The state of Bihar in India carries the largest share of the world's burden of antimony-resistant visceral leishmaniasis. We analysed clinical studies done in Bihar with different treatm...
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Olayinka A, Bourner J, Akpede GO, Okoeguale J, Abejegah C, et al.
2022-01-06 • PLOS Neglected Tropical Diseases
2022-01-06 • PLOS Neglected Tropical Diseases
BACKGROUND Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is...
Dahal P, Singh-Phulgenda S, Maguire BJ, Harriss E, Ritmeijer KKD, et al.
2021-08-10 • PLOS Neglected Tropical Diseases
2021-08-10 • PLOS Neglected Tropical Diseases
BACKGROUND Reports on the occurrence and outcome of Visceral Leishmaniasis (VL) in pregnant women is rare in published literature. The occurrence of VL in pregnancy is not systematic...
Zachariah R, Rust S, Berger SD, Guillerm N, Bissell K, et al.
2016-08-09 • PLOS One
2016-08-09 • PLOS One
Research capacity is weakest in low and middle-income countries (LMICs) where operational research is highly relevant and needed. Structured Operational Research and Training Initiative ...
Pedrique B, Strub-Wourgaft N, Some C, Olliaro PL, Trouiller P, et al.
2013-12-01 • Lancet Global Health
2013-12-01 • Lancet Global Health
In 1975-99, only 1·1% of new therapeutic products had been developed for neglected diseases. Since then, several public and private initiatives have attempted to mitigate this imbalance....
Olliaro PL, Pinoges LLP, Checchi F, Vaillant M, Guthmann JP
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: Parasites may recur asymptomatically after initial clearance by antimalarial treatment. Current guidelines recommend treatment only when patients develop symptoms or at the en...
Mugittu K, Priotto G, Guthmann JP, Kiguli J, Adjuik M, et al.
2007-02-01 • Tropical Medicine and International Health
2007-02-01 • Tropical Medicine and International Health
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115)...
Good quality, timely data are the cornerstone of health systems, but in many countries these data are not used for evidence-informed decision making and/or for improving public health. T...
WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J, et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Guthmann JP, Pinoges LLP, Checchi F, Cousens S, Balkan S, et al.
2006-11-01 • Antimicrobial Agents and Chemotherapy
2006-11-01 • Antimicrobial Agents and Chemotherapy
The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy ...
Quaglio GL, Pizzol D, Isaakidis P, Bortolani A, Tognon F, et al.
2019-05-20 • American Journal of Tropical Medicine and Hygiene
2019-05-20 • American Journal of Tropical Medicine and Hygiene
Breast tuberculosis (TB) is rarely reported and poorly described. This review aims to update the existing literature on risk factors, clinical presentations, constitutional symptoms, dia...
Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F, et al.
2008-08-09 • Malaria Journal
2008-08-09 • Malaria Journal
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...
Priotto G, Kabakyenga JK, Pinoges LLP, Ruiz A, Eriksson T, et al.
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerabi...
Torreele E, Boum Y, Adjaho I, Alé FGB, Issoufou SH, et al.
2023-01-19 • Lancet Infectious Diseases
2023-01-19 • Lancet Infectious Diseases
Three years since proving effective for Ebola virus disease in a clinical trial, two breakthrough treatments are registered and stockpiled in the USA but still not registered and general...
