Wilson JM, Chowdhury F, Hassan S, Harriss E, Alves F, et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION Visceral leishmaniasis (VL) is a neglected tropical disease prevalent in populations affected by poverty, war, and famine. Without effective treatment, death is the norm...
Dahal P, Singh-Phulgenda S, Wilson JM, Cota G, Ritmeijer K, et al.
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Blood transfusion remains an important aspect of patient management in visceral leishmaniasis (VL). However, transfusion triggers considered are poorly understood. This review summarises...
Munir A, Dahal P, Kumar R, Singh-Phulgenda S, Siddiqui NA, et al.
2023-12-14 • BMJ Open
2023-12-14 • BMJ Open
INTRODUCTION Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30,000 new cases occurring annually. Despite anaemia being a common haematological manifestation of ...
Kumar R, Dahal P, Singh-Phulgenda S, Siddiqui NA, Munir A, et al.
2023-10-28 • BMJ Open
2023-10-28 • BMJ Open
INTRODUCTION Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30 000 new cases occurring annually. There is an observed variation in the efficacy of the current f...
Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q, et al.
2020-02-25 • BMC Medicine
2020-02-25 • BMC Medicine
BACKGROUND The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquin...
Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, et al.
2010-11-08 • Lancet
2010-11-08 • Lancet
Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice...
Smithuis FM, Kyaw MK, van der Broek I, Katterman N, Rogers C, et al.
2013-10-11 • Malaria Journal
2013-10-11 • Malaria Journal
BACKGROUND Insecticide-treated bed nets (ITN) reduce malaria morbidity and mortality consistently in Africa, but their benefits have been less consistent in Asia. This study's object...
Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Das D, Grais RF, Okiro EA, Stepniewska K, Mansoor R, et al.
2018-10-29 • BMC Medicine
2018-10-29 • BMC Medicine
Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of ...
Kloprogge F, Workman L, Borrmann S, Tekete M, Lefevre G, et al.
2018-06-12 • PLOS Medicine
2018-06-12 • PLOS Medicine
The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine...
WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J, et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, et al.
2015-06-12 • BMC Infectious Diseases
2015-06-12 • BMC Infectious Diseases
Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severel...
Zwang J, Ashley EA, Karema C, D'Alessandro U, Smithuis FM, et al.
2009-07-29 • PLOS One
2009-07-29 • PLOS One
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patien...
Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM, et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...
Tarning J, Ashley EA, Lindegardh N, Stepniewska K, Phaiphun L, et al.
2008-03-01 • Antimicrobial Agents and Chemotherapy
2008-03-01 • Antimicrobial Agents and Chemotherapy
The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-pi...
Lee SJ, Stepniewska K, Anstey NM, Ashley EA, Barnes KI, et al.
2008-08-01 • Malaria Journal
2008-08-01 • Malaria Journal
BACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For compari...
Stepniewska K, Ashley EA, Lee SJ, Anstey NM, Barnes KI, et al.
2010-02-15 • Journal of Infectious Diseases
2010-02-15 • Journal of Infectious Diseases
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of mal...
Hossain MS, Commons RJ, Douglas NM, Thriemer KL, Alemayehu BH, et al.
2020-11-19 • PLOS Medicine
2020-11-19 • PLOS Medicine
Background: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using a...
Smithuis FM, Kyaw MK, Phe O, Aye KZ, Htet L, et al.
2006-06-24 • Lancet
2006-06-24 • Lancet
BACKGROUND: Artemisinin-based combinations are judged the best treatments for multidrug-resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in southeast ...
