • Malaria Journal
BACKGROUND
Malaria is hyper-endemic and a major public health problem in Sierra Leone. To provide malaria treatment closer to the community, Médecins Sans Frontières (MSF) launched a...

Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

Gerstl S, Dunkley S, Mukhtar A, de Smet M, Baker S,  et al.
2010-01-21 • Malaria Journal
2010-01-21 • Malaria Journal
BACKGROUND
Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH...

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R,  et al.
2013-07-17 • Malaria Journal
2013-07-17 • Malaria Journal
BACKGROUND
Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.<...

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Grais RF, Laminou IM, Woi-Messe LC, Makarimi R, Bouriema SH,  et al.
2018-02-27 • Malaria Journal
2018-02-27 • Malaria Journal
BACKGROUND
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) w...

Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

Lynch E, Jensen TO, Assao B, Chihana ML, Turuho T,  et al.
2022-09-09 • Malaria Journal
2022-09-09 • Malaria Journal
BACKGROUND
Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein ...

Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

Van Malderen C, Van Geertruyden JP, Machevo S, Gonzalez R, Bassat Q,  et al.
2012-04-30 • Malaria Journal
2012-04-30 • Malaria Journal
BACKGROUND
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few ...

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B,  et al.
2012-05-03 • Malaria Journal
2012-05-03 • Malaria Journal
BACKGROUND
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, rando...

Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Ashley EA, Touabi M, Ahrer M, Hutagalung R, Htun K,  et al.
2009-10-27 • Malaria Journal
2009-10-27 • Malaria Journal
BACKGROUND: In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the...

Community participation during two mass anti-malarial administrations in Cambodia: lessons from a joint workshop

Peto TJ, Debackere M, Etienne W, Vernaeve L, Tripura R,  et al.
2018-01-27 • Malaria Journal
2018-01-27 • Malaria Journal
Two mass drug administrations (MDA) against falciparum malaria were conducted in 2015-16, one as operational research in northern Cambodia, and the other as a clinical trial in western C...

The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar

Smithuis FM, Kyaw MK, van der Broek I, Katterman N, Rogers C,  et al.
2013-10-11 • Malaria Journal
2013-10-11 • Malaria Journal
BACKGROUND
Insecticide-treated bed nets (ITN) reduce malaria morbidity and mortality consistently in Africa, but their benefits have been less consistent in Asia. This study's object...