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Research

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Schilling WHK, Mukaka M, Callery JJ, Llewelyn MJ, Cruz CV,  et al.
2024-09-12 • PLOS Medicine
2024-09-12 • PLOS Medicine

BACKGROUND

Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety an...

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Population pharmacokinetics of lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

Kloprogge F, Piola P, Dhorda M, Muwanga S, Turyakira E,  et al.
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
2013-11-13 • CPT: Pharmacometrics and Systems Pharmacology
Pregnancy alters the pharmacokinetic properties of many antimalarial compounds. The objective of this study was to evaluate the pharmacokinetic properties of lumefantrine in pregnant and...

Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar

Smithuis FM, Shahmanesh M, Kyaw MK, Savran O, Lwin S,  et al.
2004-11-01 • Tropical Medicine and International Health
2004-11-01 • Tropical Medicine and International Health
Multi-drug resistant falciparum malaria is widespread in Asia. In Thailand, Cambodia and Vietnam the national protocols have changed largely to artesunate combined treatment regimens but...

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A,  et al.
2010-11-08 • Lancet
2010-11-08 • Lancet
Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice...

The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar

Smithuis FM, Kyaw MK, van der Broek I, Katterman N, Rogers C,  et al.
2013-10-11 • Malaria Journal
2013-10-11 • Malaria Journal
BACKGROUND
Insecticide-treated bed nets (ITN) reduce malaria morbidity and mortality consistently in Africa, but their benefits have been less consistent in Asia. This study's object...

An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia

Leang R, Khu NH, Mukaka M, Debackere M, Tripura R,  et al.
2016-10-27 • BMC Medicine
2016-10-27 • BMC Medicine
BACKGROUND
In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to ...

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JH,  et al.
2007-04-01 • Journal of Infectious Diseases
2007-04-01 • Journal of Infectious Diseases
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudesce...

Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria

Mytton OT, Ashley EA, Peto L, Price RN, La Y,  et al.
2007-09-01 • American Journal of Tropical Medicine and Hygiene
2007-09-01 • American Journal of Tropical Medicine and Hygiene
Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical tri...

Responding to the evidence for the management of severe malaria

Ford NP, de Smet M, Kolappa K, White NJ
2011-06-20 • Tropical Medicine and International Health
2011-06-20 • Tropical Medicine and International Health

Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria

Taylor WRJ, Hoglund RM, Peerawaranun P, Nguyen TN, Hien TT,  et al.
2021-09-09 • Malaria Journal
2021-09-09 • Malaria Journal
BACKGROUND
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed tar...

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Kloprogge F, Workman L, Borrmann S, Tekete M, Lefevre G,  et al.
2018-06-12 • PLOS Medicine
2018-06-12 • PLOS Medicine
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine...

Geographical distribution of selected and putatively neutral SNPs in Southeast Asian malaria parasites

Anderson TJC, Nair SA, Sudimack D, Williams JT, Mayxay M,  et al.
2005-12-01 • Molecular Biology and Evolution
2005-12-01 • Molecular Biology and Evolution
Loci targeted by directional selection are expected to show elevated geographical population structure relative to neutral loci, and a flurry of recent papers have used this rationale to...

Plasmodium falciparum: sensitivity in vivo to chloroquine, pyrimethamine/sulfadoxine and mefloquine in western Myanmar

Smithuis FM, Monti F, Grundl M, Oo AZ, Kyaw TT,  et al.
2008-02-07 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-02-07 • Transactions of the Royal Society of Tropical Medicine and Hygiene
In Rakhine State, on the western border of Myanmar, the efficacy of chloroquine (CQ) and pyrimethamine/ sulfadoxine (PS), the current treatments for uncomplicated Plasmodium falciparum m...

Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial

Smithuis FM, Kyaw MK, Phe O, Win T, Aung PP,  et al.
2010-10-01 • Lancet Infectious Diseases
2010-10-01 • Lancet Infectious Diseases
BACKGROUND: Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whe...

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis

Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis FM,  et al.
2009-07-29 • PLOS One
2009-07-29 • PLOS One
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patien...

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...

Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development

Guerin PJ, Olliaro PL, Nosten F, Druilhe P, Laxminarayan R,  et al.
2002-09-01 • Lancet Infectious Diseases
2002-09-01 • Lancet Infectious Diseases
Rolling back malaria is possible. Tools are available but they are not used. Several countries deploy, as their national malaria control treatment policy, drugs that are no longer effect...

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant plasmodium falciparum distributions in Southeast Asia

Grist EP, Fleqq JA, Humphreys G, Mas IS, Anderson TJC,  et al.
2016-10-24 • International Journal of Health Geographics
2016-10-24 • International Journal of Health Geographics
BACKGROUND
Artemisinin-resistant Plasmodium falciparum malaria parasites are now present across much of mainland Southeast Asia, where ongoing surveys are measuring and mapping their...

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L,  et al.
2008-03-01 • Antimicrobial Agents and Chemotherapy
2008-03-01 • Antimicrobial Agents and Chemotherapy
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-pi...

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine and quinine in pregnant women with uncomplicated falciparum malaria in Uganda

Tarning J, Kloprogge F, Dhorda M, Jullien V, Nosten F,  et al.
2013-08-05 • Antimicrobial Agents and Chemotherapy
2013-08-05 • Antimicrobial Agents and Chemotherapy
ABSTRACTPregnancy alters the pharmacokinetic properties of many drugs used in the treatment of malaria, usually resulting in lower drug exposures. This i...