Search Results | MSF Science Portal

Journal Article

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Research

Kimathi D, Juan-Giner A, Bob NS, Orindi B, Namulwana ML, et al.

2025-02-20 • New England Journal of Medicine

BACKGROUND

Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain u...

Journal Article

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Research

Coldiron ME, Soumana I, Baudin E, Langendorf C, Mamiafo Tchoula C, et al.

2025-01-08 • Lancet Infectious Diseases

BACKGROUND

In settings with low pneumococcal conjugate vaccine (PCV) coverage, multi-age cohort mass campaigns could increase population immunity, and fractiona...

Journal Article

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Research

Kasonia K, Brindle H, Manno D, Edwards T, Gardais S, et al.

2024-12-05 • Frontiers in Global Women's Health

BACKGROUND

Conflict is known to impact maternal and neonatal health in Eastern Democratic Republic of the Congo (DRC), an area of longstanding insecurity. We co...

Journal Article

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Research

Choi EM, Kasonia K, Kavunga-Membo H, Mukadi-Bamuleka D, Soumah A, et al.

2024-07-26 • Vaccines

During the 2018–2020 Ebola virus disease outbreak in Democratic Republic of the Congo, a phase 3 trial of the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine (DRC-EB-001) commenced in Goma, wit...

Journal Article

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Research

Kavunga-Membo H, Watson-Jones D, Kasonia K, Edwards T, Camacho A, et al.

2024-07-23 • Vaccines

During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first stud...

Journal Article

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Research

Kimbugwe G, Vatrinet R, Mwanga JA, Kakuru R, Mpeirwe D, et al.

2024-04-01 • Vaccine

BACKGROUND
Understanding the knowledge, perception and attitudes towards Ebola vaccines is an important factor in ensuring future use of these vaccines. A qualitative methods study e...

Journal Article

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Book Chapter

Bausch DG, Kavunga-Membo H, Grais RF, Imbault N, Roberts N, et al.

2023-12-31 • Nephrology Dialysis Transplantation

Research, especially clinical trials, during outbreaks often poses enormous challenges, and up until very recent times was often considered almost impossible. However, for diseases su...

Journal Article

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Research

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F, et al.

2023-10-19 • Lancet Microbe

BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...

Journal Article

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Commentary

Kabore Y, Vatrinet R, Guindo O, Moussa SH, Schilling WHK, et al.

2023-09-06 • American Journal of Tropical Medicine and Hygiene

In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a rapidly emerging virus causing the coronavirus disease 2019 (COVID-19) pandemic, had no known effective prophylax...

Journal Article

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Research

Juan-Giner A, Namulwana ML, Kimathi D, Grantz KH, Fall G, et al.

2023-04-28 • Lancet Infectious Diseases

BACKGROUND
Current supply shortages constrain yellow fever vaccination activities, particularly outbreak response. Although fractional doses of all WHO-prequalified yellow fever vacc...

Journal Article

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Protocol

Penfold S, Adegnika AA, Asogun D, Ayodeji O, Azuogu BN, et al.

2023-03-30 • PLOS One

BACKGROUND
Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year. The true prevalence and i...

Journal Article

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Research

James M, Kasereka JG, Kasiwa B, Kavunga-Membo H, Kambale K, et al.

2023-03-15 • Social Science and Medicine

During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu. This prov...

Journal Article

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Research

Menzies NA, Berthé F, Hitchings MD, Aruna P, Hamza MA, et al.

2022-12-09 • PLOS Global Public Health

Severe acute malnutrition (SAM) is a major source of mortality for children in low resource settings. Alternative treatment models that improve acceptability and reduce caregiver burden ...

Journal Article

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Research

Simon JK, Kennedy SB, Mahon BE, Dubey SA, Grant-Klein RJ, et al.

2022-10-05 • Vaccine

BACKGROUND
ERVEBO®, a live recombinant vesicular stomatitis virus (VSV) vaccine containing the Zaire ebolavirus glycoprotein (GP) in place of the VSV GP (rVSVΔG-ZEBOV-GP), was advanc...

Journal Article

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Research

Debellut F, Tang K, Clark A, Pecenka C, Assao B, et al.

2022-10-05 • BMJ Open

OBJECTIVES
To evaluate the cost-effectiveness of alternative rotavirus vaccines in Niger, using UNIVAC, a proportionate outcomes model.

SETTING
The study leverages globa...

Journal Article

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Research

Isanaka S, Tang K, Berthé F, Grais RF, Pandya A

2022-08-03 • Cost Effectiveness and Resource Allocation

BACKGROUND
In the outpatient management of severe wasting, routine antibiotic therapy is recommended for all children upon admission regardless of whether clinical signs of infection...

Journal Article

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Research

Bliznashka L, Grantz KH, Botton J, Berthé F, Garba S, et al.

2022-07-21 • Maternal and Child Nutrition

This study aimed to quantify the burden of relapse following successful treatment for uncomplicated severe acute malnutrition (SAM) and to identify associated risk factors in rural Niger...

Journal Article

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Commentary

Grais RF, Adamou HO

2014-05-06 • International Health

Journal Article

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Research

Isanaka S, Kodish SR, Berthé F, Alley I, Nackers F, et al.

2017-04-12 • American Journal of Clinical Nutrition

BACKGROUND
Community-based management of severe acute malnutrition (SAM) has been shown to be safe and cost-effective, but program coverage remains low. Treatment models that maintai...

Journal Article

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Commentary

Ager A, Burnham G, Checchi F, Gayer M, Grais RF, et al.

2014-09-12 • Science

Given the growing scale and complexity of responses to humanitarian crises, it is important to develop a stronger evidence base for health interventions in such contexts. Humanitarian cr...

Science Portal

Low-dose yellow fever vaccine in adults in Africa

Effect of mass campaigns with full and fractional doses of pneumococcal conjugate vaccine (Pneumosil) on the reduction of nasopharyngeal pneumococcal carriage in Niger: a three-arm, open-label, cluster-randomised trial

Pregnancy and neonatal outcomes in Eastern Democratic Republic of the Congo: a systematic review

Immunogenicity of an extended dose interval for the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen in adults and children in the Democratic Republic of the Congo

Delivery and safety of a two-dose preventive Ebola virus disease vaccine in pregnant and non-pregnant participants during an outbreak in the Democratic Republic of the Congo

Perceptions, attitudes, and willingness of healthcare and frontline workers to participate in an Ebola vaccine trial in Uganda

Building partnerships and confronting challenges: Implementation of an ebola virus vaccine clinical study during an outbreak in the Democratic Republic of the Congo

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Reflections on participation in a trial on hydroxychloroquine as prevention for COVID-19 among health workers in Niger

Immunogenicity and safety of fractional doses of 17D-213 yellow fever vaccine in children (YEFE): a randomised, double-blind, non-inferiority substudy of a phase 4 trial

A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)–Study protocol

Protection, health seeking, or a laissez-passer: Participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo

Cost-effectiveness of monthly follow-up for the treatment of uncomplicated severe acute malnutrition: An economic evaluation of a randomized controlled trial

Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine (ERVEBO®) in African clinical trial participants by age, sex, and baseline GP-ELISA titer: A post hoc analysis of three Phase 2/3 trials

Impact and cost-effectiveness of rotavirus vaccination in Niger: a modelling study evaluating alternative rotavirus vaccines

Cost-effectiveness of routine versus indicated antibiotic therapy in the management of severe wasting in children

Burden and risk factors for relapse following successful treatment of uncomplicated severe acute malnutrition in young children: Secondary analysis from a randomised trial in Niger

Keeping rotavirus vaccines on the international agenda

Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution

Strengthening the evidence base for health programming in humanitarian crises