logo
Science Portal
Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
About MSF Science Portal
About
Contact Us
Frequently Asked Questions (FAQs)
Privacy Policy
Terms of Use
Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 19 of 19 Items
Showing 1 - 19 of 19 Items
Sort By: Relevance
  • Newest to oldest
  • Oldest to newest
  • Relevance
Conference Material
|
Slide Presentation

Improving treatment of multidrug-resistant tuberculosis: Results of the endTB randomised clinical trial

Guglielmetti L, Khan U, Velasquez GE, Gouillou M, Lachenal N,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
|
Abstract

Improving treatment of multidrug-resistant tuberculosis: Results of the endTB randomised clinical trial

Guglielmetti L, Khan U, Velasquez GE, Gouillou M, Lachenal N,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
Tuberculosis (TB) is a major public health challenge encountered across many Médecins Sans Frontières (MSF) fields. Management of drug-resistant TB is an operational pri...
Technical Report
|
Study report

endTB clinical trial results

endTB Study Group
2023-11-15
2023-11-15
Conference Material
|
Slide Presentation

endTB Clinical Trial: Design, efficacy, safety & linezolid dose-reduction randomization results

endTB Study Group
2023-11-15 • The Union World Conference on Lung Health 2023
2023-11-15 • The Union World Conference on Lung Health 2023
Technical Report
|
Evidence Brief

High-quality evidence on new, all-oral, shortened MDR-TB regimens

endTB Study Group
2023-11-15
2023-11-15
Each year there are approximately 500,000 new cases of multidrug-resistant tuberculosis (MDR-TB) worldwide, but only a tiny fraction is successfully treated. The endTB trial, led by Méde...
Conference Material
|
Video

endTB trial results presentation

endTB Study Group
2023-10-06 • The Union World Conference on Lung Health 2023
2023-10-06 • The Union World Conference on Lung Health 2023
Research & Publication Guidance
|
Guidelines/How-Tos

Technical basis of the endTB observational study

endTB Study Group
2023-03-06
2023-03-06

endTB Observational Study had sites in 17 countries. In each country, sites enrolled patients on treatment with bedaquiline and delamanid according to National TB Program guidelines, ...

Journal Article
|
Research

Safety and effectiveness outcomes from a 14-country cohort of patients with multi-drug resistant tuberculosis treated concomitantly with bedaquiline, delamanid and other second-line drugs

Huerga H, Khan UT, Bastard M, Mitnick CD, Lachenal N,  et al.
2022-10-15 • Clinical Infectious Diseases
2022-10-15 • Clinical Infectious Diseases
BACKGROUND
Concomitant use of bedaquiline (Bdq) and delamanid (Dlm) for multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) has raised concerns about a potentially poor risk-ben...
Journal Article
|
Short Report

Culture conversion at six months in patients receiving delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis

Seung KJ, Khan PY, Franke MF, Ahmed SM, Aiylchiev S,  et al.
2019-11-02 • Clinical Infectious Diseases
2019-11-02 • Clinical Infectious Diseases
Delamanid should be effective against highly resistant strains of Mycobacterium tuberculosis, but uptake has been slow globally. In the endTB (expand new drug markets for TB) Observation...
Toolkit
|
Clinical

Pharmacovigilance - endTB study

endTB Study Group
2018-11-23
2018-11-23

Pharmacovigilance forms and other resources for staff on endTB sites.

Journal Article
|
Letter

High prevalence of hepatitis C infection among multidrug-resistant tuberculosis patients

Seung KJ, Franke MF, Hewison CCH, Huerga H, Khan UT,  et al.
2020-05-01 • Journal of Hepatology
2020-05-01 • Journal of Hepatology
Technical Report
|
Study report

Terms of reference: endTB medical committee

endTB Study Group
2017-05-13
2017-05-13

The endTB Medical Committee formulates recommendations for off-label and compassionate use of the new anti-TB drugs for M(X)DR-TB.

It provides advice to any MSF, PIH and IRD pro...

Journal Article
|
Research

Culture conversion in patients treated with bedaquiline and/or delamanid: A prospective multi-country study

Franke MF, Khan PY, Hewison CCH, Khan UT, Huerga H,  et al.
2020-07-24 • American Journal of Respiratory and Critical Care Medicine
2020-07-24 • American Journal of Respiratory and Critical Care Medicine
BACKGROUND
Bedaquiline and delamanid offer the possibility of more effective and less toxic multidrug-resistant tuberculosis (MDR-TB) treatment. With this treatment, however, some pa...
Research & Publication Guidance
|
Guidelines/How-Tos

endTB clinical and programmatic guide for patient management with new TB drugs

endTB Study Group
2016-11-25
2016-11-25

This guide is designed to give guidance to the endTB Project site on the use of new TB drugs bedaquiline and delamanid. It is intended to be a resource for physicians and other health...

Technical Report
|
Study report

Report of fatal and life-threatening adverse events during endTB post-marketing safety surveillance of new and repurposed TB drugs

endTB Study Group
2021-09-01
2021-09-01
Protocol
|
Research Protocol

The endTB COVID-19 response: Interim guidance for the endTB trial sites

endTB Study Group
2020-11-24
2020-11-24

This document is designed to give guidance to the endTB Project sites on the response to the COVID-19 outbreak. It is intended to be a resource for physicians and other health care pr...

Technical Report
|
Study report

endTB-Q Description Video

Guglielmetti L, endTB Study Group
2021-09-21
2021-09-21
Technical Report
|
Study report

WHO global consultation on transition towards new and better treatments for MDR-TB: endTB presentation

endTB Study Group
2019-04-16
2019-04-16

Researchers from endTB participated in the WHO Global Consortium to share updated results and the study’s implementation practices, in addition to evidence to support the transition, ...

Technical Report
|
Study report

endTB: Project presentation

endTB Study Group
2016-06-28
2016-06-28

This 20-page guide is designed to provide all endTB stakeholders with a detailed presentation of the project's four goals.