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Showing 1 - 20 of 73 Items
Showing 1 - 20 of 73 Items
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Journal Article
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Research

Diagnostic performance and kinetics of hepatitis E viral RNA and IgM antibody test positivity in a genotype 1 outbreak in South Sudan

Koyuncu A, Nesbitt R, Alvarez C, Asilaza KV, Wamala J,  et al.
2025-08-14 • Journal of Infectious Diseases
2025-08-14 • Journal of Infectious Diseases

BACKGROUND

Diagnostics are essential for understanding hepatitis E epidemiology, but the field performanc...

Journal Article
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Review
Conference Material
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Poster

The field performance of hepatitis E diagnostics during an outbreak in Bentiu, South Sudan

Koyuncu A, Nesbitt R, Alvarez C, 
Conference Material
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Poster

Dry blood spots as a practical alternative for confirming hepatitis E

Azman AS, Nesbitt R, Alvarez C, Asilaza KV, Wamala J,  et al.
2025-05-22 • MSF Scientific Days International 2025
Journal Article
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Research
Journal Article
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Research
Journal Article
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Research
Journal Article
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Short Report
Conference Material
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Poster
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Slide Presentation
Conference Material
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Slide Presentation
Conference Material
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Abstract
Conference Material
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Abstract
Journal Article
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Research
Journal Article
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Research
Conference Material
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Abstract
Conference Material
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Poster
Conference Material
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Slide Presentation
Journal Article
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Letter
Journal Article
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Research

Protection from killed whole-cell cholera vaccines: a systematic review and meta-analysis

Xu H, Tiffany A, Luquero FJ, Kanungo S, Bwire G,  et al.
2025-07-13 • Lancet Global Health
2025-07-13 • Lancet Global Health

BACKGROUND

Killed whole-cell oral cholera vaccines (kOCVs) are a standard prevention and control measure in cholera-endemic areas and during outbreaks and human...

Asilaza KV, 
Wamala J, 
et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025

High confidence and demand for hepatitis E vaccine during an outbreak in Bentiu, South Sudan: A qualitative study

Koyuncu A, Asilaza KV, Rumunu J, Wamala J, Gitahi P,  et al.
2025-03-06 • PLOS Global Public Health
2025-03-06 • PLOS Global Public Health

In 2021 in response to an outbreak of hepatitis E in Bentiu internally displaced persons camp the South Sudanese Ministry of Health with support from Médecins Sans Frontières implemen...

The effectiveness of two doses of recombinant hepatitis E vaccine in response to an outbreak in Bentiu, South Sudan: a case–control and bias indicator study

Nesbitt RC, Kinya Asilaza V, Alvarez C, Gitahi P, Nkemenang P,  et al.
2025-01-08 • Lancet Infectious Diseases
2025-01-08 • Lancet Infectious Diseases

BACKGROUND

Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis, particularly in Asia and Africa, where HEV genotypes 1 and 2 are prevalen...

Safety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan

Nesbitt RC, Azman AS, Asilaza VK, Edwards JK, Gitahi P,  et al.
2024-11-01 • Lancet Global Health
2024-11-01 • Lancet Global Health

Spatiotemporal modeling of cholera, Uvira, Democratic Republic of the Congo, 2016−2020

Ratnayake R, Knee J, Cumming O, Saidi JM, Rumedeka BB,  et al.
2024-08-01 • Emerging Infectious Diseases
2024-08-01 • Emerging Infectious Diseases

We evaluated the spatiotemporal clustering of rapid diagnostic test−positive cholera cases in Uvira, eastern Democratic Republic of the Congo. We detected spatiotemporal clusters that...

A multi-site pilot study of the deployment of cholera rapid diagnostic tests in the Democratic Republic of the Congo

Moser W, Broban A, Welo PO, Mukadi D, Gerstl S,  et al.
2024-05-23 • Epicentre Scientific Day 2024
2024-05-23 • Epicentre Scientific Day 2024

Case-area targeted interventions to rapidly contain the spread of cholera - a prospective observational study in the Democratic Republic of the Congo

Finger F, Mimbu N, Ratnayake R, Meakin S, Bahati JB,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024

Safety of hepatitis E vaccine in pregnancy: emulating a target trial following a mass reactive vaccination campaign in South Sudan

Nesbitt R, Azman AS, Asilaza VK, Edwards JK, Nkemenang P,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024

Case-area targeted interventions to rapidly contain the spread of cholera: a prospective observational study in the Democratic Republic of the Congo

Finger F, Mimbu N, Ratnayake R, Meakin S, Bahati JB,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
The risk of cholera outbreaks spreading rapidly and extensively is substantial. Case-area targeted interventions (CATI) are based on the premise that early detection can...

Safety of hepatitis E vaccine in pregnancy: emulating a target trial following a mass reactive vaccination campaign in South Sudan

Nesbitt R, Azman AS, Asilaza VK, Edwards JK, Nkemenang P,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024

INTRODUCTION

Hepatitis E causes high mortality among pregnant women, with case fatality risks over 30% and adverse fetal outcomes. There is an evidence gap on the safety of the ...

Cholera deaths during outbreaks in Uvira, Eastern Democratic Republic of the Congo, 10-35 months after mass vaccination

Bugeme PM, Xu H, Hutchins C, Dent J, Saidi JM,  et al.
2024-02-01 • Open Forum Infectious Diseases
2024-02-01 • Open Forum Infectious Diseases
Our understanding of the burden and drivers of cholera mortality is hampered by limited surveillance and confirmation capacity. Leveraging enhanced clinical and laboratory surveillance i...

Vaccination coverage and adverse events following a reactive vaccination campaign against hepatitis E in Bentiu displaced persons camp, South Sudan

Nesbitt RC, Asilaza VK, Gignoux EM, Koyuncu A, Gitahi P,  et al.
2024-01-22 • PLOS Neglected Tropical Diseases
2024-01-22 • PLOS Neglected Tropical Diseases

INTRODUCTION

Hepatitis E (HEV) genotypes 1 and 2 are the common cause of jaundice and acute viral hepatitis that can cause large-scale outbreaks. HEV infection...

Two-dose vaccine effectiveness following the first reactive mass vaccination campaign against hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
INTRODUCTION
A three-dose recombinant vaccine against hepatitis E, Hecolin, has been licensed for use in China since 2011. While not recommended for routine use due to lack of eviden...

Vaccination coverage and adverse events following immunisation after the first reactive mass vaccination campaign against Hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023

Two-dose vaccine effectiveness following the first reactive mass vaccination campaign against Hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023

Hepatitis E virus outbreak among Tigray War refugees from Ethopia, Sudan

Azman AS, Gignoux E, Nesbitt R, Rumunu J, Aggarwal R,  et al.
2023-02-01 • Emerging Infectious Diseases
2023-02-01 • Emerging Infectious Diseases

Cholera outbreaks in sub-Saharan Africa during 2010-2019: a descriptive analysis

Zheng Q, Luquero FJ, Ciglenecki I, Wamala JF, Abubakar A,  et al.
2022-09-01 • International Journal of Infectious Diseases
2022-09-01 • International Journal of Infectious Diseases
BACKGROUND
Cholera remains a public health threat but is inequitably distributed across sub-Saharan Africa. Lack of standardized reporting and inconsistent outbreak definitions limit...