Showing 1 - 12 of 12 Items
Showing 1 - 12 of 12 Items
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Journal Article
|Research
2024-09-12 • PLOS Medicine
2024-09-12 • PLOS Medicine
BACKGROUND
Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety an...
Journal Article
|Research
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Journal Article
|Research
2016-10-27 • BMC Medicine
2016-10-27 • BMC Medicine
BACKGROUND
In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to ...
In 2012, the World Health Organization recommended the addition of single low-dose primaquine (SLDPQ, 0.25 mg base/kg body weight) to artemisinin combination therapies to ...
Journal Article
|Research
2021-09-09 • Malaria Journal
2021-09-09 • Malaria Journal
BACKGROUND
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed tar...
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed tar...
Journal Article
|Research
2005-04-23 • Lancet
2005-04-23 • Lancet
BACKGROUND: The six-dose regimen of artemether-lumefantrine is effective and is among combination therapies prioritised to replace antimalarials that no longer work in Africa. However, i...
Journal Article
|Research
2007-02-01 • Tropical Medicine and International Health
2007-02-01 • Tropical Medicine and International Health
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115)...
Journal Article
|Research
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Journal Article
|Research
2008-08-09 • Malaria Journal
2008-08-09 • Malaria Journal
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...
Journal Article
|Research
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerabi...
Journal Article
|Research
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...
Journal Article
|Research
2010-02-15 • Journal of Infectious Diseases
2010-02-15 • Journal of Infectious Diseases
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of mal...
Journal Article
|Research
2018-01-18 • BMC Medicine
2018-01-18 • BMC Medicine
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), wi...