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Showing 1 - 4 of 4 Items
Showing 1 - 4 of 4 Items
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Journal Article
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Research

A standardised phase III clinical trial framework to assess therapeutic interventions for Lassa fever

Olayinka A, Bourner J, Akpede GO, Okoeguale J, Abejegah C,  et al.
2022-01-06 • PLOS Neglected Tropical Diseases
2022-01-06 • PLOS Neglected Tropical Diseases
BACKGROUND
Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is...
Journal Article
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Research
Journal Article
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Research
Journal Article
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Review

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

Sissoko D, Laouenan C, Folkesson E, M’Lebing A, Beavogui A,  et al.
2016-03-01 • PLOS Medicine
2016-03-01 • PLOS Medicine
Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health ...

Favipiravir Pharmacokinetics in Ebola-Infected Patients of the JIKI Trial Reveals Concentrations Lower Than Targeted

Nguyen TN, Guedj J, Anglaret X, Laouenan C, Madelain V,  et al.
2017-02-23 • PLOS Neglected Tropical Diseases
2017-02-23 • PLOS Neglected Tropical Diseases
In 2014-2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) in Guinea (JIKI trial). Because the drug had never been used before for thi...

Sleeping sickness

Malvy D, Chappuis F
2011-04-04 • Clinical Microbiology and Infection
2011-04-04 • Clinical Microbiology and Infection
Human African trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease that flourishes in impoverished, rural parts of sub-Saharan Africa. It is caused by infection with th...