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Commentary

Antiretroviral treatment uptake and attrition among HIV-positive patients with tuberculosis in Kibera, Kenya

Tayler-Smith K, Zachariah R, Manzi M, Kizito W, Vandenbulcke A,  et al.
2011-08-10 • Tropical Medicine and International Health
2011-08-10 • Tropical Medicine and International Health
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Adherence to self-administered tuberculosis treatment in a high HIV-prevalence setting: a cross-sectional survey in Homa Bay, Kenya

Nackers F, Huerga H, Espie E, Aloo AO, Bastard M,  et al.
2012-03-12 • PLOS One
2012-03-12 • PLOS One
Good adherence to treatment is crucial to control tuberculosis (TB). Efficiency and feasibility of directly observed therapy (DOT) under routine program conditions have been questioned. ...

Is introducing rapid culture in the diagnostic algorithm of smear-negative tuberculosis cost-effective?

Yakhelef N, Audibert M, Varaine FFV, Chakaya JM, Sitienei J,  et al.
2014-05-14 • International Journal of Tuberculosis and Lung Disease
2014-05-14 • International Journal of Tuberculosis and Lung Disease
SETTING
In 2007, the World Health Organization recommended introducing rapid Mycobacterium tuberculosis culture into the diagnostic algorithm of smear-negative pulmonary tuberculosis...

The structured operational research and training initiative for strengthening health systems to tackle antimicrobial resistance and improve public health in low-and-middle income countries

Zachariah R, Stewart AG, Chakaya JM, Teck R, Khogali MA,  et al.
2022-04-11 • International Journal of Environmental Research and Public Health
2022-04-11 • International Journal of Environmental Research and Public Health

Cost and affordability of non-communicable disease screening, diagnosis and treatment in Kenya: Patient payments in the private and public sectors

Subramanian S, Gakunga R, Kibachio J, Gathecha G, Edwards P,  et al.
2018-01-05 • PLOS One
2018-01-05 • PLOS One
The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quant...

Drug-Resistant Tuberculosis--Current dilemmas, unanswered questions, challenges, and priority needs

Zumla A, Abubakar I, Raviglione M, Hoelscher M, Ditui L,  et al.
2012-04-03 • Journal of Infectious Diseases
2012-04-03 • Journal of Infectious Diseases
Tuberculosis was declared a global emergency by the World Health Organization (WHO) in 1993. Following the declaration and the promotion in 1995 of directly observed treatment short cour...

MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Migliori GB, Tiberi S, Zumla A, Petersen E, Chakaya JM,  et al.
2020-02-01 • International Journal of Infectious Diseases
2020-02-01 • International Journal of Infectious Diseases
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at provid...

Building leadership capacity and future leaders in operational research in low-income countries: why and how?

Zachariah R, Reid AJ, Srinath S, Chakaya JM, Legins K,  et al.
2011-11-01 • International Journal of Tuberculosis and Lung Disease
2011-11-01 • International Journal of Tuberculosis and Lung Disease
Very limited operational research (OR) emerges from programme settings in low-income countries where the greatest burden of disease lies. The price paid for this void includes a lack of ...

Clinical standards for the assessment, management and rehabilitation of post-TB lung disease

Migliori GB, Marx FM, Ambrosino N, Zampogna E, Schaaf HS,  et al.
2021-10-01 • International Journal of Tuberculosis and Lung Disease
2021-10-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the...

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities

McNerney R, Maeurer M, Abubakar I, Marais BJ, McHugh TD,  et al.
2012-04-10 • Journal of Infectious Diseases
2012-04-10 • Journal of Infectious Diseases
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to...

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

Lienhardt C, Lonnroth K, Menzies D, Balasegaram M, Chakaya JM,  et al.
2016-03-02 • PLOS Medicine
2016-03-02 • PLOS Medicine
Christian Lienhardt and colleagues describe the research efforts needed to end the global tuberculosis epidemic by 2035.

Towards host-directed therapies for tuberculosis

Zumla A, Chakaya JM, Hoelscher M, Ntoumi F, Rustomjee R,  et al.
2015-07-17 • Nature Reviews Drug Discovery
2015-07-17 • Nature Reviews Drug Discovery

Performance of the 2007 WHO Algorithm to diagnose Smear-negative Pulmonary Tuberculosis in a HIV prevalent setting

Huerga H, Varaine FFV, Okwaro E, Bastard M, Ardizzoni E,  et al.
2012-12-19 • PLOS One
2012-12-19 • PLOS One
BACKGROUND
The 2007 WHO algorithm for diagnosis of smear-negative pulmonary tuberculosis (PTB) including Mycobacterium tuberculosis (MTB) culture was evaluated in a HIV prevalent are...

Tuberculosis treatment outcomes among hospital workers at a public teaching and national referral hospital in Kenya

Wahome E, Makori L, Gikera M, Chakaya JM, Edginton ME,  et al.
2013-12-21 • Public Health Action
2013-12-21 • Public Health Action
SETTING
Kenyatta National Hospital (KNH), Nairobi, Ken-ya, a large referral and teaching hospital.

OBJECTIVE
1) To document tuberculosis (TB) case notification rates and...

Is operational research delivering the goods? The journey to success in low-income countries

Zachariah R, Ford NP, Maher D, Bissell K, Van der Bergh R,  et al.
2012-02-09 • Lancet Infectious Diseases
2012-02-09 • Lancet Infectious Diseases
Operational research in low-income countries has a key role in filling the gap between what we know from research and what we do with that knowledge-the so-called know-do gap, or impleme...