Search Results | MSF Science Portal

Journal Article

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Commentary

Vonasek BJ, Marcy O, Armour J, Casenghi M, Cazes C, et al.

2025-03-23 • Lancet Child and Adolescent Health

Each day more than 500 children younger than 15 years die from tuberculosis. Considerable progress has been...

Journal Article

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Research

Garcia-Prats AJ, Garcia-Cremades M, Cox V, Kredo T, Dunbar R, et al.

2025-02-01 • Lancet Child and Adolescent Health

BACKGROUND

There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially ...

Journal Article

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Research

Melingui BF, Leroy-Terquem E, Palmer M, Taguebue JV, Wachinou AP, et al.

2024-02-01 • IJTLD OPEN

BACKGROUND
Chest X-ray (CXR) interpretation is challenging for the diagnosis of paediatric TB. We assessed the performance of a three half-day CXR training module for healthcare work...

Journal Article

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Research

du Cros PAK, Greig J, Cross GB, Cousins C, Berry C, et al.

2023-12-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
The value, speed of completion and robustness of the evidence generated by TB treatment trials could be improved by implementing standards for best practice.

METH...

Journal Article

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Research

Chiang SS, Graham SM, Schaaf HS, Marais BJ, Sant’Anna CC, et al.

2023-08-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
These clinical standards aim to provide guidance for diagnosis, treatment, and management of drug-susceptible TB in children and adolescents.

METHODS
Fifty-tw...

Journal Article

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Research

Gunasekera KS, Marcy O, Muñoz J, Lopez-Varela E, Sekadde MP, et al.

2023-03-13 • Lancet Child and Adolescent Health

BACKGROUND
Many children with pulmonary tuberculosis remain undiagnosed and untreated with related high morbidity and mortality. Recent advances in childhood tuberculosis algorithm d...

Journal Article

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Commentary

Chiang SS, Waterous PM, Atieno VF, Bernays S, Bondarenko Y, et al.

2023-03-01 • Journal of Adolescent Health

Journal Article

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Research

Marcy O, Wobudeya E, Font H, Vessière A, Chabala C, et al.

2023-03-01 • Lancet Infectious Diseases

BACKGROUND
Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...

Journal Article

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Research

Swaminathan A, du Cros PAK, Seddon JA, Mirgayosieva S, Asladdin R, et al.

2017-06-12 • BMC Infectious Diseases

Extensively drug-resistant (XDR) tuberculosis (TB) and multidrug resistant (MDR)-TB with additional resistance to injectable agents or fluoroquinolones are challenging to treat due to la...

Journal Article

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Commentary

Nash M, Perrin C, Seddon JA, Furin J, Hauser J, et al.

2020-12-01 • Lancet Child and Adolescent Health

Journal Article

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Commentary

Cox V, McKenna L, Acquah R, Reuter A, Wasserman S, et al.

2020-11-01 • International Journal of Tuberculosis and Lung Disease

Rapid diagnostics, newer drugs, repurposed medications, and shorter regimens have radically altered the landscape for treating rifampicin-resistant TB (RR-TB) and multidrug-resistant TB ...

Journal Article

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Research

Reuter A, Tisile P, von Delft D, Cox HS, Cox V, et al.

2017-11-01 • International Journal of Tuberculosis and Lung Disease

For decades, second-line injectable agents (IAs) have been the cornerstone of treatment for multidrug-resistant tuberculosis (MDR-TB). Although evidence on the efficacy of IAs is limited...

Journal Article

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Commentary

Loveday M, Reuter A, Furin J, Seddon JA, Cox HS

2019-03-22 • Lancet Infectious Diseases

Final results of the STREAM trial were presented at the 2018, 49th Union World Conference on Lung Health, held in The Hague, The Netherlands. STREAM is a randomised controlled trial comp...

Journal Article

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Letter

Achar J, Berry C, Herboczek K, Parpieva N, Tillashaykhov M, et al.

2015-09-09 • Emerging Infectious Diseases

Journal Article

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Research

du Cros PAK, Swaminathan A, Bobokhojaev O, Sharifovna ZD, Martin C, et al.

2015-06-21 • Public Health Action

Guidelines for children with drug-resistant tuberculosis (DR-TB) tend to focus on individual patient care; there is little guidance for national tuberculosis programmes (NTPs) on how to...

Journal Article

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Review

Harausz EP, Garcia-Prats AJ, Seddon JA, Schaaf HS, Hesseling AC, et al.

2016-11-17 • American Journal of Respiratory and Critical Care Medicine

It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and r...

Journal Article

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Research

Ettehad D, Schaaf HS, Seddon JA, Cooke GS, Ford NP

2012-02-27 • Lancet Infectious Diseases

Journal Article

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Research

Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, et al.

2018-07-11 • PLOS Medicine

An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB; Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known about the optima...

Journal Article

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Research

Swaminathan A, du Cros PAK, Seddon JA, Quinnell S, Bobokhojaev O, et al.

2016-04-01 • International Journal of Tuberculosis and Lung Disease

BACKGROUND
Management of extensively drug-resistant tuberculosis (XDR-TB) and pre-XDR-TB is challenging, as effective drugs are lacking. Group 5 anti-tuberculosis drugs have an uncle...

Journal Article

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Letter

Cox HS, Reuter A, Furin J, Seddon JA

2017-09-02 • Lancet

Science Portal

Leveraging nutritional rehabilitation and tuberculosis programmes to tackle tuberculosis and severe acute malnutrition in children

Characteristics of children and adolescents with multidrug-resistant and rifampicin-resistant tuberculosis and their association with treatment outcomes: a systematic review and individual participant data meta-analysis

Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB

Standards for clinical trials for treating TB

Clinical standards for drug-susceptible TB in children and adolescents

Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Caring for adolescents and young adults with tuberculosis or at risk of tuberculosis: Consensus statement from an international expert panel

Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Peripheral Neuropathy in a Diabetic Child Treated with Linezolid for Multidrug-Resistant Tuberculosis: A Case Report and Review of the Literature

Access to paediatric formulations for the treatment of childhood tuberculosis

Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB

The devil we know: is the use of injectable agents for the treatment of MDR-TB justified?

The STREAM trial: missed opportunities and lessons for future clinical trials

Multidrug-Resistant Tuberculosis in Child Successfully Treated with 9-Month Drug Regimen

Challenges and solutions to implementing drug-resistant tuberculosis programmes for children in Central Asia

New and repurposed drugs for pediatric multidrug-resistant tuberculosis. Practice-based recommendations

Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis

Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis

Treating children for drug-resistant tuberculosis in Tajikistan with Group 5 medications

Prevention of Hearing Loss in Patients with Multidrug-Resistant Tuberculosis