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Copyright © Médecins Sans Frontières
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Showing 1 - 20 of 25 Items
Showing 1 - 20 of 25 Items
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Research

Performance evaluation of the Mini-Lab, an all-in-one clinical bacteriology laboratory adapted to low-resource settings, in a district hospital in Central African Republic: a prospective descriptive study

Langendorf C, Ronat JB, Natale A, Vidal T, Kodo H,  et al.
2025-07-29 • International Journal of Infectious Diseases
2025-07-29 • International Journal of Infectious Diseases

BACKGROUND

Médecins sans Frontières designed an all-in-one microbiology laboratory (the "Mini-Lab") to improve bacterial infections diagnosis in low-r...

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Impact of antimicrobial resistance in Middle Eastern settings

Truppa C, Ronat JB, Karah N, Shomar RA
2021-08-25 • MSF Scientific Days Asia 2021
2021-08-25 • MSF Scientific Days Asia 2021
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Evaluation of InTray cassettes directly from blood cultures for the diagnosis of sepsis in clinical bacteriology laboratories as an alternative to classic culture media

Natale A, Oueslati S, Rochard A, Lopez-Baez D, Ombelet S,  et al.
2023-01-31 • Diagnostics
2023-01-31 • Diagnostics
Culture media is fundamental in clinical bacteriology for the detection and isolation of bacterial pathogens. However, in-house media preparation could be challenging in low-resource set...

Highly drug-resistant pathogens implicated in burn-associated bacteremia in an Iraqi burn care unit

Ronat JB, Kakol J, Khoury M, Yun O, Brown V,  et al.
2014-08-11 • PLOS One
2014-08-11 • PLOS One
In low- and middle-income countries, bloodstream infections are an important cause of mortality in patients with burns. Increasingly implicated in burn-associated infections are highly d...

AMR in low-resource settings: Médecins Sans Frontières bridges surveillance gaps by developing a turnkey solution, the Mini-Lab

Ronat JB, Natale A, Kesteman T, Andremont A, Elamin W,  et al.
2021-10-01 • Clinical Microbiology and Infection
2021-10-01 • Clinical Microbiology and Infection
BACKGROUND
In low- and middle-income countries (LMICs), data related to antimicrobial resistance (AMR) are often inconsistently collected. Humanitarian, private and non-governmental ...

Clinical bacteriology in low-resource settings: today’s solutions

Ombelet S, Ronat JB, Walsh T, Yansouni CP, Cox J,  et al.
2018-08-01 • Lancet Infectious Diseases
2018-08-01 • Lancet Infectious Diseases
Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference laborat...

Antibiotic resistance in West Africa: a systematic review and meta-analysis

Bernabe KJ, Langendorf C, Ford NP, Ronat JB
2017-07-10 • International Journal of Antimicrobial Agents
2017-07-10 • International Journal of Antimicrobial Agents
Growing data suggest that antimicrobial-resistant bacterial infections are common in low- and middle-income countries. This review summarises the microbiology of key bacterial syndromes ...

Culture media for clinical bacteriology in low- and middle-income countries: challenges, best practices for preparation and recommendations for improved access

Orekan J, Barbe B, Oeng S, Ronat JB, Letchford J,  et al.
2021-05-18 • Clinical Microbiology and Infection
2021-05-18 • Clinical Microbiology and Infection
BACKGROUND
Culture media are fundamental in clinical microbiology. In laboratories in low- and middle-income countries (LMICs), they are mostly prepared in-house, which is challengin...

Considerations in evaluating equipment-free blood culture bottles: A short protocol for use in low-resource settings

Ombelet S, Natale A, Ronat JB, Vandenberg O, Jacobs J,  et al.
2022-04-25 • PLOS One
2022-04-25 • PLOS One
Use of equipment-free, “manual” blood cultures is still widespread in low-resource settings, as requirements for implementation of automated systems are often not met. Quality of manual ...

Biphasic versus monophasic manual blood culture bottles for low-resource settings: an in-vitro study

Ombelet S, Natale A, Ronat JB, Kesteman T, Vandenberg O,  et al.
2021-12-13 • Lancet Microbe
2021-12-13 • Lancet Microbe
BACKGROUND
Manual blood culture bottles (BCBs) are frequently used in low-resource settings. There are few BCB performance evaluations, especially evaluations comparing them with aut...

Validation of three MicroScan® antimicrobial susceptibility testing plates designed for low-resource settings

Ronat JB, Oueslati S, Natale A, Kesteman T, Elamin W,  et al.
2022-08-30 • Diagnostics
2022-08-30 • Diagnostics
Easy and robust antimicrobial susceptibility testing (AST) methods are essential in clinical bacteriology laboratories (CBL) in low-resource settings (LRS). We evaluated the Beckman Coul...

Development of an all-in-one transportable clinical bacteriology laboratory: feedback from testing a mini-lab prototype

Ronat JB, Natale A, Rochard A, Boillot B, Hubert J,  et al.
2019-05-08 • MSF Scientific Days International 2019
2019-05-08 • MSF Scientific Days International 2019
INTRODUCTION
Within MSF projects, many patients we treat have invasive bacterial infections, often in settings with increasing levels of antimicrobial resistance. However these proje...

Invasive infection and outcomes in a humanitarian surgical burn program in Haiti

Murphy RA, Nisenbaum L, Labar AS, Sheridan RL, Ronat JB,  et al.
2016-02-25 • World Journal of Surgery
2016-02-25 • World Journal of Surgery
BACKGROUND
Compared to high-income settings, survival in burn units in low-income settings is lower with invasive infections one leading cause of death. Médecins Sans Frontières is i...

The Mini-Lab: accessible clinical bacteriology for low-resource settings

Natale A, Ronat JB, Mazoyer A, Rochard A, Boillot B,  et al.
2020-06-01 • Lancet Microbe
2020-06-01 • Lancet Microbe

Evaluating ten commercially-available SARS-CoV-2 rapid serological tests using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) method

Dortet L, Ronat JB, Vauloup-Fellous C, Langendorf C, Mendeis DA,  et al.
2020-11-25 • Journal of Clinical Microbiology
2020-11-25 • Journal of Clinical Microbiology
Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are sca...

Best practices of blood cultures in low- and middle-income countries

Ombelet S, Barbe B, Affolabi D, Ronat JB, Lompo P,  et al.
2019-06-18 • Frontiers in Medicine
2019-06-18 • Frontiers in Medicine
Bloodstream infections (BSI) have a substantial impact on morbidity and mortality worldwide. Despite scarcity of data from many low- and middle-income countries (LMICs), there is increas...

Multidrug-resistant surgical site infections in a humanitarian surgery project

Murphy RA, Okoli O, Essien I, Teicher CL, Elder G,  et al.
2016-08-11 • Epidemiology and Infection
2016-08-11 • Epidemiology and Infection
The epidemiology of surgical site infections (SSIs) in surgical programmes in sub-Saharan Africa is inadequately described. We reviewed deep and organ-space SSIs occurring within a traum...

Post-traumatic osteomyelitis in Middle Eastwar-wounded civilians: resistance to first-line antibiotics in selected bacteria over the decade 2006–2016

Fily F, Ronat JB, Malou N, Kanapathipillai R, Seguin C,  et al.
2019-01-31 • BMC Infectious Diseases
2019-01-31 • BMC Infectious Diseases
BACKGROUND
War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of...

Clinical bacteriology in low-resource settings: today's solutions

Ombelet S, Ronat JB, Walsh T, Yansouni CP, Cox J,  et al.
2018-03-05 • Lancet Infectious Diseases
2018-03-05 • Lancet Infectious Diseases
Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference laborat...

Development of an all-in-one transportable clinical bacteriology laboratory: feedback from testing a mini-Lab prototype

Ronat JB, Natale A, Rochard A, Boillot B, Hubert J,  et al.
2019-05-08 • MSF Scientific Days International 2019
2019-05-08 • MSF Scientific Days International 2019