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Review

Optimal anthropometric discharge criteria from treatment of wasting: meta-analysis of individual patient data from 34 studies

Bliznashka L, Chaudhary S, Rattigan SM, Isanaka S, Adah R,  et al.
2025-12-01 • American Journal of Clinical Nutrition
2025-12-01 • American Journal of Clinical Nutrition

BACKGROUND

Community-based treatment of acute malnutrition saves lives, but recovered children remain at risk of relapse postdischarge. Strategies to reduce thi...

Journal Article
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Research

Effect of prenatal multiple micronutrient supplements and medium-quantity lipid-based nutritional supplements on maternal weight gain and infant birth weight in rural Niger: a cluster-randomised trial

Rattigan SM, Garba S, Plikaytis B, Sudfeld C, 
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Guindo O, 
et al.
2025-11-03 • BMJ Global Health
2025-11-03 • BMJ Global Health

Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria

Ali NB, Hitchings MD, Berthé F, Aruna P, Shehu I,  et al.
2025-10-01 • BMJ Global Health
2025-10-01 • BMJ Global Health

INTRODUCTION

Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate ...

Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger

Sands K, Lankapalli AK, Lai G, Hassan B, Portal EA,  et al.
2025-08-01 • Nature Communications
2025-08-01 • Nature Communications

Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute...

Acceptability of a microbiome-directed food for the management of children with uncomplicated acute malnutrition in Maradi, Niger: Two randomized crossover trials

Rattigan SM, Mbouombouo IN, Abdou Tahirou MA, Mostafa I, Saqeeb KN,  et al.
2025-06-09 • Current Developments in Nutrition
2025-06-09 • Current Developments in Nutrition

BACKGROUND

A novel ready-to-use microbiome-directed food (MDF) has been developed for the management ...

Contribution of maternal adherence to the effect of multiple micronutrient supplementation during pregnancy: a systematic review and individual participant data meta-analysis

Smith ER, Gomes F, Adu-Afarwuah S, Aguayo VM, El Arifeen S,  et al.
2025-05-01 • Advances in Nutrition
2025-05-01 • Advances in Nutrition

Multiple micronutrient supplements (MMSs) in pregnancy reduces risk of infant low birthweight (LBW) and improves other maternal and infant outcom...

Prescribing practices in the treatment of wasting: secondary analysis from a randomised trial

Rattigan SM, Grantz KH, Hanson K, Langendorf C, Berthé F,  et al.
2024-02-26 • BMJ Nutrition, Prevention & Health
2024-02-26 • BMJ Nutrition, Prevention & Health
INTRODUCTION
Current guidelines for the outpatient treatment of severe acute malnutrition (SAM) recommend the provision of routine medications to all children at admission and prescr...

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F,  et al.
2023-10-19 • Lancet Microbe
2023-10-19 • Lancet Microbe
BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...

Prognostic value of different anthropometric indices over different measurement intervals to predict mortality in 6–59-month-old children

Briend A, Myatt M, Berkley JA, Black RE, Boyd EM,  et al.
2023-06-01 • Public Health Nutrition
2023-06-01 • Public Health Nutrition
OBJECTIVE
To compare the prognostic value of mid-upper arm circumference (MUAC), weight-for-height Z-score (WHZ) and weight-for-age Z-score (WAZ) for predicting death over periods of...

Analysis of postdischarge interventions for children treated for moderate or severe wasting, growth faltering or failure, or edema

Bliznashka L, Rattigan SM, Sudfeld CR, Isanaka S
2023-05-01 • JAMA Network Open
2023-05-01 • JAMA Network Open
IMPORTANCE
Children treated for acute malnutrition remain at increased risk of relapse, infection, and mortality after programmatic recovery. Global guidelines for the management of ...

Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution

Isanaka S, Kodish SR, Berthé F, Alley I, Nackers F,  et al.
2017-04-12 • American Journal of Clinical Nutrition
2017-04-12 • American Journal of Clinical Nutrition
BACKGROUND
Community-based management of severe acute malnutrition (SAM) has been shown to be safe and cost-effective, but program coverage remains low. Treatment models that maintai...

Acceptability and utilization of a lipid-based nutrient supplement formulated for pregnant women in rural Niger: a multi-methods study

Isanaka S, Kodish SR, Mamaty AA, Guindo O, Zeilani M,  et al.
2019-07-01 • BMC Nutrition
2019-07-01 • BMC Nutrition
Background
In food insecure settings, it may be difficult for pregnant women to meet increased nutritional needs through traditional diets. A promising new strategy to fill nutrient...

Amoxicillin for severe acute malnutrition in children

Isanaka S, Adehossi E, Grais RF
2016-07-14 • New England Journal of Medicine
2016-07-14 • New England Journal of Medicine

Estimating program coverage in the treatment of severe acute malnutrition: a comparative analysis of the validity and operational feasibility of two methods

Isanaka S, Hedt-Gauthier BL, Grais RF, Allen BGS
2018-07-03 • Population Health Metrics
2018-07-03 • Population Health Metrics
Many health programs can assess coverage using standardized cluster survey methods, but estimating the coverage of nutrition programs presents a special challenge due to low disease prev...

Conceptualizing factors impacting nutrition services coverage of treatment for acute malnutrition in children - an application of the Three Delays Model in Niger

Kodish SR, Allen BGS, Salou H, Schwendler TR, Isanaka S
2021-10-08 • Public Health Nutrition
2021-10-08 • Public Health Nutrition
OBJECTIVE
The Three Delays Model is a conceptual model traditionally used to understand contributing factors of maternal mortality. It posits that most barriers to health services ut...

Using MUAC as the sole anthropometric criterion for admission and discharge during outpatient treatment for Severe Acute Malnutrition : Niger Operational Experience

Isanaka S, Garba S, Cabrera ME, Rocaspana M
2021-05-18 • MSF Scientific Days International 2021: Research
2021-05-18 • MSF Scientific Days International 2021: Research

Immunogenicity of an oral rotavirus vaccine administered with prenatal nutritional support in Niger: A cluster randomized clinical trial

Isanaka S, Garba S, Plikaytis BD, McNeal MM, Guindo O,  et al.
2021-08-10 • PLOS Medicine
2021-08-10 • PLOS Medicine
BACKGROUND
Nutritional status may play a role in infant immune development. To identify potential boosters of immunogenicity in low-income countries where oral vaccine efficacy is lo...

Malaria and nutritional status among children with severe acute malnutrition in Niger: a prospective cohort study

Oldenburg CE, Guerin PJ, Berthé F, Grais RF, Isanaka S
2018-09-14 • Clinical Infectious Diseases
2018-09-14 • Clinical Infectious Diseases
BACKGROUND
The relationship between malaria infection and nutritional status is complex. Previous studies suggest malaria may increase the incidence and severity of malnutrition, whi...

A feasibility study using mid-upper arm circumference as the sole anthropometric criterion for admission and discharge in the outpatient treatment for severe acute malnutrition

Garba S, Salou H, Nackers F, Ayouba A, Guindo O,  et al.
2021-08-12 • BMC Nutrition
2021-08-12 • BMC Nutrition
BACKGROUND
The World Health Organization recommends the use of a weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC) as anthropometric criteria for the admissio...

Effectiveness of a monthly schedule of follow-up for the treatment of uncomplicated severe acute malnutrition in Sokoto, Nigeria: a cluster randomized crossover trial

Hitchings MD, Berthe F, Aruna P, Shehu I, Ali Hamza M,  et al.
2022-03-01 • PLOS Medicine
2022-03-01 • PLOS Medicine
BACKGROUND
Community-based management of severe acute malnutrition (SAM) involves weekly or biweekly outpatient clinic visits for clinical surveillance and distribution of therapeuti...