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Copyright © Médecins Sans Frontières
v2.1.5209.produseast1
Showing 1 - 8 of 8 Items
Showing 1 - 8 of 8 Items
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Journal Article
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Research

Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis

Zwang J, Olliaro PL, Barennes H, Bonnet MMB, Brasseur P,  et al.
2009-08-23 • Malaria Journal
2009-08-23 • Malaria Journal
BACKGROUND: Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapy (ACT). It was necessary to evaluate the efficacy of...
Journal Article
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Research

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q,  et al.
2020-02-25 • BMC Medicine
2020-02-25 • BMC Medicine
BACKGROUND
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquin...
Journal Article
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Research

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C,  et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Journal Article
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Research

Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger

Grandesso F, Guindo O, Woi-Messe LC, Makarimi R, Traore A,  et al.
2018-01-25 • Malaria Journal
2018-01-25 • Malaria Journal
BACKGROUND
Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland S...
Journal Article
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Research

Seasonal malaria chemoprevention with sulphadoxine-pyrimethamine and amodiaquine selects pfdhfr-dhps quintuple mutant genotype in Mali

Maiga H, Lasry E, Diarra M, Sagara I, Bamadio A,  et al.
2016-09-23 • PLOS One
2016-09-23 • PLOS One
BACKGROUND
Seasonal malaria chemoprevention (SMC) with sulphadoxine-pyrimethamine (SP) plus amodiaquine (AQ) is being scaled up in Sahelian countries of West Africa. However, the pot...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...
Protocol
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Research Protocol

A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study

Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F,  et al.
2015-06-12 • BMC Infectious Diseases
2015-06-12 • BMC Infectious Diseases
Malnutrition and malaria frequently coexist in sub-Saharan African countries. Studies on efficacy of antimalarial treatments usually follow the WHO standardized protocol in which severel...
Journal Article
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Research

Two-year scale-up of seasonal malaria chemoprevention reduced malaria morbidity among children in the health district of Koutiala, Mali

Maiga H, Gaudart J, Sagara I, Diarra M, Bamadio A,  et al.
2020-09-11 • International Journal of Environmental Research and Public Health
2020-09-11 • International Journal of Environmental Research and Public Health
BACKGROUND
Previous controlled studies demonstrated seasonal malaria chemoprevention (SMC) reduces malaria morbidity by >80% in children aged 3-59 months. Here, we assessed malaria m...