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Euro Surveill. 2014 October 9; Volume 19 (Issue 40); 20924.
Fitzpatrick G, Vogt F, Gbabai O, Black B, Santantonio M, et al.
Euro Surveill. 2014 October 9; Volume 19 (Issue 40); 20924.
Case management centres (CMCs) are part of the outbreak control plan for Ebola virus disease (EVD). A CMC in Sierra Leone had 33% (138/419) of primary admissions discharged as EVD negative (not a case). Fifteen of these were readmitted within 21 days, nine of which were EVD positive. All readmissions had contact with an Ebola case in the community in the previous 21 days indicating that the infection was likely acquired outside the CMC.
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Trop Med Int Health. 2015 January 7; Volume 20 (Issue 4); DOI:10.1111/tmi.12454
Dallatomasinas S, Crestani R, Squire JS, Declerck H, Caleo GNC, et al.
Trop Med Int Health. 2015 January 7; Volume 20 (Issue 4); DOI:10.1111/tmi.12454
To describe Ebola cases in the district Ebola Management Centre of in Kailahun, a remote rural district of Sierra Leone, in terms of geographic origin, patient and hospitalization characteristics, treatment outcomes and time from symptom onset to admission.
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J Infect Dis. 2015 May 22; Volume 212 (Issue 11); DOI:10.1093/infdis/jiv304
Fitzpatrick G, Vogt F, Gbabai O, Decroo T, Keane M, et al.
J Infect Dis. 2015 May 22; Volume 212 (Issue 11); DOI:10.1093/infdis/jiv304
This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.
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Emerg Med (Los Angel). 2015 October 13; Volume 05 (Issue 06); DOI:10.4172/2165-7548.1000285
Hugo M, Declerck H, Fitzpatrick G, Severy N, Gbabai O, et al.
Emerg Med (Los Angel). 2015 October 13; Volume 05 (Issue 06); DOI:10.4172/2165-7548.1000285
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PLoS Negl Trop Dis. 2016 March 9; Volume 10 (Issue 3); DOI:10.1371/journal.pntd.0004498
Lokuge K, Caleo GNC, Greig J, Duncombe J, McWilliam N, et al.
PLoS Negl Trop Dis. 2016 March 9; Volume 10 (Issue 3); DOI:10.1371/journal.pntd.0004498
The scale and geographical distribution of the current outbreak in West Africa raised doubts as to the effectiveness of established methods of control. Ebola Virus Disease (EVD) was first detected in Sierra Leone in May 2014 in Kailahun district. Despite high case numbers elsewhere in the country, transmission was eliminated in the district by December 2014. We describe interventions underpinning successful EVD control in Kailahun and implications for EVD control in other areas.
Journal Article > ResearchFull Text
Euro Surveill. 2014 October 9
Fitzpatrick G, Vogt F, Gbabai O, Black B, Santantonio M, et al.
Euro Surveill. 2014 October 9