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Journal Article > ResearchFull Text

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

PLOS Med. 1 March 2016; Volume 13 (Issue 3); DOI:10.1371/journal.pmed.1001967
Sissoko D, Laouenan C, Folkesson E, M’Lebing A, Beavogui A,  et al.
PLOS Med. 1 March 2016; Volume 13 (Issue 3); DOI:10.1371/journal.pmed.1001967
Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health Organization released a short list of drugs suitable for EVD research. Favipiravir, an antiviral developed for the treatment of severe influenza, was one of these. In late 2014, the conditions for starting a randomized Ebola trial were not fulfilled for two reasons. One was the perception that, given the high number of patients presenting simultaneously and the very high mortality rate of the disease, it was ethically unacceptable to allocate patients from within the same family or village to receive or not receive an experimental drug, using a randomization process impossible to understand by very sick patients. The other was that, in the context of rumors and distrust of Ebola treatment centers, using a randomized design at the outset might lead even more patients to refuse to seek care. Therefore, we chose to conduct a multicenter non-randomized trial, in which all patients would receive favipiravir along with standardized care. The objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large Ebola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with EVD. The trial was not aimed at directly informing future guidelines on Ebola treatment but at quickly gathering standardized preliminary data to optimize the design of future studies.More
Journal Article > CommentaryFull Text

An epidemic of suspicion - Ebola and violence in the DRC

N Engl J Med. 4 April 2019; Volume 380 (Issue 14); 1298-1299.; DOI:10.1056/NEJMp1902682
Nguyen VN
N Engl J Med. 4 April 2019; Volume 380 (Issue 14); 1298-1299.; DOI:10.1056/NEJMp1902682
Journal Article > ReviewFull Text

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

PLOS Med. 2 March 2016; Volume 13 (Issue 3); e1001965.; DOI:10.1371/journal.pmed.1001965
Lienhardt C, Lonnroth K, Menzies D, Balasegaram M, Chakaya JM,  et al.
PLOS Med. 2 March 2016; Volume 13 (Issue 3); e1001965.; DOI:10.1371/journal.pmed.1001965
Christian Lienhardt and colleagues describe the research efforts needed to end the global tuberculosis epidemic by 2035.