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Showing 1 - 18 of 18 Items
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Research

Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis

Olbrich L, Larsson L, Dunbar R, Dodd PJ, Palmer M,  et al.
2025-11-18 • PLOS Medicine
2025-11-18 • PLOS Medicine

INTRODUCTION

In 2023, almost 200,000 children under 15 years died from tuberculosis, most without appropriate treatment. Treatment decision algorithms (TDAs), d...

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External quality assurance of chest X-ray interpretation to strengthen diagnosis of childhood TB

Melingui B, 
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Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol

Olbrich L, Larsson L, Dodd P, Palmer M, Nguyen MHTN,  et al.
2025-09-17 • BMJ Open
2025-09-17 • BMJ Open

INTRODUCTION

In 2022, the WHO conditionally recommended the use of treatment decision algorithms (TDAs) for treatment decision-making in children <10 years with...

Implementation of digital chest radiography for childhood tuberculosis diagnosis at district hospital level in six high tuberculosis burden and resources limited countries

Melingui BF, Basant J, Taguebue Jv, Massom DM, Leroy Terquem E,  et al.
2024-11-03 • Journal of Tropical Medicine
2024-11-03 • Journal of Tropical Medicine

OBJECTIVES

Chest x‐ray (CXR) plays an important role in childhood tuberculosis (TB) diagnosis, but access to quality CXR remains a major challenge in resource‐l...

Leroy-Terquem E, 
Taguebue J, 
Eap T, 
Borand L, 
et al.
2024-10-01 • IJTLD OPEN
2024-10-01 • IJTLD OPEN

Cost-effectiveness and budget impact of decentralising childhood tuberculosis diagnosis in six high tuberculosis incidence countries: a mathematical modelling study

d’Elbée M, Harker M, Mafirakureva N, Nanfuka M, Nguyet MHTN,  et al.
2024-03-21 • eClinicalMedicine
2024-03-21 • eClinicalMedicine

Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study

Wobudeya E, Nanfuka M, Ton Nu Nguyet MH, Taguebue JV, Moh R,  et al.
2024-03-21 • ACG Case Reports Journal
2024-03-21 • ACG Case Reports Journal
BACKGROUND
Childhood tuberculosis (TB) remains underdiagnosed largely because of limited awareness and poor access to all or any of specimen collection, molecular testing, clinical e...

Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB

Melingui BF, Leroy-Terquem E, Palmer M, Taguebue JV, Wachinou AP,  et al.
2024-02-01 • IJTLD OPEN
2024-02-01 • IJTLD OPEN
BACKGROUND
Chest X-ray (CXR) interpretation is challenging for the diagnosis of paediatric TB. We assessed the performance of a three half-day CXR training module for healthcare work...

Natural killer repertoire restoration in TB/HIV co-infected individuals experienced an immune reconstitution syndrome (CAMELIA Trial, ANRS 12153)

Pean P, Madec Y, Nerrienet E, Borand L, Laureillard D,  et al.
2023-10-13 • Pathogens
2023-10-13 • Pathogens
IRIS is a common complication in HIV-infected patients treated for tuberculosis (TB) and cART. Our aim was to evaluate NK cell reconstitution in HIV-infected patients with TB-IRIS compar...

Acceptability of decentralizing childhood tuberculosis diagnosis in low-income countries with high tuberculosis incidence: Experiences and perceptions from health care workers in Sub-Saharan Africa and South-East Asia

Joshi B, De Lima YV, Massom DM, Kaing S, Banga MF,  et al.
2023-10-11 • PLOS Global Public Health
2023-10-11 • PLOS Global Public Health
Decentralizing childhood tuberculosis services, including diagnosis, is now recommended by the WHO and could contribute to increasing tuberculosis detection in high burden countries. How...

High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV

Bonnet MMB, Gabillard D, Domoua SK, Muzoora C, Messou E,  et al.
2023-03-08 • Clinical Infectious Diseases
2023-03-08 • Clinical Infectious Diseases
BACKGROUND
In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the perf...

Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Marcy O, Wobudeya E, Font H, Vessière A, Chabala C,  et al.
2023-03-01 • Lancet Infectious Diseases
2023-03-01 • Lancet Infectious Diseases
BACKGROUND
Tuberculosis diagnosis might be delayed or missed in children with severe pneumonia because this diagnosis is usually only considered in cases of prolonged symptoms or ant...

Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome after early initiation of antiretroviral therapy in a randomized clinical trial

Laureillard D, Marcy O, Madec Y, Chea S, Chan S,  et al.
2013-10-23 • AIDS
2013-10-23 • AIDS
To analyze cases of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in the CAMbodian Early versus Late Introduction of Antiretrovirals (CAMELIA)...

Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis

Blanc FX, Sok T, Laureillard D, Borand L, Rekacewicz C,  et al.
2011-10-20 • New England Journal of Medicine
2011-10-20 • New England Journal of Medicine
Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation...

Causes and determinants of mortality in HIV-infected adults with tuberculosis: an analysis from the CAMELIA ANRS 1295-CIPRA KH001 randomized trial

Marcy O, Laureillard D, Madec Y, Chan S, Mayaud C,  et al.
2014-08-01 • Clinical Infectious Diseases
2014-08-01 • Clinical Infectious Diseases
Shortening the interval between antituberculosis treatment onset and initiation of antiretroviral therapy (ART) reduces mortality in severely immunocompromised human immunodeficiency vir...

Systematic or test-guided treatment for tuberculosis in HIV-infected adults

Blanc FX, Badje AD, Bonnet MMB, Gabillard D, Messou E,  et al.
2020-06-18 • New England Journal of Medicine
2020-06-18 • New England Journal of Medicine
BACKGROUND
In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already seve...

Knowledge, attitudes and practices on childhood TB among healthcare workers

Joshi B, Font H, Wobudeya E, Nanfuka M, Kobusingye A,  et al.
2022-03-01 • International Journal of Tuberculosis and Lung Disease
2022-03-01 • International Journal of Tuberculosis and Lung Disease
BACKGROUND
Increasing childhood TB case detection requires the deployment of diagnostic services at peripheral healthcare level. Capacity and readiness of healthcare workers (HCWs) a...

Plasma concentrations, efficacy and safety of efavirenz in HIV-infected adults treated for tuberculosis in Cambodia (ANRS 1295-CIPRA KH001 CAMELIA trial)

Borand L, Madec Y, Laureillard D, Chou M, Marcy O,  et al.
2014-03-07 • PLOS One
2014-03-07 • PLOS One
OBJECTIVE
To assess efavirenz plasma concentrations and their association with treatment efficacy and tolerance of efavirenz 600 mg daily in HIV-tuberculosis co-infected patients.

High Activation of γδ T Cells and the γδ2 T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK.

Pean P, Nouhin J, Ratana M, Madec Y, Borand L,  et al.
2019-08-27 • Frontiers in Immunology
2019-08-27 • Frontiers in Immunology
Background: Human Immunodeficiency Virus 1 (HIV-1) and Mycobacterium Tuberculosis (Mtb) co-infected patients are commonly at risk of immune reconstitution inflammatory syndrome (IRIS) wh...