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Copyright © Médecins Sans Frontières
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Showing 1 - 5 of 5 Items
Showing 1 - 5 of 5 Items
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Journal Article
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Research

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R,  et al.
2013-07-17 • Malaria Journal
2013-07-17 • Malaria Journal
BACKGROUND
Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.<...
Journal Article
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Research

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C,  et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Journal Article
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Research

Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R,  et al.
2013-07-17 • Malaria Journal
2013-07-17 • Malaria Journal
BACKGROUND
Prospective efficacy monitoring of anti-malarial treatments is imperative for timely detection of resistance development. The in vivo efficacy of artesunate-amodiaquine (A...
Journal Article
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Research

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia

Otienoburu SD, Maiga-Ascofare O, Schramm B, Jullien V, Jones JJ,  et al.
2016-09-05 • Malaria Journal
2016-09-05 • Malaria Journal
BACKGROUND
Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the differe...
Journal Article
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Research

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network

Hossain MS, Commons RJ, Douglas NM, Thriemer KL, Alemayehu BH,  et al.
2020-11-19 • PLOS Medicine
2020-11-19 • PLOS Medicine
Background: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using a...