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Copyright © Médecins Sans Frontières
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Showing 1 - 11 of 11 Items
Showing 1 - 11 of 11 Items
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Journal Article
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Research

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes

Balasegaram M, Young H, Chappuis F, Priotto G, Raguenaud ME,  et al.
2008-10-21 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-10-21 • Transactions of the Royal Society of Tropical Medicine and Hygiene
This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontièr...
Journal Article
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Research

Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda

Checchi F, Piola P, Kosack CS, Ardizzoni E, Klarkowski DB,  et al.
2004-04-01 • Tropical Medicine and International Health
2004-04-01 • Tropical Medicine and International Health
We report below an in vivo antimalarial efficacy study conducted in 2002 in Bundi Bugyo, a district of western Uganda housing a large displaced population. We tested sulfadoxine-pyrimeth...
Journal Article
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Research

Nifurtimox-eflornithine Combination Therapy for Second-Stage Trypanosoma Brucei Gambiense Sleeping Sickness: A Randomized Clinical Trial in Congo

Priotto G, Kasparian S, Ngouama D, Ghorashian S, Arnold U,  et al.
2007-12-01 • Clinical Infectious Diseases
2007-12-01 • Clinical Infectious Diseases
BACKGROUND: Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for patients with second-stage disease are either highly to...
Journal Article
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Commentary

NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

Yun O, Priotto G, Tong J, Flevaud L, Chappuis F
2010-05-25 • PLOS Neglected Tropical Diseases
2010-05-25 • PLOS Neglected Tropical Diseases
Journal Article
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Research

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment

Mugittu K, Priotto G, Guthmann JP, Kiguli J, Adjuik M,  et al.
2007-02-01 • Tropical Medicine and International Health
2007-02-01 • Tropical Medicine and International Health
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115)...
Journal Article
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Research

Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda

Guthmann JP, Ruiz A, Priotto G, Kiguli J, Bonte L,  et al.
2008-02-14 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-02-14 • Transactions of the Royal Society of Tropical Medicine and Hygiene
A study was conducted to measure the overall performance of several rapid diagnostic tests for Plasmodium falciparum infection, in order to select the most appropriate test to be used in...
Journal Article
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Research

Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial

Priotto G, Kabakyenga JK, Pinoges LLP, Ruiz A, Eriksson T,  et al.
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerabi...
Journal Article
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Research

Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis

Checchi F, Chappuis F, Karunakara U, Priotto G, Chandramohan D
2011-07-05 • PLOS Neglected Tropical Diseases
2011-07-05 • PLOS Neglected Tropical Diseases
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and...
Journal Article
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Research

Early prediction of treatment efficacy in Second-Stage Gambiense Human African Trypanosomiasis

Priotto G, Chappuis F, Bastard M, Flevaud L, Etard JF
2012-06-05 • PLOS Neglected Tropical Diseases
2012-06-05 • PLOS Neglected Tropical Diseases
Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in ...
Journal Article
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Research

Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

Priotto G, Pinoges LLP, Fursa IB, Burke B, Nicolay N,  et al.
2008-03-05 • British Medical Journal (BMJ)
2008-03-05 • British Medical Journal (BMJ)
Objective: To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis. Design: Cohort study. Setting: Control programme in Ibba, sou...
Journal Article
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Commentary

The Unknown Risk of Vertical Transmission in Sleeping Sickness--a Literature Review

Lindner AK, Priotto G
2010-12-21 • PLOS Neglected Tropical Diseases
2010-12-21 • PLOS Neglected Tropical Diseases
Children with human African trypanosomiasis (HAT) present with a range of generally non-specific symptoms. Late diagnosis is frequent with often tragic outcomes. Trypanosomes can infect ...