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Journal Article
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Research

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

Sissoko D, Laouenan C, Folkesson E, M’Lebing A, Beavogui A,  et al.
2016-03-01 • PLOS Medicine
2016-03-01 • PLOS Medicine
Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health ...
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Commentary

Favipiravir Pharmacokinetics in Ebola-Infected Patients of the JIKI Trial Reveals Concentrations Lower Than Targeted

Nguyen TN, Guedj J, Anglaret X, Laouenan C, Madelain V,  et al.
2017-02-23 • PLOS Neglected Tropical Diseases
2017-02-23 • PLOS Neglected Tropical Diseases
In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for thi...

Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola Virus Disease and Is consistent with bacterial translocation across the gut

Carroll MW, Haldenby S, Rickett NY, Palyi B, Garcia-Dorival I,  et al.
2017-08-30 • mSphere
2017-08-30 • mSphere
In this study, samples from the 2013-2016 West African Ebola virus outbreak from patients in Guinea with Ebola virus disease (EVD) were analyzed to discover and classify what other patho...

Transcriptomic Signatures Differentiate Survival from Fatal Outcomes in Humans Infected with Ebola Virus

Liu X, Speranza E, Munoz-Fontela C, Haldenby S, Rickett NY,  et al.
2017-01-19 • Genome Biology
2017-01-19 • Genome Biology
In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimisi...

Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: a case study in Guinea, West Africa

Carazo Perez S, Folkesson E, Anglaret X, Beavogui A, Berbain E,  et al.
2017-06-22 • PLOS Neglected Tropical Diseases
2017-06-22 • PLOS Neglected Tropical Diseases
During the large Ebola outbreak that affected West Africa in 2014 and 2015, studies were launched to evaluate potential treatments for the disease. A clinical trial to evaluate the effec...