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Journal Article > ResearchFull Text

Open Forum Infect Dis. 2015 July 24; Volume 2 (Issue 3); DOI:10.1093/ofid/ofv111

Mwanga-Amumpaire J, Carroll R, Baudin E, Kemigisha E, Nampijja D, et al.

Open Forum Infect Dis. 2015 July 24; Volume 2 (Issue 3); DOI:10.1093/ofid/ofv111

Abstract
Background. Children with cerebral malaria (CM) have high rates of mortality and neurologic sequelae. Nitric oxide (NO) metabolite levels in plasma and urine are reduced in CM.
Methods. This randomized trial assessed the efficacy of inhaled NO versus nitrogen (N2) as an adjunctive treatment for CM patients receiving intravenous artesunate. We hypothesized that patients treated with NO would have a greater increase of the malaria biomarker, plasma angiopoietin-1 (Ang-1) after 48 hours of treatment.
Results. Ninety-two children with CM were randomized to receive either inhaled 80 part per million NO or N2 for 48 or more hours. Plasma Ang-1 levels increased in both treatment groups, but there was no difference between the groups at 48 hours (P = not significant [NS]). Plasma Ang-2 and cytokine levels (tumor necrosis factor-α, interferon-γ, interleukin [IL]-1β, IL-6, IL-10, and monocyte chemoattractant protein-1) decreased between inclusion and 48 hours in both treatment groups, but there was no difference between the groups (P = NS). Nitric oxide metabolite levels—blood methemoglobin and plasma nitrate—increased in patients treated with NO (both P < .05). Seven patients in the N2 group and 4 patients in the NO group died. Five patients in the N2 group and 6 in the NO group had neurological sequelae at hospital discharge.
Conclusions. Breathing NO as an adjunctive treatment for CM for a minimum of 48 hours was safe, increased blood methemoglobin and plasma nitrate levels, but did not result in a greater increase of plasma Ang-1 levels at 48 hours.

Journal Article > CommentaryFull Text

BMJ Glob Health. 2024 September 10; Volume 9 (Issue 9); e015862.; DOI:10.1136/bmjgh-2024-015862

Gleeson B, Ferreyra C, Palamountain K, Jacob ST, Spotswood N, et al.

BMJ Glob Health. 2024 September 10; Volume 9 (Issue 9); e015862.; DOI:10.1136/bmjgh-2024-015862

2 result(s)

Sort By

Journal Article > ResearchFull Text

Open Forum Infect Dis. 2015 July 24; Volume 2 (Issue 3); DOI:10.1093/ofid/ofv111

Mwanga-Amumpaire J, Carroll R, Baudin E, Kemigisha E, Nampijja D, et al.

Open Forum Infect Dis. 2015 July 24; Volume 2 (Issue 3); DOI:10.1093/ofid/ofv111

Journal Article > CommentaryFull Text

BMJ Glob Health. 2024 September 10; Volume 9 (Issue 9); e015862.; DOI:10.1136/bmjgh-2024-015862

Gleeson B, Ferreyra C, Palamountain K, Jacob ST, Spotswood N, et al.

BMJ Glob Health. 2024 September 10; Volume 9 (Issue 9); e015862.; DOI:10.1136/bmjgh-2024-015862

Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial

A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries

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Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial

A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries