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Showing 1 - 20 of 30 Items
Showing 1 - 20 of 30 Items
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Journal Article
|
Research

Oral regimens for rifampin-resistant, fluoroquinolone-susceptible tuberculosis

Guglielmetti L, Khan U, Velásquez GE, Gouillou M, Abubakirov A,  et al.
2025-01-29 • New England Journal of Medicine
2025-01-29 • New England Journal of Medicine

BACKGROUND

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs ...

Journal Article
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Research

Effect of mass campaigns with full and fractional doses of pneumococcal conjugate vaccine (Pneumosil) on the reduction of nasopharyngeal pneumococcal carriage in Niger: a three-arm, open-label, cluster-randomised trial

Coldiron ME, Soumana I, Baudin E, Langendorf C, Mamiafo Tchoula C,  et al.
2025-01-08 • Lancet Infectious Diseases
2025-01-08 • Lancet Infectious Diseases

BACKGROUND

In settings with low pneumococcal conjugate vaccine (PCV) coverage, multi-age cohort mass campaigns could increase population immunity, and fractiona...

Conference Material
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Abstract

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a new tool for disease elimination

Baudin E, Mordt OV, Alves D, Seixas J, Lemerani M,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
Trypanosoma brucei rhodesiense human African trypanosomiasis (r-HAT), the zoonotic, acute form of sleeping sickness in eastern Africa, is lethal if untreated. Today, onl...
Conference Material
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Video

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense: a new tool for disease elimination

Baudin E
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Slide Presentation

Towards an arsenic-free oral treatment for human African trypanosomiasis due to Trypanosoma brucei rhodesiense a new tool for disease elimination

Baudin E, Mordt OV, Alves D, Seixas J, Lemerani M,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Journal Article
|
Research

Nine-month, all-oral regimens for rifampin-resistant tuberculosis

Guglielmetti L, Khan U, Velasquez GE, Gouillou M, Abubakirov A,  et al.
2024-01-29 • medRxiv
2024-01-29 • medRxiv

BACKGROUND

Aft...

Journal Article
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Protocol

Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial

Patil SB, Tamirat M, Khazhidinov K, Ardizzoni E, Atger M,  et al.
2023-11-30 • Trials
2023-11-30 • Trials
BACKGROUND
Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yi...
Technical Report
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Evidence Brief

The magnitude and severity of abortion-related complications: Referral Hospital in Jigawa State, a fragile setting - Results of the AMoCo study

Fotheringham C, Moore AM, Owolabi OO, Fetters T, Chen H,  et al.
2023-08-01
2023-08-01

A dearth of evidence on abortion complications in fragile settings limits the understanding of women’s needs in access to comprehensive abortion care in contexts like Jigawa state. Th...

Technical Report
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Evidence Brief

Knowledge, attitudes, practices, and behaviors among providers of abortion-related care. Castors maternity in Bangui, Central African Republic, a conflict-affected urban setting - Results of the AMoCo study

Powell B, Chen H, Pasquier E, Fetters T, Owolabi OO,  et al.
2023-07-01
2023-07-01
Conference Material
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Slide Presentation

High severity of abortion complications in fragile and conflict-affected settings: AMoCo, a mixed-methods cross-sectional study in two referral hospitals in sub-Saharan Africa

Pasquier E, Lissouba P, Chen H, Williams TN, Baudin E,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
Journal Article
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Pre-Print

Lessons learned conducting abortion research in fragile contexts: Reflections from a mixed methods study in Africa (the AMoCo study)

Moore AM, Pasquier E, Williams TN, Fetters T, Powell B,  et al.
2023-03-20 • Research Square
2023-03-20 • Research Square
BACKGROUND
Conducting abortion research in fragile settings presents challenges, many of which are present in other low-resourced settings to various degrees but when appearing all t...
Journal Article
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Research

High severity of abortion complications in fragile and conflict-affected settings: a cross-sectional study in two referral hospitals in sub-Saharan Africa (AMoCo study)

Pasquier E, Owolabi OO, Fetters T, Ngbale RN, Adame Gbanzi MC,  et al.
2023-03-04 • BMC Pregnancy and Childbirth
2023-03-04 • BMC Pregnancy and Childbirth
BACKGROUND
Abortion-related complications are one of the five main causes of maternal mortality. However, research about abortion is very limited in fragile and conflict-affected set...
Technical Report
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Evidence Brief

The magnitude and severity of abortion-related complications in the Castors Maternity in Bangui, Central African Republic – Evidence brief, March 2022

Pasquier E, Owolabi OO, Fetters T, Chen H, Williams TN,  et al.
2022-08-30
2022-08-30
Abortion complications remain a major cause of maternal mortality worldwide and abortion-related mortality has decreased very little over the last decade, unlike maternal mortality linke...
Journal Article
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Research

Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

Bonnet MMB, Bhatt NB, Baudin E, Silva C, Michon C,  et al.
2013-04-01 • Lancet Infectious Diseases
2013-04-01 • Lancet Infectious Diseases
BACKGROUND
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antitube...
Journal Article
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Research

Severe acute malnutrition results in lower lumefantrine exposure in children treated with artemether-lumefantrine for uncomplicated malaria

Chotsiri P, Denoeud-Ndam L, Baudin E, Guindo O, Diawara H,  et al.
2019-06-01 • Clinical Pharmacology & Therapeutics
2019-06-01 • Clinical Pharmacology & Therapeutics
Severe acute malnutrition (SAM) has been reported to be associated with increased malaria morbidity in Sub‐Saharan African children and may affect the pharmacology of antimalarial drugs....
Journal Article
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Research

Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia

Schramm B, Valeh P, Baudin E, Mazinda CS, Smith R,  et al.
2013-07-17 • Malaria Journal
2013-07-17 • Malaria Journal
BACKGROUND
Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.<...
Journal Article
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Research

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q,  et al.
2020-02-25 • BMC Medicine
2020-02-25 • BMC Medicine
BACKGROUND
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquin...
Protocol
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Research Protocol

Abortion-related Morbidity and Mortality in Conflict-affected and fragile settings (AMoCo Study)

Pasquier E, Fetters T, Owolabi OO, Moore AM, Marquer C,  et al.
2020-12-15
2020-12-15
OVERALL AIM
To describe and estimate the burden of abortion-related complications, particularly near-miss complications and deaths, and their associated factors among women presentin...
Journal Article
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Research

Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome

Bonnet MMB, Baudin E, Jani IV, Nunes E, Verhoustraeten F,  et al.
2013-12-18 • PLOS One
2013-12-18 • PLOS One
OBJECTIVES AND DESIGN
We used data from a randomized trial of HIV-tuberculosis co-infected patients in Mozambique to determine the incidence and predictors of paradoxical tuberculosi...
Journal Article
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Pre-Print

Early assessment of antiretroviral efficacy is critical to prevent the emergence of resistance mutations in HIV-tuberculosis coinfected patients: a substudy of the CARINEMO-ANRS12146 trial

Baudin E, Bhatt NB, Rouzioux C, Serafini M, Molfino L,  et al.
2019-02-08 • F1000Research
2019-02-08 • F1000Research
BACKGROUND
In the CARINEMO ANRS 12146 clinical trial, HIV-tuberculosis co-infected patients in Mozambique were randomized to nevirapine (NVP) or to efavirenz (EFV)-based antiretrovir...