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Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 10 of 10 Items
Showing 1 - 10 of 10 Items
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Journal Article
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Research

High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV

Bonnet MMB, Gabillard D, Domoua SK, Muzoora C, Messou E,  et al.
2023-03-08 • Clinical Infectious Diseases
2023-03-08 • Clinical Infectious Diseases
BACKGROUND
In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the perf...
Journal Article
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Research

Higher Art Adherence is Associated with Lower Systemic Inflammation in Treatment-Naïve Ugandans Who Achieve Virologic Suppression

Castillo-Mancilla JR, Morrow M, Boum Y II, Byakwaga H, Haberer JE,  et al.
2018-01-16 • Journal of Acquired Immune Deficiency Syndromes (1999)
2018-01-16 • Journal of Acquired Immune Deficiency Syndromes (1999)
Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes. We aimed to evaluate the association between A...
Journal Article
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Research

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Blanc FX, Badje AD, Bonnet MMB, Gabillard D, Messou E,  et al.
2020-06-18 • New England Journal of Medicine
2020-06-18 • New England Journal of Medicine
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...
Journal Article
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Research

Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda

Bebell LM, Kembabazi A, Musinguzi N, Martin JN, Hunt PW,  et al.
2021-12-01 • SSM - Mental Health
2021-12-01 • SSM - Mental Health
Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies...
Conference Material
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Abstract

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Muzoora C
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
2022-06-29 • TB Research Dissemination Workshop, Epicentre Uganda
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...
Journal Article
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Commentary

Capacity building in sub-Saharan Africa as part of the INTENSE-TBM project during the COVID-19 pandemic

Ariza-Vioque E, Ello F, Andriamamonjisoa H, Machault V, González-Martín J,  et al.
2022-06-29 • Infectious Diseases and Therapy
2022-06-29 • Infectious Diseases and Therapy
Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected...
Journal Article
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Research

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy

Byakwaga H, Boum Y II, Huang Y, Muzoora C, Kembabazi A,  et al.
2014-02-28 • Journal of Infectious Diseases
2014-02-28 • Journal of Infectious Diseases
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and ot...
Journal Article
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Research

Antiretroviral therapy adherence interruptions are associated with systemic inflammation among Ugandans who achieved viral suppression

Musinguzi N, Castillo-Mancilla JR, Morrow M, Byakwaga H, Mawhinney S,  et al.
2019-12-01 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
2019-12-01 • Journal of Acquired Immune Deficiency Syndromes (JAIDS)
BACKGROUND
Residual systemic inflammation, which is associated with non-AIDS clinical outcomes, may persist despite viral suppression. We assessed the effect of antiretroviral therap...
Journal Article
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Commentary

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

Loyse A, Burry J, Cohn J, Ford NP, Chiller T,  et al.
2018-10-18 • Lancet Infectious Diseases
2018-10-18 • Lancet Infectious Diseases
In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated w...
Journal Article
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Research

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

Rao PS, Moore CC, Mbonde AA, Nuwagira E, Orikiriza P,  et al.
2021-06-18 • Antibiotics
2021-06-18 • Antibiotics
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to...