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Showing 1 - 17 of 17 Items
Showing 1 - 17 of 17 Items
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Journal Article
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Research

Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo

Brindle HE, Tetsa-Tata D, Edwards T, Choi EML, Kasonia K,  et al.
2025-05-02 • PLOS Global Public Health
2025-05-02 • PLOS Global Public Health

Clinical trials in settings with intermittent or non-existent internet and power connectivity, for example ...

Journal Article
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Research

Pregnancy and neonatal outcomes in Eastern Democratic Republic of the Congo: a systematic review

Kasonia K, Brindle H, Manno D, Edwards T, Gardais S,  et al.
2024-12-05 • Frontiers in Global Women's Health
2024-12-05 • Frontiers in Global Women's Health

BACKGROUND

Conflict is known to impact maternal and neonatal health in Eastern Democratic Republic of the Congo (DRC), an area of longstanding insecurity. We co...

Journal Article
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Research

Immunogenicity of an extended dose interval for the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen in adults and children in the Democratic Republic of the Congo

Choi EM, Kasonia K, Kavunga-Membo H, Mukadi-Bamuleka D, Soumah A,  et al.
2024-07-26 • Vaccines
2024-07-26 • Vaccines

During the 2018–2020 Ebola virus disease outbreak in Democratic Republic of the Congo, a phase 3 trial of the Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine (DRC-EB-001) commenced in Goma, wit...

Journal Article
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Research

Delivery and safety of a two-dose preventive Ebola virus disease vaccine in pregnant and non-pregnant participants during an outbreak in the Democratic Republic of the Congo

Kavunga-Membo H, Watson-Jones D, Kasonia K, Edwards T, Camacho A,  et al.
2024-07-23 • Vaccines
2024-07-23 • Vaccines

During the 2018–2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of the Congo, were offered a two-dose prophylactic EVD vaccine. This was the first stud...

Journal Article
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Book Chapter

Building partnerships and confronting challenges: Implementation of an ebola virus vaccine clinical study during an outbreak in the Democratic Republic of the Congo

Bausch DG, Kavunga-Membo H, Grais RF, Imbault N, Roberts N,  et al.
2023-12-31 • Nephrology Dialysis Transplantation
2023-12-31 • Nephrology Dialysis Transplantation

Research, especially clinical trials, during outbreaks often poses enormous challenges, and up until very recent times was often considered almost impossible. However, for diseases su...

Journal Article
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Research

Protection, health seeking, or a laissez-passer: Participants’ decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo

James M, Kasereka JG, Kasiwa B, Kavunga-Membo H, Kambale K,  et al.
2023-03-15 • Social Science and Medicine
2023-03-15 • Social Science and Medicine
During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu. This prov...
Journal Article
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Research

Ebola Virus Disease in pregnancy: clinical, histopathologic and Immunohistochemical findings

Muehlenbachs A, de la Rosa Vazquez O, Bausch DG, Schafer IJ, Paddock C,  et al.
2016-05-25 • Journal of Infectious Diseases
2016-05-25 • Journal of Infectious Diseases
Here we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibu...
Journal Article
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Research

A standardised phase III clinical trial framework to assess therapeutic interventions for Lassa fever

Olayinka A, Bourner J, Akpede GO, Okoeguale J, Abejegah C,  et al.
2022-01-06 • PLOS Neglected Tropical Diseases
2022-01-06 • PLOS Neglected Tropical Diseases
BACKGROUND
Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is...
Journal Article
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Commentary

Overlooking the Importance of Immunoassays - Authors' Reply

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A,  et al.
2016-09-19 • Lancet Infectious Diseases
2016-09-19 • Lancet Infectious Diseases
Journal Article
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Review

Essentials of Filoviral Load Quantification

Cnops L, van Griensven J, Honko AN, Bausch DG, Sprecher A,  et al.
2016-06-10 • Lancet Infectious Diseases
2016-06-10 • Lancet Infectious Diseases
Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and in...
Journal Article
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Research

Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment

Colebunders R, Tshomba A, Van Kerkhove MD, Bausch DG, Campbell P,  et al.
2007-11-15 • Journal of Infectious Diseases
2007-11-15 • Journal of Infectious Diseases
The objective of the present study was to describe day of onset and duration of symptoms of Marburg hemorrhagic fever (MHF), to summarize the treatments applied, and to assess the qualit...
Journal Article
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Review

Sequelae of Ebola virus disease: the emergency within the emergency

Vetter P, Kaiser L, Schibler M, Ciglenecki I, Bausch DG
2016-03-22 • Lancet Infectious Diseases
2016-03-22 • Lancet Infectious Diseases
Journal Article
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Research

Clinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea

Brah E, Lamah MC, Fletcher TE, Jacob S, Brett-Major D,  et al.
2014-11-05 • New England Journal of Medicine
2014-11-05 • New England Journal of Medicine
Background In March 2014, the World Health Organization was notified of an outbreak of Zaire ebolavirus in a remote area of Guinea. The outbreak then spread to the capital, Conakry, and ...
Journal Article
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Letter

Evidence-based guidelines for supportive care of patients with Ebola virus disease

Lamontagne F, Fowler RA, Adhikari NK, Murthy S, Brett-Major D,  et al.
2017-10-17 • Lancet
2017-10-17 • Lancet
The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of p...
Protocol
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Research Protocol

Protocol for a phase 3 trial to evaluate the effectiveness and safety of a heterologous, two-dose vaccine for Ebola virus disease in the Democratic Republic of the Congo

Watson-Jones D, Kavunga-Membo H, Grais RF, Ahuka S, Roberts N,  et al.
2022-03-08 • BMJ Open
2022-03-08 • BMJ Open
INTRODUCTION
Ebola virus disease (EVD) continues to be a significant public health problem in sub-Saharan Africa, especially in the Democratic Republic of the Congo (DRC). Large-scal...
Journal Article
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Letter

Outbreaks in a rapidly changing Central Africa — lessons from Ebola

Munster VJ, Bausch DG, de Wit E, Fischer RJ, Kobinger GP,  et al.
2018-09-27 • New England Journal of Medicine
2018-09-27 • New England Journal of Medicine
Journal Article
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Research

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions

Bausch DG, Sprecher A, Jeffs B, Boumandouki P
2008-04-01 • Antiviral Research
2008-04-01 • Antiviral Research
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many ...