Search Results | MSF Science Portal

Journal Article

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Research

Rasti R, Kumbakumba E, Nanjebe D, Mlotshwa P, Nassejje M, et al.

2025-03-22 • BMC Infectious Diseases

BACKGROUND

In low-resource settings, limited laboratory capacity adds to the burden of central nervous system (CNS) infections in children and spurs overuse of ...

Journal Article

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Research

Kimathi D, Juan-Giner A, Bob NS, Orindi B, Namulwana ML, et al.

2025-02-20 • New England Journal of Medicine

BACKGROUND

Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain u...

Journal Article

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Research

Boyce RM, Ndizeye R, Ngelese H, Baguma E, Shem B, et al.

2023-03-27 • PLOS Global Public Health

Barriers continue to limit access to viral load (VL) monitoring across sub-Saharan Africa adversely impacting control of the HIV epidemic. The objective of this study was to determine wh...

Journal Article

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Research

Bonnet MMB, Nordholm AC, Ssekyanzi B, Byamukama O, Orikiriza P, et al.

2023-03-23 • Pediatrics

BACKGROUND AND OBJECTIVES:
Children experience high tuberculosis (TB)-related mortality but causes of death among those with presumptive TB are poorly documented. We describe the mor...

Journal Article

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Research

Lynch E, Jensen TO, Assao B, Chihana ML, Turuho T, et al.

2022-09-09 • Malaria Journal

BACKGROUND
Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein ...

Journal Article

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Research

Ardizzoni E, Orikiriza P, Ssuuna C, Nyehangane D, Gumsboga M, et al.

2019-10-16 • Journal of Clinical Microbiology

Background: Xpert MTB/RIF (Xpert) and culture are the most reliable methods for tuberculosis diagnosis but are still poorly accessible in many low resource countries. We aimed to assess ...

Journal Article

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Research

Orikiriza P, Nyehangane D, Atwine D, Kisakye JJ, Kassaza K, et al.

2017-03-31 • East African Medical Journal

BACKGROUND
To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that ...

Journal Article

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Research

Dhorda M, Piola P, Nyehangane D, Tumwebaze B, Nalusaji A, et al.

2012-01-01 • PLOS One

Abstract. Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich ...

Journal Article

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Research

Boum Y II, Kim S, Orikiriza P, Acuña-Villaorduña C, Vinhas S, et al.

2016-03-30 • Journal of Clinical Microbiology

Sputum acid-fast bacilli (AFB) smear microscopy has suboptimal sensitivity but remains the most commonly used laboratory test to diagnose pulmonary tuberculosis (TB). We prospectively ev...

Journal Article

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Research

Orikiriza P, Nansumba M, Nyehangane D, Bastard M, Mugisha IT, et al.

2018-05-08 • European Journal of Clinical Microbiology and Infectious Diseases

The Xpert MTB/RIF assay is a major advance for diagnosis of tuberculosis (TB) in high-burden countries but is limited in children by their difficulty to produce sputum. We investigated T...

Journal Article

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Research

Nackers F, Cohuet S, le Polain de Waroux O, Langendorf C, Nyehangane D, et al.

2017-09-18 • Vaccine

BACKGROUND
Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact. The 10-va...

Journal Article

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Research

Migisha R, Nyehangane D, Boum Y II, Page AL, Zuniga-Ripa A, et al.

2018-10-18 • Scientific Reports

Human brucellosis, a chronic disease contracted through contact with animals and consuption of unpasteurized dairy products is underreported in limited-resource countries. This cross-sec...

Journal Article

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Research

Juan-Giner A, Kimathi D, Grantz KH, Hamaluba M, Kazooba P, et al.

2021-01-09 • Lancet

BACKGROUND
Stocks of yellow fever vaccine are insufficient to cover exceptional demands for outbreak response. Fractional dosing has shown efficacy, but evidence is limited to the 17...

Journal Article

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Research

Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B, et al.

2012-05-03 • Malaria Journal

BACKGROUND
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, rando...

Journal Article

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Research

Mwanga-Amumpaire J, Carroll R, Baudin E, Kemigisha E, Nampijja D, et al.

2015-07-24 • Open Forum Infectious Diseases

Abstract
Background. Children with cerebral malaria (CM) have high rates of mortality and neurologic sequelae. Nitric oxide (NO) meta...

Journal Article

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Research

Orikiriza P, Smith JS, Ssekyanzi B, Nyehangane D, Mugisha IT, et al.

2021-06-17 • European Respiratory Journal

BACKGROUND
Non-sputum-based diagnostic approaches are crucial in children at high risk of disseminated tuberculosis (TB) who cannot expectorate sputum. We evaluated the diagnostic ac...

Journal Article

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Research

Boyce RM, Muhindo E, Baguma E, Muhindo R, Shem B, et al.

2022-02-23 • Malaria Journal

BACKGROUND
Progress against malaria has stalled and may even be slipping backwards in high-burden countries. This is due to a range of factors including insecticide resistance and mo...

Journal Article

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Commentary

Ariza-Vioque E, Ello F, Andriamamonjisoa H, Machault V, González-Martín J, et al.

2022-06-29 • Infectious Diseases and Therapy

Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected...

Journal Article

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Research

Murungi M, Fulton T, Reyes R, Matte M, Ntaro M, et al.

2017-05-01 • Journal of Clinical Microbiology

Poor specificity may negatively impact rapid diagnostic test (RDT)-based diagnostic strategies for malaria. We performed real-time PCR on a subset of subjects who had undergone diagnosti...

Journal Article

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Research

Bebell LM, Ngonzi J, Bazira J, Fajardo Y, Boatin AA, et al.

2017-04-13 • PLOS One

INTRODUCTION
Puerperal sepsis causes 10% of maternal deaths in Africa, but prospective studies on incidence, microbiology and antimicrobial resistance are lacking.

METHODS

Science Portal

Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting – a prospective study in southwestern Uganda

Low-dose yellow fever vaccine in adults in Africa

It takes more than a machine: A pilot feasibility study of point-of-care HIV-1 viral load testing at a lower-level health center in rural western Uganda

Mortality and cause of death in children with presumptive disseminated tuberculosis

Evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria and prevalence of pfhrp2/3 deletions in Aweil, South Sudan

Evaluation of OMNIgene® SPUTUM and ethanol reagent for preservation of sputum prior to Xpert and culture testing in Uganda

Evaluation of the SD Bioline TB Ag MPT64 test for identification of Mycobacterium tuberculosis complex from liquid cultures in southwestern Uganda

Performance of a Histidine-Rich Protein 2 Rapid Diagnostic Test, Paracheck Pf(R), for Detection of Malaria Infections in Ugandan Pregnant Women

Diagnostic accuracy of the small membrane filtration method for diagnosis of pulmonary tuberculosis in a high HIV prevalence setting

Xpert MTB/RIF diagnosis of childhood tuberculosis from sputum and stool samples in a high TB-HIV-prevalent setting

Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: a population-based cross-sectional study in South Western Uganda, 2014

Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda

Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial

Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial

Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children

Permethrin-treated baby wraps for the prevention of malaria: results of a randomized controlled pilot study in rural Uganda

Capacity building in sub-Saharan Africa as part of the INTENSE-TBM project during the COVID-19 pandemic

Improving the specificity of Plasmodium falciparum malaria diagnosis in high-transmission settings with a two-step rapid diagnostic test and microscopy algorithm

Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital