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Showing 1 - 20 of 33 Items
Showing 1 - 20 of 33 Items
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Journal Article
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Research

Changes over time in the proportion of advanced HIV disease in two high HIV prevalence settings in Ndhiwa (Kenya) and Eshowe (South Africa)

Chihana M, Conan N, Ohler L, Huerga H, Wanjala S,  et al.
2024-06-17 • Journal of the International Association of Providers of AIDS Care
2024-06-17 • Journal of the International Association of Providers of AIDS Care
BACKGROUND
The burden of advanced HIV disease remains a significant concern in sub-Saharan Africa. In 2015, the World Health Organization released recommendations to treat all people...
Journal Article
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Research

Adolescents and young adults are the most undiagnosed of HIV and virally unsuppressed in Eastern and Southern Africa: Pooled analyses from five population-based surveys

Huerga H, Farhat JB, Maman D, Conan N, Van Cutsem G,  et al.
2023-12-22 • PLOS Global Public Health
2023-12-22 • PLOS Global Public Health
Age and gender disparities within the HIV cascade of care are critical to focus interventions efficiently. We assessed gender-age groups at the highest probability of unfavorable outcome...
Journal Article
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Research

Comparison of methods to correct survival estimates and survival regression analysis on a large HIV African cohort

Henriques J, Pujades M, McGuire M, Szumilin E, Iwaz J,  et al.
2012-02-23 • PLOS One
2012-02-23 • PLOS One
OBJECTIVE
The evaluation of HIV treatment programs is generally based on an estimation of survival among patients receiving antiretroviral treatment (ART). In large HIV programs, los...
Journal Article
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Research

Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya

Nackers F, Huerga H, Espie E, Aloo AO, Bastard M,  et al.
2012-03-12 • PLOS One
2012-03-12 • PLOS One
Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned. ...
Journal Article
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Research

Potential Impact of Multiple Interventions on HIV Incidence in a Hyperendemic Region in Western Kenya: a Modelling Study

Blaizot S, Maman D, Riche B, Mukui I, Kirubi B,  et al.
2016-04-29 • BMC Infectious Diseases
2016-04-29 • BMC Infectious Diseases
Multiple prevention interventions, including early antiretroviral therapy initiation, may reduce HIV incidence in hyperendemic settings. Our aim was to predict the short-term impact of v...
Journal Article
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Research

Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marche Hospital, Bunia, Democratic Republic of Congo

Mueller YK, Bastard M, Ehounou G, Itama J, Quere M,  et al.
2012-10-11 • Tropical Medicine and International Health
2012-10-11 • Tropical Medicine and International Health
Objective  To assess the effectiveness of blood transfusions in a hospital of north-eastern Democratic Republic of the Congo. Methods  Prospective study of children admitted for severe a...
Journal Article
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Research

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria

Chotsiri P, Denoeud-Ndam L, Baudin E, Guindo O, Diawara H,  et al.
2019-06-01 • Clinical Pharmacology & Therapeutics
2019-06-01 • Clinical Pharmacology & Therapeutics
Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub‐Saharan African children and may affect the pharmacology of antimalarial drugs....
Journal Article
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Research

Women experience a better long-term immune recovery and a better survival on HAART in Lao People's Democratic Republic

Bastard M, Soulinphumy K, Phimmasone P, Saadani A, Ciaffi L,  et al.
2013-01-22 • BMC Infectious Diseases
2013-01-22 • BMC Infectious Diseases
BACKGROUND
In April 2003, Médecins Sans Frontières launched an HIV/AIDS programme to provide free HAART to HIV-infected patients in Laos. Although HIV prevalence is estimated as low ...
Journal Article
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Research

Closer to 90-90-90. The Cascade of Care After 10 Years of ART Scale-Up in Rural Malawi: a Population Study

Maman D, Chilima B, Masiku C, Ayouba A, Masson S,  et al.
2016-02-15 • Journal of the International AIDS Society
2016-02-15 • Journal of the International AIDS Society
The antiretroviral therapy (ART) programme supported by Médecins Sans Frontières in the rural Malawian district of Chiradzulu was one of the first in sub-Saharan Africa to scale up ART d...
Journal Article
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Research

Inhaled nitric oxide as an adjunctive treatment for cerebral malaria in children: a phase II randomized open-label clinical trial

Mwanga-Amumpaire J, Carroll R, Baudin E, Kemigisha E, Nampijja D,  et al.
2015-07-24 • Open Forum Infectious Diseases
2015-07-24 • Open Forum Infectious Diseases
Abstract
Background.  Children with cerebral malaria (CM) have high rates of mortality and neurologic sequelae. Nitric oxide (NO) meta...
Journal Article
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Research

Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa

Egger M, Sidle J, Weigel R, Geng EH, Fox MP,  et al.
2011-01-01 • PLOS Medicine
2011-01-01 • PLOS Medicine
The World Health Organization estimates that in sub-Saharan Africa about 4 million HIV-infected patients had started antiretroviral therapy (ART) by the end of 2008. Loss of patients to ...
Journal Article
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Research

Heterogeneous decrease in malaria prevalence in children over a six-year period in south-western Uganda

De Beaudrap P, Nabasumba C, Grandesso F, Turyakira E, Schramm B,  et al.
2011-05-18 • Malaria Journal
2011-05-18 • Malaria Journal
BACKGROUND
Malaria is a major public health problem, especially for children. However, recent reports suggest a decline in the malaria burden. The aim of this study was to assess the...
Journal Article
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Research

Estimating HIV incidence using a cross-sectional survey: comparison of three approaches in a hyperendemic setting, Ndhiwa sub-county, Kenya, 2012

Blaizot S, Kim AA, Zeh C, Riche B, Maman D,  et al.
2016-11-08 • AIDS Research and Human Retroviruses
2016-11-08 • AIDS Research and Human Retroviruses
OBJECTIVES
Estimating HIV incidence is critical for identifying groups at risk for HIV infection, planning and targeting interventions, and evaluating these interventions over time. ...
Journal Article
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Research

Toxicity associated with stavudine dose reduction from 40 to 30 mg in first-line antiretroviral therapy

Pujades-Rodriguez M, Dantony E, Pinoges LLP, Ecochard R, Etard JF,  et al.
2011-11-21 • PLOS One
2011-11-21 • PLOS One
BACKGROUND
To compare the incidence and timing of toxicity associated with the use of a reduced dose of stavudine from 40 to 30 mg in first-line antiretroviral therapy (ART) for HIV ...
Journal Article
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Research

Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger

Grandesso F, Guindo O, Woi-Messe LC, Makarimi R, Traore A,  et al.
2018-01-25 • Malaria Journal
2018-01-25 • Malaria Journal
BACKGROUND
Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland S...
Journal Article
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Research

An alternative classification to mixture modeling for longitudinal counts or binary measures

Subtil F, Boussari O, Bastard M, Etard JF, Ecochard R,  et al.
2014-09-01 • Statistical Methods in Medical Research
2014-09-01 • Statistical Methods in Medical Research
Classifying patients according to longitudinal measures, or trajectory classification, has become frequent in clinical research. The k-means algorithm is increasingly used for this task ...
Journal Article
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Research

Who Needs to Be Targeted for HIV Testing and Treatment in KwaZulu-Natal? Results From a Population-Based Survey

Huerga H, van Cutsem G, Ben Farhat J, Reid M, Bouhenia M,  et al.
2016-12-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
2016-12-01 • Journal of Acquired Immune Deficiency Syndromes (1999)
Identifying gaps in HIV testing and treatment is essential to design specific strategies targeting those not accessing HIV services. We assessed the prevalence and factors associated wit...
Journal Article
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Research

Estimation and short-term prediction of the course of the HIV epidemic using demographic and health survey methodology-like data

Blaizot S, Riche B, Maman D, Mukui I, Kirubi B,  et al.
2015-06-19 • PLOS One
2015-06-19 • PLOS One
BACKGROUND
Mathematical models have played important roles in the understanding of epidemics and in the study of the impacts of various behavioral or medical measures. However, model...
Journal Article
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Research

Response to antiretroviral therapy: improved survival associated with CD4 above 500 cells/μl

Maman D, Pujades-Rodriguez M, Nicholas S, McGuire M, Szumilin E,  et al.
2012-07-17 • AIDS
2012-07-17 • AIDS
OBJECTIVE
We investigated the association between immune response and mortality in four HIV African programs supported by Médecins Sans Frontières.

DESIGN
Multicentric r...
Journal Article
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Research

Combined Interventions to Reduce HIV Incidence in KwaZulu-Natal: A Modelling Study

Blaizot S, Huerga H, Riche B, Ellman T, Shroufi A,  et al.
2017-07-26 • BMC Infectious Diseases
2017-07-26 • BMC Infectious Diseases
Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings. Our aim was to assess the potential...