Search Results | MSF Science Portal

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Research

Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, et al.

2023-06-01 • Lancet Global Health

BACKGROUND
Sputum is the most widely used sample to diagnose active tuberculosis, but many people living with HIV are unable to produce sputum. Urine, in contrast, is readily availab...

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Research

Estill J, Egger M, Johnson LF, Gsponer T, Wandeler G, et al.

2013-02-28 • PLOS One

OBJECTIVES
Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral loa...

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Research

Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, et al.

2010-09-10 • AIDS

OBJECTIVE: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, ...

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Research

Cornell M, Technau KG, Fairall L, Wood R, Moultrie H, et al.

2009-09-01 • South African Medical Journal

OBJECTIVES: To introduce the combined South African cohorts of the International epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) collaboration as reflecting the South...

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Research

Lawn SD, Campbell L, Kaplan R, Boulle AM, Cornell M, et al.

2011-06-01 • Journal of Acquired Immune Deficiency Syndromes (1999)

We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per micro...

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Research

Hoffman CJ, Schomaker M, Fox MP, Mutevedzi, Giddy J, et al.

2013-01-22 • Journal of Acquired Immune Deficiency Syndromes (1999)

In many resource-limited settings monitoring of combination antiretroviral therapy (cART) is based on the current CD4 count, with limited access to HIV RNA tests or laboratory diagnostic...

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Research

Davies MA, Tsondai PR, Tiffin N, Eley B, Rabie H, et al.

2017-03-16 • Journal of the International AIDS Society

To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health ...

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Research

Fenner L, Brinkhof MW, Keiser O, Weigel R, Cornell M, et al.

2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)

BACKGROUND: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in chi...

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Research

Keiser O, Tweya H, Boulle AM, Braitstein P, Schechter M, et al.

2009-09-10 • AIDS

BACKGROUND
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring ...

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Schomaker M, Davies A, Malateste K, Renner L, Sawry S, et al.

2015-10-16 • Epidemiology

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Research

Egger M, Sidle J, Weigel R, Geng EH, Fox MP, et al.

2011-01-01 • PLOS Medicine

The World Health Organization estimates that in sub-Saharan Africa about 4 million HIV-infected patients had started antiretroviral therapy (ART) by the end of 2008. Loss of patients to ...

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Research

Johnson LF, Mossong J, Dorrington R, Schomaker M, Hoffman CJ, et al.

2013-04-09 • PLOS Medicine

Few estimates exist of the life expectancy of HIV-positive adults receiving antiretroviral treatment (ART) in low- and middle-income countries. We aimed to estimate the life expectancy o...

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Research

Koller M, Fatti G, Chi BH, Keiser O, Hoffman CJ, et al.

2015-07-07 • Journal of Acquired Immune Deficiency Syndromes (1999)

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Research

Wandeler G, Gsponer T, Mulenga L, Garone DB, Wood R, et al.

2013-09-01 • AIDS

OBJECTIVES
Zidovudine (ZDV) is recommended for first-line antiretroviral therapy (ART) in resource-limited settings. ZDV may, however, lead to anemia and impaired immunological respo...

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Research

Cornell M, Schomaker M, Garone DB, Giddy J, Hoffmann CJ, et al.

2012-09-04 • PLOS Medicine

Background: Increased mortality among men on antiretroviral therapy (ART) has been documented but remains poorly understood. We examined the magnitude of and risk factors for g...

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Research

Salazar-Vizcaya L, Keiser O, Technau KG, Davies MA, Haas AD, et al.

2014-10-23 • AIDS

OBJECTIVES
Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4⁺ to monitor ART. We assessed the benefit of replacing CD4⁺ by viral load monitoring....

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Research

Davies MA, Boulle AM, Technau KG, Eley B, Moultrie H, et al.

2012-09-01 • Tropical Medicine and International Health

OBJECTIVES
To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral ...

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Research

Davies MA, Moultrie H, Eley B, Rabie H, van Cutsem G, et al.

2011-03-01 • Journal of Acquired Immune Deficiency Syndromes (1999)

With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determ...

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Research

Keiser O, Orrell C, Egger M, Wood R, Brinkhof MW, et al.

2008-07-08 • PLOS Medicine

BACKGROUND: The provision of highly active antiretroviral therapy (HAART) in resource-limited settings follows a public health approach, which is characterised by a limited number of reg...

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Research

Cornell M, Johnson LF, Schomaker M, Tanser F, Maskew M, et al.

2015-08-03 • Lancet HIV

BACKGROUND
As access to antiretroviral therapy (ART) expands, increasing numbers of older patients will start treatment and need specialised long-term care. However, the effect of ag...

Science Portal

Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data

Monitoring of antiretroviral therapy and mortality in HIV programmes in Malawi, South Africa and Zambia: mathematical modelling study

Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007

Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the IeDEA Southern Africa collaboration

Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa

CD4 count slope and mortality in HIV-infected patients on antiretroviral therapy: multicohort analysis from South Africa

Where do HIV-infected adolescents go after transfer? - Tracking transition/transfer of HIV-infected adolescents using linkage of cohort data to a health information system platform

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring

Growth and mortality outcomes for different antiretroviral therapy initiation criteria in children aged 1-5 years: a causal modelling analysis

Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa

Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies

Risk charts to guide targeted HIV-1 viral load monitoring of ART: development and validation in patients from resource-limited settings

Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa

Gender differences in survival among adult patients starting antiretorivral therapy in South Africa: a multicentre cohort study

Viral load versus CD4⁺ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared

Age in antiretroviral therapy programmes in South Africa: a retrospective, multicentre, observational cohort study