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Showing 1 - 20 of 20 Items
Showing 1 - 20 of 20 Items
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Conference Material
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Slide Presentation

Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review

Wilson JM, Chowdhury F, Hassan S, Harriss E, Alves F,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Abstract

Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review

Wilson JM, Chowdhury F, Hassan S, Harriss E, Alves F,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
Visceral leishmaniasis (VL) is a neglected tropical disease prevalent in populations affected by poverty, war, and famine. Without effective treatment, death is the norm...
Journal Article
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Review

Blood transfusion in the care of patients with visceral leishmaniasis: a review of practices in therapeutic efficacy studies

Dahal P, Singh-Phulgenda S, Wilson JM, Cota G, Ritmeijer K,  et al.
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Blood transfusion remains an important aspect of patient management in visceral leishmaniasis (VL). However, transfusion triggers considered are poorly understood. This review summarises...
Journal Article
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Protocol

Haematological dynamics following treatment of visceral leishmaniasis: a protocol for systematic review and individual participant data (IPD) meta-analysis

Munir A, Dahal P, Kumar R, Singh-Phulgenda S, Siddiqui NA,  et al.
2023-12-14 • BMJ Open
2023-12-14 • BMJ Open
INTRODUCTION
Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30,000 new cases occurring annually. Despite anaemia being a common haematological manifestation of ...
Journal Article
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Protocol

Host, parasite and drug determinants of clinical outcomes following treatment of visceral leishmaniasis: a protocol for individual participant data meta-analysis

Kumar R, Dahal P, Singh-Phulgenda S, Siddiqui NA, Munir A,  et al.
2023-10-28 • BMJ Open
2023-10-28 • BMJ Open
INTRODUCTION
Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30 000 new cases occurring annually. There is an observed variation in the efficacy of the current f...
Journal Article
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Research

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A,  et al.
2010-11-08 • Lancet
2010-11-08 • Lancet
Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice...
Journal Article
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Research

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q,  et al.
2020-02-25 • BMC Medicine
2020-02-25 • BMC Medicine
BACKGROUND
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquin...
Journal Article
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Research

The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar

Smithuis FM, Kyaw MK, van der Broek I, Katterman N, Rogers C,  et al.
2013-10-11 • Malaria Journal
2013-10-11 • Malaria Journal
BACKGROUND
Insecticide-treated bed nets (ITN) reduce malaria morbidity and mortality consistently in Africa, but their benefits have been less consistent in Asia. This study's object...
Journal Article
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Research

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C,  et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Journal Article
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Review

Complex interactions between malaria and malnutrition: a systematic literature review

Das D, Grais RF, Okiro EA, Stepniewska K, Mansoor R,  et al.
2018-10-29 • BMC Medicine
2018-10-29 • BMC Medicine
Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of ...
Journal Article
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Research

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Kloprogge F, Workman L, Borrmann S, Tekete M, Lefevre G,  et al.
2018-06-12 • PLOS Medicine
2018-06-12 • PLOS Medicine
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Protocol
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Research Protocol

A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F,  et al.
2015-06-12 • BMC Infectious Diseases
2015-06-12 • BMC Infectious Diseases
Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severel...
Journal Article
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Research

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis

Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis FM,  et al.
2009-07-29 • PLOS One
2009-07-29 • PLOS One
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patien...
Journal Article
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Research

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...
Journal Article
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Research

Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L,  et al.
2008-03-01 • Antimicrobial Agents and Chemotherapy
2008-03-01 • Antimicrobial Agents and Chemotherapy
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-pi...
Journal Article
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Research

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Lee SJ, Stepniewska K, Anstey NM, Ashley EA, Barnes KI,  et al.
2008-08-01 • Malaria Journal
2008-08-01 • Malaria Journal
BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For compari...
Journal Article
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Research

In vivo parasitological measures of artemisinin susceptibility

Stepniewska K, Ashley EA, Lee SJ, Anstey NM, Barnes KI,  et al.
2010-02-15 • Journal of Infectious Diseases
2010-02-15 • Journal of Infectious Diseases
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of mal...
Journal Article
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Research

Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison

Smithuis FM, Kyaw MK, Phe O, Aye KZ, Htet L,  et al.
2006-06-24 • Lancet
2006-06-24 • Lancet
BACKGROUND: Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast ...
Journal Article
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Research

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Hossain MS, Commons RJ, Douglas NM, Thriemer KL, Alemayehu BH,  et al.
2020-11-19 • PLOS Medicine
2020-11-19 • PLOS Medicine
Background: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using a...