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Copyright © Médecins Sans Frontières
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Showing 1 - 19 of 19 Items
Showing 1 - 19 of 19 Items
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Journal Article
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Letter

Revised definitions of multidrug-resistant tuberculosis treatment outcomes: closer to the reality?

Bastard M, Bonnet MMB, du Cros PAK, Khamraev AK, Hayrapetyan A,  et al.
2015-02-01 • American Journal of Respiratory and Critical Care Medicine
2015-02-01 • American Journal of Respiratory and Critical Care Medicine
Journal Article
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Commentary

Introducing new and repurposed TB drugs: the endTB experience

Seung KJ, Khan UT, Varaine FFV, Ahmed SM, Bastard M,  et al.
2020-10-01 • International Journal of Tuberculosis and Lung Disease
2020-10-01 • International Journal of Tuberculosis and Lung Disease
In 2015, the initiative Expand New Drug Markets for TB (endTB) began, with the objective of reducing barriers to access to the new and repurposed TB drugs. Here we describe the major imp...
Journal Article
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Research

IPT during HIV treatment in Myanmar: high rates of coverage, completion and drug adherence

Ousley J, Soe KT, Kyaw NTT, Anicete R, Mon PE,  et al.
2018-03-21 • Public Health Action
2018-03-21 • Public Health Action
Setting: A southern Myanmar district providing isoniazid preventive therapy (IPT) in one of the last countries to formally recommend it as part of human immunodeficiency virus (HIV) care...
Journal Article
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Research

Outcomes of AIDS-associated Kaposi sarcoma in Mozambique after treatment with pegylated liposomal doxorubicin

Coldiron ME, Gutierrez Zamudio AG, Manuel R, Luciano G, Rusch B,  et al.
2021-01-07 • Infectious Agents and Cancer
2021-01-07 • Infectious Agents and Cancer
BACKGROUND
Kaposi’s sarcoma (KS) is a common HIV-associated malignancy frequently associated with poor outcomes. It is the most frequently diagnosed cancer in major cities of Mozambi...
Journal Article
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Research

Systematic, Point-of-Care Urine Lipoarabinomannan (Alere TB-LAM) Assay for Diagnosing Tuberculosis in Severely Immunocompromised HIV-Positive Ambulatory Patients

Huerga H, Cossa L, Manhiça I, Bastard M, Telnov A,  et al.
2020-03-05 • American Journal of Tropical Medicine and Hygiene
2020-03-05 • American Journal of Tropical Medicine and Hygiene
Point-of-care urine-lipoarabinomannan (LAM) Alere Determine TB-LAM assay has shown utility diagnosing tuberculosis (TB) in HIV-positive, severely immunocompromised, TB-symptomatic patien...
Journal Article
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Research

Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study.

Huerga H, Rucker SCM, Cossa L, Bastard M, Amoros I,  et al.
2019-04-30 • PLOS Medicine
2019-04-30 • PLOS Medicine
BACKGROUND:
Current guidelines recommend the use of the lateral flow urine lipoarabinomannan assay (LAM) in HIV-positive, ambulatory patients with signs and symptoms of tuberculosis...
Journal Article
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Short Report

Treatment outcomes of patients switching from an injectable drug to bedaquiline during short standardized MDR-TB treatment in Mozambique

Bastard M, Molfino L, Mutaquiha C, Galindo MA, Zindoga P,  et al.
2019-03-11 • Clinical Infectious Diseases
2019-03-11 • Clinical Infectious Diseases
Bedaquiline was recommended by WHO as the preferred option in treatment of MDR-TB patients with long regimen. However, no recommendation was given for the short MDR-TB regimen. Data from...
Journal Article
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Research

Outcomes of HIV-infected versus HIV-non-infected patients treated for drug-resistance tuberculosis: Multicenter cohort study

Bastard M, Sanchez-Padilla E, du Cros PAK, Khamraev AK, Parpieva N,  et al.
2018-03-08 • PLOS One
2018-03-08 • PLOS One
The emergence of resistance to anti-tuberculosis (DR-TB) drugs and the HIV epidemic represent a serious threat for reducing the global burden of TB. Although data on HIV-negative DR-TB t...
Conference Material
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Abstract

Diagnostic performance of lateral flow point-of-care HIV-Combo testing for detection of acute HIV infection in Eswatini

Kerschberger B, Ntshalintshali N, Maphalala G, Aung A, Mamba C,  et al.
2021-05-19 • MSF Scientific Days International 2021: Research
2021-05-19 • MSF Scientific Days International 2021: Research
INTRODUCTION
Acute HIV infection (AHI) is rarely diagnosed in resource-limited settings. Barriers to diagnosis include the high costs of viral load (VL)-based diagnostic testing algo...
Conference Material
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Abstract

Diagnosing and treating cases of acute HIV infection within a high HIV incidence setting: feasibility study, Eswatini

Aung A, Mamba C, Ntshalintshali N, Mpala Q, Mthethwa-Hleza S,  et al.
2020-05-26 • MSF Scientific Days International 2020: Research
2020-05-26 • MSF Scientific Days International 2020: Research
INTRODUCTION
Acute HIV infection (AHI) cannot be detected with routine point-of-care antibody tests and is rarely diagnosed in resource-limited settings. However, characteristics of ...
Conference Material
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Abstract

Video/Virtually Observed Therapy for patients with drug-resistant tuberculosis in Eswatini: a rapid response to COVID-19 lockdown measures

Aung A, Daka M, Tamrat A, Gwitima T, Chidhuro T,  et al.
2021-05-20 • MSF Scientific Days International 2021: Innovation
2021-05-20 • MSF Scientific Days International 2021: Innovation
WHAT CHALLENGE OR OPPORTUNITY DID YOU TRY TO ADDRESS? WERE EXISTING SOLUTIONS NOT AVAILABLE OR NOT GOOD ENOUGH?
The COVID-19 pandemic has prompted lockdown measures in many places, b...
Conference Material
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Poster

Establishment of a predictor risk score for the prioritization of patients for testing for acute HIV infection

Kerschberger B, Mpala Q, Aung A, Ntshalintshali N, Mamba C,  et al.
2021-05-18 • MSF Scientific Days International 2021: Research
2021-05-18 • MSF Scientific Days International 2021: Research
Journal Article
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Research

Successful expansion of community-based drug-resistant TB care in rural Eswatini - a retrospective cohort study

Kerschberger B, Telnov A, Yano N, Cox HS, Zabsonre I,  et al.
2019-10-01 • Tropical Medicine and International Health
2019-10-01 • Tropical Medicine and International Health
OBJECTIVES
Provision of drug-resistant tuberculosis (DR-TB) treatment is scarce in resource-limited settings. We assessed the feasibility of ambulatory DR-TB care for treatment expan...
Journal Article
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Research

Decreased risk of HIV-associated TB during antiretroviral therapy expansion in rural Eswatini from 2009 to 2016: a cohort and population-based analysis

Kerschberger B, Schomaker M, Telnov A, Vambe D, Kisyeri N,  et al.
2019-09-19 • Tropical Medicine and International Health
2019-09-19 • Tropical Medicine and International Health
OBJECTIVES
This paper assesses patient- and population-level trends in TB notifications during rapid expansion of antiretroviral therapy in Eswatini which has an extremely high incid...
Journal Article
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Research

Programmatic outcomes and impact of rapid public sector antiretroviral therapy expansion in adults prior to introduction of the WHO treat-all approach in rural Eswatini

Kerschberger B, Schomaker M, Ciglenecki I, Pasipamire M, Mabhena E,  et al.
2019-04-01 • Tropical Medicine and International Health
2019-04-01 • Tropical Medicine and International Health
To assess long-term antiretroviral therapy (ART) outcomes during rapid HIV programme expansion in the public sector of Eswatini (formerly Swaziland). This is a retrospectively establishe...
Journal Article
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Research

What is the best culture conversion prognostic marker for patients treated for multidrug-resistant tuberculosis?

Bastard M, Sanchez-Padilla E, Hayrapetyan A, Kimenye K, Khurkhumal S,  et al.
2019-10-01 • International Journal of Tuberculosis and Lung Disease
2019-10-01 • International Journal of Tuberculosis and Lung Disease
INTRODUCTION
Identification of good prognostic marker for tuberculosis (TB) treatment response is a necessary step on the path towards a surrogate marker to reduce TB trial duration....
Journal Article
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Research

Identification of patients who could benefit from bedaquiline or delamanid: a multisite MDR-TB cohort study

Bonnet MMB, Bastard M, du Cros PAK, Khamraev AK, Kimenye K,  et al.
2016-02-01 • International Journal of Tuberculosis and Lung Disease
2016-02-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
The World Health Organization recommends adding bedaquiline or delamanid to multidrug-resistant tuberculosis (MDR-TB) regimens for which four effective drugs are not avail...
Journal Article
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Research

Predicting, diagnosing, and treating acute and early HIV infection in a public sector facility in Eswatini

Kerschberger B, Aung A, Mpala Q, Ntshalintshali N, Mamba C,  et al.
2021-12-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2021-12-15 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
BACKGROUND
The lack of acute and early HIV infection (AEHI) diagnosis and care contributes to high HIV incidence in resource-limited settings. We aimed to assess the yield, predict a...
Conference Material
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Slide Presentation

Diagnostic performance of lateral flow point-of-care HIV-Combo testing for detection of acute HIV infection in Eswatini

Kerschberger B, Ntshalintshali N, Maphalala G, Aung A, Mamba C,  et al.
2021-05-19 • MSF Scientific Days International 2021: Research
2021-05-19 • MSF Scientific Days International 2021: Research