Search Results | MSF Science Portal

Journal Article

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Research

Robinson E, Ouabo A, Rose L, van Braak F, Vyncke J, et al.

2024-05-15 • Malaria Journal

BACKGROUND
In 2020, during the COVID-19 pandemic, Médecins Sans Frontières (MSF) initiated three cycles of dihydroartemisin-piperaquine (DHA-PQ) mass drug administration (MDA) for ch...

Journal Article

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Pre-Print

Fuente IMdl, Benito MJS, Gisbert FB, García L, González V, et al.

2024-02-21 • Malaria Journal

BACKGROUND
Malaria genetic diversity is an important indicator of malaria transmission. Pfmsp1 and pfmsp2 are a frequent molecular epidemiology tool to assess the genetic diversity. ...

Journal Article

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Research

Molina-de la Fuente I, Sagrado Benito MJ, Lasry E, Ousley J, García L, et al.

2023-11-10 • Malaria Journal

BACKGROUND
Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SP-AQ), is a community-based malaria preventive strategy commonly used in the Sahe...

Journal Article

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Research

WorldWide Antimalarial Resistance Network White Blood Cell Count in Malaria Study Group

2023-06-06 • Malaria Journal

BACKGROUND
The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count fr...

Journal Article

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Research

Grout L, Katuala Givo Y, Newport T, Mahamat TA, Gitahi P, et al.

2023-02-06 • Malaria Journal

BACKGROUND
Angumu health zone in Ituri, Democratic Republic of Congo, is a highly malaria-endemic area with an overburdened health system and hosting internally displaced persons (ID...

Journal Article

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Research

Lynch E, Jensen TO, Assao B, Chihana ML, Turuho T, et al.

2022-09-09 • Malaria Journal

BACKGROUND
Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein ...

Journal Article

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Research

Bandibabone JB, McLoughlin C, Ndo S, Bantuzeko C, Byabushi V, et al.

2021-12-14 • Malaria Journal

BACKGROUND
Malaria vector control in the Democratic Republic of the Congo is plagued by several major challenges, including inadequate infrastructure, lack of access to health care s...

Journal Article

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Research

Oyet C, Roh ME, Kiwanuka G, Orikiriza P, Wade M, et al.

2017-10-28 • Malaria Journal

BACKGROUND
Early diagnosis of suspected malaria cases with a rapid diagnostic test (RDT) has been shown to be an effective malaria control tool used in many resource-constrained sett...

Journal Article

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Research

Gerstl S, Dunkley S, Mukhtar A, de Smet M, Baker S, et al.

2010-01-21 • Malaria Journal

BACKGROUND
Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH...

Journal Article

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Research

Grais RF, Laminou IM, Woi-Messe LC, Makarimi R, Bouriema SH, et al.

2018-02-27 • Malaria Journal

BACKGROUND
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) w...

Journal Article

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Research

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R, et al.

2013-07-17 • Malaria Journal

BACKGROUND
Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.<...

Journal Article

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Research

Thomson A, Knogali M, de Smet M, Reid AJ, Mukhtar A, et al.

2011-04-17 • Malaria Journal

BACKGROUND
Malaria is hyper-endemic and a major public health problem in Sierra Leone. To provide malaria treatment closer to the community, Médecins Sans Frontières (MSF) launched a...

Journal Article

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Research

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P, et al.

2009-08-23 • Malaria Journal

BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...

Journal Article

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Research

Ashley EA, Touabi M, Ahrer M, Hutagalung R, Htun K, et al.

2009-10-27 • Malaria Journal

BACKGROUND: In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the...

Journal Article

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Short Report

Peto TJ, Debackere M, Etienne W, Vernaeve L, Tripura R, et al.

2018-01-27 • Malaria Journal

Two mass drug administrations (MDA) against falciparum malaria were conducted in 2015-16, one as operational research in northern Cambodia, and the other as a clinical trial in western C...

Journal Article

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Research

Smithuis FM, Kyaw MK, van der Broek I, Katterman N, Rogers C, et al.

2013-10-11 • Malaria Journal

BACKGROUND
Insecticide-treated bed nets (ITN) reduce malaria morbidity and mortality consistently in Africa, but their benefits have been less consistent in Asia. This study's object...

Journal Article

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Research

Asito AS, Piriou E, Jura WGZO, Ouma C, Odada PS, et al.

2011-12-13 • Malaria Journal

BACKGROUND
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it...

Journal Article

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Research

Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B, et al.

2012-05-03 • Malaria Journal

BACKGROUND
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, rando...

Journal Article

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Research

Van Malderen C, Van Geertruyden JP, Machevo S, Gonzalez R, Bassat Q, et al.

2012-04-30 • Malaria Journal

BACKGROUND
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few ...

Journal Article

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Review

Cunningham J, Jones SM, Gatton ML, Barnwell JW, Cheng Q, et al.

2019-12-02 • Malaria Journal

Malaria rapid diagnostic tests (RDTs) emerged in the early 1990s into largely unregulated markets, and uncertain field performance was a major concern for the acceptance of tests for mal...

Science Portal

Mixed-method evaluation study of a targeted mass drug administration of long-acting anti-malarials among children aged 3 months to 15 years in the Bossangoa sub-prefecture, Ouham, Central African Republic, during the COVID-19 pandemic

Genetic diversity and allelic variability of pfmsp1 y pfmsp2 of P. falciparum and its association with syntomatology and antimalarial drugs resistance markers in Yambio county, South Sudan

Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in South Sudan

Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis

Effect of large-scale mass drug administration for malaria on mortality and morbidity in Angumu health zone, Ituri, Democratic Republic of Congo

Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

Investigating molecular mechanisms of insecticide resistance in the Eastern Democratic Republic of the Congo

Evaluation of the Deki Reader™, an automated RDT reader and data management device, in a household survey setting in low malaria endemic southwestern Uganda

Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia

Low referral completion of rapid diagnostic test-negative patients in community-based treatment of malaria in Sierra Leone

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

Community participation during two mass anti-malarial administrations in Cambodia: lessons from a joint workshop

The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar

Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

A review of the WHO malaria rapid diagnostic test product testing programme (2008–2018): performance, procurement and policy