Search Results | MSF Science Portal

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Research

Fenner L, Atkinson A, Boulle AM, Fox MP, Prozesky HW, et al.

2017-06-23 • Journal of the International AIDS Society

Chronic immune activation due to ongoing HIV replication may lead to impaired immune responses against opportunistic infections such as tuberculosis (TB). We studied the role of HIV repl...

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Research

Estill J, Egger M, Johnson LF, Gsponer T, Wandeler G, et al.

2013-02-28 • PLOS One

OBJECTIVES
Mortality in patients starting antiretroviral therapy (ART) is higher in Malawi and Zambia than in South Africa. We examined whether different monitoring of ART (viral loa...

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Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, et al.

2010-09-10 • AIDS

OBJECTIVE: Little is known about the temporal impact of the rapid scale-up of large antiretroviral therapy (ART) services on programme outcomes. We describe patient outcomes [mortality, ...

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Research

Gsponer T, Weigel R, Davies MA, Bolton C, Moultrie H, et al.

2012-09-17 • Pediatrics

BACKGROUND
Poor growth is an indication for antiretroviral therapy (ART) and a criterion for treatment failure. We examined variability in growth response to ART in 12 programs in Ma...

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Ballif M, Zurcher K, Reid SE, Boulle AM, Fox MP, et al.

2018-01-11 • BMJ Open

Seasonal variations in tuberculosis diagnoses have been attributed to seasonal climatic changes and indoor crowding during colder winter months. We investigated trends in pulmonary tuber...

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Lawn SD, Campbell L, Kaplan R, Boulle AM, Cornell M, et al.

2011-06-01 • Journal of Acquired Immune Deficiency Syndromes (1999)

We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per micro...

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Boulle AM, Schomaker M, May MT, Hogg RS, Shepherd B, et al.

2014-09-09 • PLOS Medicine

BACKGROUND
High early mortality in patients with HIV-1 starting antiretroviral therapy (ART) in sub-Saharan Africa, compared to Europe and North America, is well documented. Longer-t...

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Research

Hoffman CJ, Schomaker M, Fox MP, Mutevedzi, Giddy J, et al.

2013-01-22 • Journal of Acquired Immune Deficiency Syndromes (1999)

In many resource-limited settings monitoring of combination antiretroviral therapy (cART) is based on the current CD4 count, with limited access to HIV RNA tests or laboratory diagnostic...

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Research

Fenner L, Brinkhof MW, Keiser O, Weigel R, Cornell M, et al.

2010-08-01 • Journal of Acquired Immune Deficiency Syndromes (1999)

BACKGROUND: Many HIV-infected children in Southern Africa have been started on antiretroviral therapy (ART), but loss to follow up (LTFU) can be substantial. We analyzed mortality in chi...

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Keiser O, Tweya H, Boulle AM, Braitstein P, Schechter M, et al.

2009-09-10 • AIDS

BACKGROUND
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring ...

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Fenner L, Ballif M, Graber C, Nhandu V, Dusingize JC, et al.

2013-10-17 • PLOS One

In resource-constrained settings, tuberculosis (TB) is a common opportunistic infection and cause of death in HIV-infected persons. TB may be present at the start of antiretroviral thera...

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Schomaker M, Davies A, Malateste K, Renner L, Sawry S, et al.

2015-10-16 • Epidemiology

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Research

Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q, et al.

2016-10-31 • Nature Genetics

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collectio...

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Egger M, Sidle J, Weigel R, Geng EH, Fox MP, et al.

2011-01-01 • PLOS Medicine

The World Health Organization estimates that in sub-Saharan Africa about 4 million HIV-infected patients had started antiretroviral therapy (ART) by the end of 2008. Loss of patients to ...

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Johnson LF, Mossong J, Dorrington R, Schomaker M, Hoffman CJ, et al.

2013-04-09 • PLOS Medicine

Few estimates exist of the life expectancy of HIV-positive adults receiving antiretroviral treatment (ART) in low- and middle-income countries. We aimed to estimate the life expectancy o...

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Koller M, Fatti G, Chi BH, Keiser O, Hoffman CJ, et al.

2015-07-07 • Journal of Acquired Immune Deficiency Syndromes (1999)

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Research

Wandeler G, Gsponer T, Mulenga L, Garone DB, Wood R, et al.

2013-09-01 • AIDS

OBJECTIVES
Zidovudine (ZDV) is recommended for first-line antiretroviral therapy (ART) in resource-limited settings. ZDV may, however, lead to anemia and impaired immunological respo...

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Research

Cornell M, Schomaker M, Garone DB, Giddy J, Hoffmann CJ, et al.

2012-09-04 • PLOS Medicine

Background: Increased mortality among men on antiretroviral therapy (ART) has been documented but remains poorly understood. We examined the magnitude of and risk factors for g...

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Research

Salazar-Vizcaya L, Keiser O, Technau KG, Davies MA, Haas AD, et al.

2014-10-23 • AIDS

OBJECTIVES
Many paediatric antiretroviral therapy (ART) programmes in Southern Africa rely on CD4⁺ to monitor ART. We assessed the benefit of replacing CD4⁺ by viral load monitoring....

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Research

Davies MA, Boulle AM, Technau KG, Eley B, Moultrie H, et al.

2012-09-01 • Tropical Medicine and International Health

OBJECTIVES
To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral ...

Science Portal

HIV Viral Load as an Independent Risk Factor for Tuberculosis in South Africa: Collaborative Analysis of Cohort Studies

Monitoring of antiretroviral therapy and mortality in HIV programmes in Malawi, South Africa and Zambia: mathematical modelling study

Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007

Variability of growth in children starting antiretroviral treatment in Southern Africa

Seasonal variations in tuberculosis diagnosis among HIV-positive individuals in Southern Africa: analysis of cohort studies at antiretroviral treatment programmes

Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa

Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies

CD4 count slope and mortality in HIV-infected patients on antiretroviral therapy: multicohort analysis from South Africa

Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring

Tuberculosis in antiretroviral treatment programs in lower income countries: availability and use of diagnostics and screening

Growth and mortality outcomes for different antiretroviral therapy initiation criteria in children aged 1-5 years: a causal modelling analysis

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa

Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies

Risk charts to guide targeted HIV-1 viral load monitoring of ART: development and validation in patients from resource-limited settings

Zidovudine impairs immunological recovery on first-line antiretroviral therapy: collaborative analysis of cohort studies in southern Africa

Gender differences in survival among adult patients starting antiretorivral therapy in South Africa: a multicentre cohort study

Viral load versus CD4⁺ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure