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v2.1.5153.produseast1
Showing 1 - 10 of 10 Items
Showing 1 - 10 of 10 Items
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Journal Article
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Research

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Schilling WHK, Mukaka M, Callery JJ, Llewelyn MJ, Cruz CV,  et al.
2024-09-12 • PLOS Medicine
2024-09-12 • PLOS Medicine

BACKGROUND

Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety an...

Conference Material
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Slide Presentation

Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review

Wilson JM, Chowdhury F, Hassan S, Harriss E, Alves F,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Abstract

Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review

Wilson JM, Chowdhury F, Hassan S, Harriss E, Alves F,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
Visceral leishmaniasis (VL) is a neglected tropical disease prevalent in populations affected by poverty, war, and famine. Without effective treatment, death is the norm...
Journal Article
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Review

Blood transfusion in the care of patients with visceral leishmaniasis: a review of practices in therapeutic efficacy studies

Dahal P, Singh-Phulgenda S, Wilson JM, Cota G, Ritmeijer K,  et al.
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2024-05-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Blood transfusion remains an important aspect of patient management in visceral leishmaniasis (VL). However, transfusion triggers considered are poorly understood. This review summarises...
Journal Article
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Protocol

Haematological dynamics following treatment of visceral leishmaniasis: a protocol for systematic review and individual participant data (IPD) meta-analysis

Munir A, Dahal P, Kumar R, Singh-Phulgenda S, Siddiqui NA,  et al.
2023-12-14 • BMJ Open
2023-12-14 • BMJ Open
INTRODUCTION
Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30,000 new cases occurring annually. Despite anaemia being a common haematological manifestation of ...
Journal Article
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Protocol

Host, parasite and drug determinants of clinical outcomes following treatment of visceral leishmaniasis: a protocol for individual participant data meta-analysis

Kumar R, Dahal P, Singh-Phulgenda S, Siddiqui NA, Munir A,  et al.
2023-10-28 • BMJ Open
2023-10-28 • BMJ Open
INTRODUCTION
Visceral leishmaniasis (VL) is a parasitic disease with an estimated 30 000 new cases occurring annually. There is an observed variation in the efficacy of the current f...
Journal Article
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Research

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q,  et al.
2020-02-25 • BMC Medicine
2020-02-25 • BMC Medicine
BACKGROUND
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquin...
Journal Article
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Review

Visceral leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

Dahal P, Singh-Phulgenda S, Maguire BJ, Harriss E, Ritmeijer KKD,  et al.
2021-08-10 • PLOS Neglected Tropical Diseases
2021-08-10 • PLOS Neglected Tropical Diseases
BACKGROUND
Reports on the occurrence and outcome of Visceral Leishmaniasis (VL) in pregnant women is rare in published literature. The occurrence of VL in pregnancy is not systematic...
Journal Article
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Research

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C,  et al.
2014-07-21 • American Journal of Tropical Medicine and Hygiene
2014-07-21 • American Journal of Tropical Medicine and Hygiene
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroq...
Journal Article
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Research

Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis

WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal P, Simpson JA, Abdulla S, Achan J,  et al.
2019-07-05 • Malaria Journal
2019-07-05 • Malaria Journal
BACKGROUND
Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potenti...