Protocol > Research Protocol
Kosack CS, Halton J, Greig J, Shanks L, Spijker S
1 July 2018
PRIMARY OBJECTIVE OF STUDY
• To demonstrate the extent of change in patient management through the availability of digital X-ray with teleradiology consultation.
SECONDARY OBJECTIVES OF STUDY
• To demonstrate the extent of change in patient diagnosis through the availability of digital X-ray with teleradiology consultation.
• To demonstrate the extent of change in patient diagnosis and management in the subgroup of patients with chest pathologies through the availability of digital X-ray with teleradiology consultation.
• To estimate if the extent of change in diagnosis and management is different in patients < 5 years of age versus ≥5 years of age.
• To demonstrate the extent of change in patient management through the availability of digital X-ray with teleradiology consultation.
SECONDARY OBJECTIVES OF STUDY
• To demonstrate the extent of change in patient diagnosis through the availability of digital X-ray with teleradiology consultation.
• To demonstrate the extent of change in patient diagnosis and management in the subgroup of patients with chest pathologies through the availability of digital X-ray with teleradiology consultation.
• To estimate if the extent of change in diagnosis and management is different in patients < 5 years of age versus ≥5 years of age.
Journal Article > ResearchFull Text
Confl Health. 17 June 2010; Volume 4; 12.; DOI:10.1186/1752-1505-4-12
O'Brien DP, Venis S, Greig J, Shanks L, Ellman T, et al.
Confl Health. 17 June 2010; Volume 4; 12.; DOI:10.1186/1752-1505-4-12
INTRODUCTION
Many countries ravaged by conflict have substantial morbidity and mortality attributed to HIV/AIDS yet HIV treatment is uncommonly available. Universal access to HIV care cannot be achieved unless the needs of populations in conflict-affected areas are addressed.
METHODS
From 2003 Médecins Sans Frontières introduced HIV care, including antiretroviral therapy, into 24 programmes in conflict or post-conflict settings, mainly in sub-Saharan Africa. HIV care and treatment activities were usually integrated within other medical activities. Project data collected in the Fuchia software system were analysed and outcomes compared with ART-LINC data. Programme reports and other relevant documents and interviews with local and headquarters staff were used to develop lessons learned.
RESULTS
In the 22 programmes where ART was initiated, more than 10,500 people were diagnosed with HIV and received medical care, and 4555 commenced antiretroviral therapy, including 348 children. Complete data were available for adults in 20 programmes (n = 4145). At analysis, 2645 (64%) remained on ART, 422 (10%) had died, 466 (11%) lost to follow-up, 417 (10%) transferred to another programme, and 195 (5%) had an unclear outcome. Median 12-month mortality and loss to follow-up were 9% and 11% respectively, and median 6-month CD4 gain was 129 cells/mm3. Patient outcomes on treatment were comparable to those in stable resource-limited settings, and individuals and communities obtained significant benefits from access to HIV treatment. Programme disruption through instability was uncommon with only one program experiencing interruption to services, and programs were adapted to allow for disruption and population movements. Integration of HIV activities strengthened other health activities contributing to health benefits for all victims of conflict and increasing the potential sustainability for implemented activities.
CONCLUSIONS
With commitment, simplified treatment and monitoring, and adaptations for potential instability, HIV treatment can be feasibly and effectively provided in conflict or post-conflict settings.
Many countries ravaged by conflict have substantial morbidity and mortality attributed to HIV/AIDS yet HIV treatment is uncommonly available. Universal access to HIV care cannot be achieved unless the needs of populations in conflict-affected areas are addressed.
METHODS
From 2003 Médecins Sans Frontières introduced HIV care, including antiretroviral therapy, into 24 programmes in conflict or post-conflict settings, mainly in sub-Saharan Africa. HIV care and treatment activities were usually integrated within other medical activities. Project data collected in the Fuchia software system were analysed and outcomes compared with ART-LINC data. Programme reports and other relevant documents and interviews with local and headquarters staff were used to develop lessons learned.
RESULTS
In the 22 programmes where ART was initiated, more than 10,500 people were diagnosed with HIV and received medical care, and 4555 commenced antiretroviral therapy, including 348 children. Complete data were available for adults in 20 programmes (n = 4145). At analysis, 2645 (64%) remained on ART, 422 (10%) had died, 466 (11%) lost to follow-up, 417 (10%) transferred to another programme, and 195 (5%) had an unclear outcome. Median 12-month mortality and loss to follow-up were 9% and 11% respectively, and median 6-month CD4 gain was 129 cells/mm3. Patient outcomes on treatment were comparable to those in stable resource-limited settings, and individuals and communities obtained significant benefits from access to HIV treatment. Programme disruption through instability was uncommon with only one program experiencing interruption to services, and programs were adapted to allow for disruption and population movements. Integration of HIV activities strengthened other health activities contributing to health benefits for all victims of conflict and increasing the potential sustainability for implemented activities.
CONCLUSIONS
With commitment, simplified treatment and monitoring, and adaptations for potential instability, HIV treatment can be feasibly and effectively provided in conflict or post-conflict settings.
Research & Publication Guidance > Guidelines/How-Tos
McConnell R, Roll S, van der Kam S, Shanks L, Venis S, et al.
1 February 2012
Journal Article > CommentaryFull Text
J Int AIDS Soc. 19 July 2017; Volume 20 (Issue 1); DOI:10.7448/IAS.20.1.22098
Kosack CS, Page AL, Beelaert G, Benson TT, Savane A, et al.
J Int AIDS Soc. 19 July 2017; Volume 20 (Issue 1); DOI:10.7448/IAS.20.1.22098
Journal Article > ResearchFull Text
J Int AIDS Soc. 22 March 2017 (Issue 1)
Kosack CS, Page AL, Beelaert G, Benson TT, Savane A, et al.
J Int AIDS Soc. 22 March 2017 (Issue 1)
Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant performance issues. Despite widespread use of RDTs for HIV diagnosis in resource-constrained settings, there has been no systematic, head-to-head evaluation of their accuracy with specimens from diverse settings across sub-Saharan Africa. We conducted a standardized, centralized evaluation of eight HIV RDTs and two simple confirmatory assays at a WHO collaborating centre for evaluation of HIV diagnostics using specimens from six sites in five sub-Saharan African countries.
Journal Article > ReviewAbstract
Expert Rev Anti Infect Ther. 1 January 2014; Volume 12 (Issue 1); DOI:10.1586/14787210.2014.866516
Klarkowiski D, O'Brien DP, Shanks L, Singh KR
Expert Rev Anti Infect Ther. 1 January 2014; Volume 12 (Issue 1); DOI:10.1586/14787210.2014.866516
HIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.
Journal Article > ResearchFull Text
PLOS One. 16 April 2014; Volume 9 (Issue 4); DOI:10.1371/journal.pone.0093716
Greig J, Thurtle N, Cooney L, Ariti C, Ahmed AO, et al.
PLOS One. 16 April 2014; Volume 9 (Issue 4); DOI:10.1371/journal.pone.0093716
In 2010, Médecins Sans Frontières (MSF) investigated reports of high mortality in young children in Zamfara State, Nigeria, leading to confirmation of villages with widespread acute severe lead poisoning. In a retrospective analysis, we aimed to determine venous blood lead level (VBLL) thresholds and risk factors for encephalopathy using MSF programmatic data from the first year of the outbreak response.
Journal Article > ResearchFull Text
BMC Medical Ethics. 2 June 2015; Volume 16 (Issue 1); DOI:10.1186/s12910-015-0032-x
Shanks L, Moroni C, Rivera IC, Price DJ, Clementine SB, et al.
BMC Medical Ethics. 2 June 2015; Volume 16 (Issue 1); DOI:10.1186/s12910-015-0032-x
Community consultation is increasingly recommended, and in some cases, required by ethical review boards for research that involves higher levels of ethical risk such as international research and research with vulnerable populations. In designing a randomised control trial of a mental health intervention using a wait list control, we consulted the community where the research would be undertaken prior to finalising the study protocol. The study sites were two conflict-affected locations: Grozny in the Chechen Republic and Kitchanga in eastern Democratic Republic of Congo.
Journal Article > ResearchFull Text
PLOS One. 25 April 2012; Volume 7 (Issue 4); DOI:10.1371/journal.pone.0035006
van der Kam S, Swarthout TD, Niragira O, Froud A, Sompwe EM, et al.
PLOS One. 25 April 2012; Volume 7 (Issue 4); DOI:10.1371/journal.pone.0035006
Catch-up growth after an infection is essential for children to maintain good nutritional status. To prevent malnutrition, WHO recommends that children are given one additional healthy meal per day during the 2 weeks after onset of illness. We investigated to what extent ready-to-use therapeutic food (RUTF) promotes catch-up growth in children after an acute, uncomplicated episode of Plasmodium falciparum malaria.
Journal Article > ResearchFull Text
PLOS One. 10 July 2015; Volume 10 (Issue 7); e0132422.; DOI:10.1371/journal.pone.0132422
Shanks L, Ritmeijer KKD, Piriou E, Siddiqui MR, Kliescikova J, et al.
PLOS One. 10 July 2015; Volume 10 (Issue 7); e0132422.; DOI:10.1371/journal.pone.0132422
Co-infection with HIV and visceral leishmaniasis is an important consideration in treatment of either disease in endemic areas. Diagnosis of HIV in resource-limited settings relies on rapid diagnostic tests used together in an algorithm. A limitation of the HIV diagnostic algorithm is that it is vulnerable to falsely positive reactions due to cross reactivity. It has been postulated that visceral leishmaniasis (VL) infection can increase this risk of false positive HIV results. This cross sectional study compared the risk of false positive HIV results in VL patients with non-VL individuals.