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Showing 1 - 10 of 10 Items
Showing 1 - 10 of 10 Items
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Research

High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV

Bonnet MMB, Gabillard D, Domoua SK, Muzoora C, Messou E,  et al.
2023-03-08 • Clinical Infectious Diseases
2023-03-08 • Clinical Infectious Diseases
BACKGROUND
In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the perf...
Journal Article
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Research

Higher Art Adherence is Associated with Lower Systemic Inflammation in Treatment-Naïve Ugandans Who Achieve Virologic Suppression

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Research
Conference Material
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Castillo-Mancilla JR, Morrow M, Boum Y II, Byakwaga H, Haberer JE,  et al.
2018-01-16 • Journal of Acquired Immune Deficiency Syndromes (1999)
2018-01-16 • Journal of Acquired Immune Deficiency Syndromes (1999)
Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes. We aimed to evaluate the association between A...

Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda

Bebell LM, Kembabazi A, Musinguzi N, Martin JN, Hunt PW,  et al.
2021-12-01 • SSM - Mental Health
2021-12-01 • SSM - Mental Health
Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies...

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Muzoora C
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Blanc FX, Badje AD, Bonnet MMB, Gabillard D, Messou E,  et al.
2020-06-18 • New England Journal of Medicine
2020-06-18 • New England Journal of Medicine
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...

Capacity building in sub-Saharan Africa as part of the INTENSE-TBM project during the COVID-19 pandemic

Ariza-Vioque E, Ello F, Andriamamonjisoa H, Machault V, González-Martín J,  et al.
2022-06-29 • Infectious Diseases and Therapy
2022-06-29 • Infectious Diseases and Therapy
Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected...

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy

Byakwaga H, Huang Y, Muzoora C, Kembabazi A, Weiser SD,  et al.
2014-02-28 • Journal of Infectious Diseases
2014-02-28 • Journal of Infectious Diseases
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and ot...

Antiretroviral therapy adherence interruptions are associated with systemic inflammation among Ugandans who achieved viral suppression

Musinguzi N, Castillo-Mancilla JR, Morrow M, Byakwaga H, Mawhinney S,  et al.
2019-12-01 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2019-12-01 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
BACKGROUND
Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression. We assessed the effect of antiretroviral therap...

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

Loyse A, Burry J, Cohn J, Ford NP, Chiller T,  et al.
2018-10-18 • Lancet Infectious Diseases
2018-10-18 • Lancet Infectious Diseases
In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated w...

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

Rao PS, Moore CC, Mbonde AA, Nuwagira E, Orikiriza P,  et al.
2021-06-18 • Antibiotics
2021-06-18 • Antibiotics
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to...