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Copyright © Médecins Sans Frontières
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Showing 1 - 4 of 4 Items
Showing 1 - 4 of 4 Items
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Journal Article
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Research

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Journal Article
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Research

A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms

Ménard D, Khim N, Beghain J, Adegnika AA, Alam MS,  et al.
2016-06-23 • New England Journal of Medicine
2016-06-23 • New England Journal of Medicine
Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Journal Article
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Research

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

Taylor WRJ, Naw HK, Maitland K, Williams TN, Kapulu M,  et al.
2018-01-18 • BMC Medicine
2018-01-18 • BMC Medicine
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), wi...