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Showing 1 - 20 of 171 Items
Showing 1 - 20 of 171 Items
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Research

Effect of caregiver training on knowledge and confidence of at-home clinical and anthropometric surveillance of children with uncomplicated severe acute malnutrition: analysis of a cross-over cluster randomised trial in Sokoto, Nigeria

Ali NB, Hitchings MD, Berthé F, Aruna P, Shehu I,  et al.
2025-10-01 • BMJ Global Health
2025-10-01 • BMJ Global Health

INTRODUCTION

Patient-centred task-shifting models may be a promising strategy in the community-based management of severe acute malnutrition (SAM) to alleviate ...

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Commentary

Keeping rotavirus vaccines on the international agenda

Grais RF, Adamou HO
2014-05-06 • International Health
2014-05-06 • International Health
Journal Article
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Research
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Commentary

Strengthening the evidence base for health programming in humanitarian crises

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Commentary
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Review

Acceptability of a microbiome-directed food for the management of children with uncomplicated acute malnutrition in Maradi, Niger: Two randomized crossover trials

Rattigan SM, Mbouombouo IN, Abdou Tahirou MA, Mostafa I, Saqeeb KN,  et al.
2025-06-09 • Current Developments in Nutrition
2025-06-09 • Current Developments in Nutrition

BACKGROUND

A novel ready-to-use microbiome-directed food (MDF) has been developed for the management ...

Low-dose yellow fever vaccine in adults in Africa

Kimathi D, Juan-Giner A, Bob NS, Orindi B, Namulwana ML,  et al.
2025-02-20 • New England Journal of Medicine
2025-02-20 • New England Journal of Medicine

BACKGROUND

Yellow fever vaccine is highly effective with a single dose, but vaccine supply is limited. The minimum dose requirements for seroconversion remain u...

Effect of mass campaigns with full and fractional doses of pneumococcal conjugate vaccine (Pneumosil) on the reduction of nasopharyngeal pneumococcal carriage in Niger: a three-arm, open-label, cluster-randomised trial

Coldiron ME, Soumana I, Baudin E, Langendorf C, Mamiafo Tchoula C,  et al.
2025-01-08 • Lancet Infectious Diseases
2025-01-08 • Lancet Infectious Diseases

BACKGROUND

In settings with low pneumococcal conjugate vaccine (PCV) coverage, multi-age cohort mass campaigns could increase population immunity, and fractiona...

Pregnancy and neonatal outcomes in Eastern Democratic Republic of the Congo: a systematic review

Kasonia K, Brindle H, Manno D, Edwards T, Gardais S,  et al.
2024-12-05 • Frontiers in Global Women's Health
2024-12-05 • Frontiers in Global Women's Health

BACKGROUND

Conflict is known to impact maternal and neonatal health in Eastern Democratic Republic of the Congo (DRC), an area of longstanding insecurity. We co...

Immunogenicity of an extended dose interval for the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen in adults and children in the Democratic Republic of the Congo

Choi EM, Kasonia K, Kavunga-Membo H, Mukadi-Bamuleka D, Soumah A,  et al.
2024-07-26 • Vaccines
2024-07-26 • Vaccines

During the 2018–2020 Ebola virus disease outbreak in Democratic Republic of the Congo, a phase 3 trial of the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine (DRC-EB-001) commenced in Goma, wit...

Delivery and safety of a two-dose preventive Ebola virus disease vaccine in pregnant and non-pregnant participants during an outbreak in the Democratic Republic of the Congo

Kavunga-Membo H, Watson-Jones D, Kasonia K, Edwards T, Camacho A,  et al.
2024-07-23 • Vaccines
2024-07-23 • Vaccines

During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first stud...

Perceptions, attitudes, and willingness of healthcare and frontline workers to participate in an Ebola vaccine trial in Uganda

Kimbugwe G, Vatrinet R, Mwanga JA, Kakuru R, Mpeirwe D,  et al.
2024-04-01 • Vaccine
2024-04-01 • Vaccine
BACKGROUND
Understanding the knowledge, perception and attitudes towards Ebola vaccines is an important factor in ensuring future use of these vaccines. A qualitative methods study e...

Building partnerships and confronting challenges: Implementation of an ebola virus vaccine clinical study during an outbreak in the Democratic Republic of the Congo

Bausch DG, Kavunga-Membo H, Grais RF, Imbault N, Roberts N,  et al.
2023-12-31 • Nephrology Dialysis Transplantation
2023-12-31 • Nephrology Dialysis Transplantation

Research, especially clinical trials, during outbreaks often poses enormous challenges, and up until very recent times was often considered almost impossible. However, for diseases su...

Effect of amoxicillin on the gut microbiome of children with severe acute malnutrition in Madarounfa, Niger: a retrospective metagenomic analysis of a placebo-controlled trial

Schwartz DJ, Langdon A, Sun X, Langendorf C, Berthé F,  et al.
2023-10-19 • Lancet Microbe
2023-10-19 • Lancet Microbe
BACKGROUND
Children with severe acute malnutrition are treated with antibiotics as outpatients. We aimed to determine the effect of 7 days of amoxicillin on acute and long-term chang...

Reflections on participation in a trial on hydroxychloroquine as prevention for COVID-19 among health workers in Niger

Kabore Y, Vatrinet R, Guindo O, Moussa SH, Schilling WHK,  et al.
2023-09-06 • American Journal of Tropical Medicine and Hygiene
2023-09-06 • American Journal of Tropical Medicine and Hygiene
In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a rapidly emerging virus causing the coronavirus disease 2019 (COVID-19) pandemic, had no known effective prophylax...

Immunogenicity and safety of fractional doses of 17D-213 yellow fever vaccine in children (YEFE): a randomised, double-blind, non-inferiority substudy of a phase 4 trial

Juan-Giner A, Namulwana ML, Kimathi D, Grantz KH, Fall G,  et al.
2023-04-28 • Lancet Infectious Diseases
2023-04-28 • Lancet Infectious Diseases
BACKGROUND
Current supply shortages constrain yellow fever vaccination activities, particularly outbreak response. Although fractional doses of all WHO-prequalified yellow fever vacc...

A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)–Study protocol

Penfold S, Adegnika AA, Asogun D, Ayodeji O, Azuogu BN,  et al.
2023-03-30 • PLOS One
2023-03-30 • PLOS One
BACKGROUND
Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa and causes 5000 fatalities every year. The true prevalence and i...

Protection, health seeking, or a laissez-passer: Participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo

James M, Kasereka JG, Kasiwa B, Kavunga-Membo H, Kambale K,  et al.
2023-03-15 • Social Science and Medicine
2023-03-15 • Social Science and Medicine
During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu. This prov...

Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution

Isanaka S, Kodish SR, Berthé F, Alley I, Nackers F,  et al.
2017-04-12 • American Journal of Clinical Nutrition
2017-04-12 • American Journal of Clinical Nutrition
BACKGROUND
Community-based management of severe acute malnutrition (SAM) has been shown to be safe and cost-effective, but program coverage remains low. Treatment models that maintai...
Ager A, Burnham G, Checchi F, Gayer M, Grais RF,  et al.
2014-09-12 • Science
2014-09-12 • Science
Given the growing scale and complexity of responses to humanitarian crises, it is important to develop a stronger evidence base for health interventions in such contexts. Humanitarian cr...

Measles outbreak response immunization is context-specific: insight from the recent experience of médecins sans frontières

Minetti A, Bopp C, Fermon F, Francois G, Grais RF,  et al.
2013-11-05 • PLOS Medicine
2013-11-05 • PLOS Medicine
Andrea Minetti and colleagues compare measles outbreak responses from the Democratic Republic of the Congo and Malawi and argue that outbreak response strategies should be tailored to lo...

Development of a patient rated scale for mental health global state for use during humanitarian interventions

Llosa AE, Martinez-Viciana C, Carreño C, Evangelidou S, Casas G,  et al.
2020-09-18 • International Journal of Methods in Psychiatric Research
2020-09-18 • International Journal of Methods in Psychiatric Research
OBJECTIVE
We present the results of a cross-cultural validation of the Mental Health Global State (MHGS) scale for adults and adolescents (<14 years old).

METHODS
We per...

Urgently seeking efficiency and sustainability of clinical trials in global health

Park JS, Grais RF, Taljaard M, Nakimuli-Mpungu E, Jehan F,  et al.
2021-05-01 • Lancet Global Health
2021-05-01 • Lancet Global Health
This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on c...