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Showing 1 - 20 of 27 Items
Showing 1 - 20 of 27 Items
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Journal Article
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Letter

On the importance and challenges of global access to proven life-saving treatments for Ebolavirus – Authors' reply

Torreele E, Boum Y, Adjaho I, Alé FGB, Issoufou SH,  et al.
2023-04-01 • Lancet Infectious Diseases
2023-04-01 • Lancet Infectious Diseases
Journal Article
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Commentary

Breakthrough treatments for Ebola virus disease, but no access—what went wrong, and how can we do better?

Torreele E, Boum Y, Adjaho I, Alé FGB, Issoufou SH,  et al.
2023-01-19 • Lancet Infectious Diseases
2023-01-19 • Lancet Infectious Diseases
Three years since proving effective for Ebola virus disease in a clinical trial, two breakthrough treatments are registered and stockpiled in the USA but still not registered and general...
Journal Article
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Research

Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004

Olliaro PL, Guerin PJ, Gerstl S, Haaskjold AA, Rottingen JA,  et al.
2005-12-01 • Lancet Infectious Diseases
2005-12-01 • Lancet Infectious Diseases
The state of Bihar in India carries the largest share of the world's burden of antimony-resistant visceral leishmaniasis. We analysed clinical studies done in Bihar with different treatm...
Journal Article
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Research

A standardised phase III clinical trial framework to assess therapeutic interventions for Lassa fever

Olayinka A, Bourner J, Akpede GO, Okoeguale J, Abejegah C,  et al.
2022-01-06 • PLOS Neglected Tropical Diseases
2022-01-06 • PLOS Neglected Tropical Diseases
BACKGROUND
Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is...
Journal Article
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Research

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Journal Article
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Research

Building Global Capacity for Conducting Operational Research Using the SORT IT Model: Where and Who?

Zachariah R, Rust S, Berger SD, Guillerm N, Bissell K,  et al.
2016-08-09 • PLOS One
2016-08-09 • PLOS One
Research capacity is weakest in low and middle-income countries (LMICs) where operational research is highly relevant and needed. Structured Operational Research and Training Initiative ...
Journal Article
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Review

Visceral leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

Dahal P, Singh-Phulgenda S, Maguire BJ, Harriss E, Ritmeijer KKD,  et al.
2021-08-10 • PLOS Neglected Tropical Diseases
2021-08-10 • PLOS Neglected Tropical Diseases
BACKGROUND
Reports on the occurrence and outcome of Visceral Leishmaniasis (VL) in pregnant women is rare in published literature. The occurrence of VL in pregnancy is not systematic...
Journal Article
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Short Report

An open source pharma roadmap

Balasegaram M, Kolb P, McKew J, Menon J, Olliaro PL,  et al.
2017-04-18 • PLOS Medicine
2017-04-18 • PLOS Medicine
Journal Article
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Research

The drug and vaccine landscape for neglected diseases (2000-11): a systematic assessment

Pedrique B, Strub-Wourgaft N, Some C, Olliaro PL, Trouiller P,  et al.
2013-12-01 • Lancet Global Health
2013-12-01 • Lancet Global Health
In 1975-99, only 1·1% of new therapeutic products had been developed for neglected diseases. Since then, several public and private initiatives have attempted to mitigate this imbalance....
Journal Article
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Research

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment

Mugittu K, Priotto G, Guthmann JP, Kiguli J, Adjuik M,  et al.
2007-02-01 • Tropical Medicine and International Health
2007-02-01 • Tropical Medicine and International Health
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115)...
Journal Article
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Research

Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment

Olliaro PL, Pinoges LLP, Checchi F, Vaillant M, Guthmann JP
2008-01-01 • Tropical Medicine and International Health
2008-01-01 • Tropical Medicine and International Health
OBJECTIVE: Parasites may recur asymptomatically after initial clearance by antimalarial treatment. Current guidelines recommend treatment only when patients develop symptoms or at the en...
Journal Article
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Research

Methodological issues in the assessment of antimalarial drug treatment: Analysis of 13 studies in eight African countries from 2001 to 2004

Guthmann JP, Pinoges LLP, Checchi F, Cousens S, Balkan S,  et al.
2006-11-01 • Antimicrobial Agents and Chemotherapy
2006-11-01 • Antimicrobial Agents and Chemotherapy
The objectives of these analyses were to assess the feasibility of the latest WHO recommendations (28-day follow-up with PCR genotyping) for the assessment of antimalarial drug efficacy ...
Journal Article
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Commentary

Neglected tropical diseases and the sustainable development goals: an urgent call for action from the front line

Addisu A, Adriaensen W, Balew A, Asfaw M, Diro EGJ,  et al.
2019-02-08 • BMJ Global Health
2019-02-08 • BMJ Global Health
SUMMARY BOX

The international community has pledged through the Sustainable Development Goals to eliminate neglected tropical diseases by 2030.

Authors from 19 institut...
Journal Article
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Research

Building the capacity of public health programmes to become data rich, information rich and action rich

Harries AD, Khogali MA, Kumar AMV, Satyanarayana S, Takarinda KC,  et al.
2018-06-21 • Public Health Action
2018-06-21 • Public Health Action
Good quality, timely data are the cornerstone of health systems, but in many countries these data are not used for evidence-informed decision making and/or for improving public health. T...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Journal Article
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Review

Breast Tuberculosis in Women: A Systematic Review

Quaglio GL, Pizzol D, Isaakidis P, Bortolani A, Tognon F,  et al.
2019-05-20 • American Journal of Tropical Medicine and Hygiene
2019-05-20 • American Journal of Tropical Medicine and Hygiene
Breast tuberculosis (TB) is rarely reported and poorly described. This review aims to update the existing literature on risk factors, clinical presentations, constitutional symptoms, dia...
Journal Article
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Review

Breast tuberculosis in men: A systematic review

Quaglio GL, Pizzol D, Bortolani A, Manenti F, Isaakidis P,  et al.
2018-04-03 • PLOS One
2018-04-03 • PLOS One
SETTING
Breast tuberculosis in male is a rarely reported and poorly described condition.

OBJECTIVE
To quantify the number of breast tuberculosis in men, to describe clin...
Journal Article
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Research

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

Ashley EA, Pinoges LLP, Turyakira E, Dorsey G, Checchi F,  et al.
2008-08-09 • Malaria Journal
2008-08-09 • Malaria Journal
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with im...
Journal Article
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Research

Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda: a randomized, double-blind, placebo-controlled trial

Priotto G, Kabakyenga JK, Pinoges LLP, Ruiz A, Eriksson T,  et al.
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2008-01-25 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Drug-resistant malaria is spreading in Africa. The few available drugs might be safeguarded if combined with an artemisinin derivative. We investigated the efficacy, safety, and tolerabi...
Journal Article
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Research

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up

Stepniewska K, Taylor WRJ, Mayxay M, Price RN, Smithuis FM,  et al.
2004-11-01 • Antimicrobial Agents and Chemotherapy
2004-11-01 • Antimicrobial Agents and Chemotherapy
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with foll...