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Showing 1 - 20 of 31 Items
Showing 1 - 20 of 31 Items
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Journal Article
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Research

Provision of antiretroviral treatment in conflict settings: the experience of Médecins Sans Frontières

O'Brien DP, Venis S, Greig J, Shanks L, Ellman T,  et al.
2010-06-17 • Conflict and Health
2010-06-17 • Conflict and Health
INTRODUCTION
Many countries ravaged by conflict have substantial morbidity and mortality attributed to HIV/AIDS yet HIV treatment is uncommonly available. Universal access to HIV car...
Protocol
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Research Protocol

The impact of digital X-ray with teleradiology on case management in Mweso, Democratic Republic of Congo

Kosack CS, Halton J, Greig J, Shanks L, Spijker S
2018-07-01
2018-07-01
PRIMARY OBJECTIVE OF STUDY
• To demonstrate the extent of change in patient management through the availability of digital X-ray with teleradiology consultation.

SECOND...
Research & Publication Guidance
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Guidelines/How-Tos

Randomised controlled trials: how to do them in MSF

McConnell R, Roll S, van der Kam S, Shanks L, Venis S,  et al.
2012-02-01
2012-02-01
Journal Article
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Research

Towards More Accurate HIV Testing in Sub-Saharan Africa: a Multi-Site Evaluation of HIV RDTs and Risk Factors For False Positives

Kosack CS, Page AL, Beelaert G, Benson TT, Savane A,  et al.
2017-03-22 • Journal of the International AIDS Society
2017-03-22 • Journal of the International AIDS Society
Although individual HIV rapid diagnostic tests (RDTs) show good performance in evaluations conducted by WHO, reports from several African countries highlight potentially significant perf...
Journal Article
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Research

Association of blood lead level with neurological features in 972 children affected by an acute severe lead poisoning outbreak in zamfara state, northern Nigeria

Greig J, Thurtle N, Cooney L, Ariti C, Ahmed AO,  et al.
2014-04-16 • PLOS One
2014-04-16 • PLOS One
In 2010, Médecins Sans Frontières (MSF) investigated reports of high mortality in young children in Zamfara State, Nigeria, leading to confirmation of villages with widespread acute seve...
Journal Article
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Commentary

Response to Comment on "Alert, but not Alarmed" - A Comment on "Towards More Accurate HIV Testing in Sub-Saharan Africa: A Multi-Site Evaluation of HIV RDTs and Risk Factors for False Positives (Kosack et al. 2017)"

Kosack CS, Page AL, Beelaert G, Benson TT, Savane A,  et al.
2017-07-19 • Journal of the International AIDS Society
2017-07-19 • Journal of the International AIDS Society
Journal Article
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Review

Causes of false-positive HIV rapid diagnostic test results

Klarkowiski D, O'Brien DP, Shanks L, Singh KR
2014-01-01 • Expert Review of Anti-Infective Therapy
2014-01-01 • Expert Review of Anti-Infective Therapy
HIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same ...
Journal Article
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Research

"Losing the tombola": a case study describing the use of community consultation in designing the study protocol for a randomised controlled trial of a mental health intervention in two conflict-affected regions

Shanks L, Moroni C, Rivera IC, Price DJ, Clementine SB,  et al.
2015-06-02 • BMC Medical Ethics
2015-06-02 • BMC Medical Ethics
Community consultation is increasingly recommended, and in some cases, required by ethical review boards for research that involves higher levels of ethical risk such as international re...
Journal Article
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Research

Monitoring and evaluating psychosocial intervention outcomes in humanitarian aid

de Jong K, Ariti C, van der Kam S, Mooren TTM, Shanks L,  et al.
2016-06-17 • PLOS One
2016-06-17 • PLOS One
Existing tools for evaluating psychosocial interventions (un-validated self-reporting questionnaires) are not ideal for use in non-Western conflict settings. We implement a generic metho...
Journal Article
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Research

Diagnostic accuracy evaluation of the ImmunoFlow HCV rapid immunochromatographic test for the detection of hepatitis C antibodies

Kosack CS, Nick S, Shanks L
2014-04-13 • Journal of Virological Methods
2014-04-13 • Journal of Virological Methods
2% of the world's population lives with a hepatitis C virus (HCV) infection with highest rates in developing countries. The most common mode of transmission takes place via unsafe blood ...
Journal Article
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Research

Ready-to-use therapeutic food for Catch-up Growth in children after an episode of Plasmodium Falciparum Malaria: an open randomised controlled trial

van der Kam S, Swarthout TD, Niragira O, Froud A, Sompwe EM,  et al.
2012-04-25 • PLOS One
2012-04-25 • PLOS One
Catch-up growth after an infection is essential for children to maintain good nutritional status. To prevent malnutrition, WHO recommends that children are given one additional healthy m...
Journal Article
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Research

Accounting for false positive HIV tests: Is visceral leishmaniasis responsible?

Shanks L, Ritmeijer KKD, Piriou E, Siddiqui MR, Kliescikova J,  et al.
2015-07-10 • PLOS One
2015-07-10 • PLOS One
Co-infection with HIV and visceral leishmaniasis is an important consideration in treatment of either disease in endemic areas. Diagnosis of HIV in resource-limited settings relies on ra...
Protocol
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Research Protocol

Outcome Evaluation Study of MSF Mental Health Programs in Grozny, Chechnya Republic

Shanks L, Pintaldi G
2013-09-01
2013-09-01
Journal Article
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Research

Variation in specificity of HIV rapid diagnostic tests over place and time: an analysis of discordancy data using a Bayesian approach

Klarkowiski D, Glass K, O'Brien DP, Lokuge K, Piriou E,  et al.
2013-11-25 • PLOS One
2013-11-25 • PLOS One
BACKGROUND
Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or ...
Journal Article
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Research

False positive HIV diagnoses in resource limited settings: operational lessons learned for HIV programmes

Shanks L, Klarkowiski D, O'Brien DP
2013-03-20 • PLOS One
2013-03-20 • PLOS One
Access to HIV diagnosis is life-saving; however the use of rapid diagnostic tests in combination is vulnerable to wrongly diagnosing HIV infection when both screening tests give a false ...
Journal Article
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Research

Designing HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in sub-Saharan Africa

Kosack CS, Shanks L, Beelaert G, Benson TT, Savane A,  et al.
2017-07-26 • Journal of Clinical Microbiology
2017-07-26 • Journal of Clinical Microbiology
Our objective was to evaluate the performance of HIV testing algorithms based on WHO recommendations, using data from specimens collected at six HIV testing and counselling sites in sub-...
Journal Article
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Research

Similar mortality and reduced loss to follow-up in integrated compared with vertical programs providing antiretroviral treatment in sub-saharan Africa

Greig J, O'Brien DP, Ford NP, Spelman T, Sabapathy K,  et al.
2011-11-30 • Journal of Acquired Immune Deficiency Syndromes (1999)
2011-11-30 • Journal of Acquired Immune Deficiency Syndromes (1999)
Vertical HIV programs have achieved good results but may not be feasible or appropriate in many resource-limited settings. Médecins sans Frontières has treated HIV in vertical programs s...
Protocol
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Research Protocol

Multi-site evaluation of HIV testing algorithms

Kosack CS, Page AL, Shanks L, Chaillet P, Beelaert G,  et al.
2018-07-01
2018-07-01
Objectives
3.1 Primary objective
 To evaluate the overall and site-specific performance of the diagnostic algorithm performed at 6
MSF African program sites (i.e. using R...
Journal Article
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Research

Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis

Ford NP, Hargreaves S, Shanks L
2012-08-30 • PLOS One
2012-08-30 • PLOS One
Sepsis is one of the leading causes of childhood mortality, yet controversy surrounds the current treatment approach. We conducted a systematic review to assess the evidence base for flu...
Journal Article
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Research

Effect of short-term supplementation with ready-to-use therapeutic food or micronutrients for children after Iilness for prevention of malnutrition: a randomised controlled trial in Uganda

van der Kam S, Salse-Ubach N, Roll S, Swarthout TD, Gayton-Toyoshima S,  et al.
2016-02-09 • PLOS Medicine
2016-02-09 • PLOS Medicine
Globally, Médecins Sans Frontières (MSF) treats more than 300,000 severely malnourished children annually. Malnutrition is not only caused by lack of food but also by illnesses and by po...