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Showing 1 - 20 of 69 Items
Showing 1 - 20 of 69 Items
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Journal Article
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Research

High confidence and demand for hepatitis E vaccine during an outbreak in Bentiu, South Sudan: A qualitative study

Koyuncu A, Asilaza KV, Rumunu J, Wamala J, Gitahi P,  et al.
2025-03-06 • PLOS Global Public Health
2025-03-06 • PLOS Global Public Health

In 2021 in response to an outbreak of hepatitis E in Bentiu internally displaced persons camp the South Sudanese Ministry of Health with support from Médecins Sans Frontières implemen...

Journal Article
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Research

The effectiveness of two doses of recombinant hepatitis E vaccine in response to an outbreak in Bentiu, South Sudan: a case–control and bias indicator study

Nesbitt RC, Kinya Asilaza V, Alvarez C, Gitahi P, Nkemenang P,  et al.
2025-01-08 • Lancet Infectious Diseases
2025-01-08 • Lancet Infectious Diseases

BACKGROUND

Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis, particularly in Asia and Africa, where HEV genotypes 1 and 2 are prevalen...

Journal Article
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Research

Safety of hepatitis E vaccine in pregnancy: an emulated target trial following a mass reactive vaccination campaign in Bentiu internally displaced persons camp, South Sudan

Nesbitt RC, Azman AS, Asilaza VK, Edwards JK, Gitahi P,  et al.
2024-11-01 • Lancet Global Health
2024-11-01 • Lancet Global Health
Journal Article
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Short Report

Spatiotemporal modeling of cholera, Uvira, Democratic Republic of the Congo, 2016−2020

Ratnayake R, Knee J, Cumming O, Saidi JM, Rumedeka BB,  et al.
2024-08-01 • Emerging Infectious Diseases
2024-08-01 • Emerging Infectious Diseases

We evaluated the spatiotemporal clustering of rapid diagnostic test−positive cholera cases in Uvira, eastern Democratic Republic of the Congo. We detected spatiotemporal clusters that...

Conference Material
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Poster

A multi-site pilot study of the deployment of cholera rapid diagnostic tests in the Democratic Republic of the Congo

Moser W, Broban A, Welo PO, Mukadi D, Gerstl S,  et al.
2024-05-23 • Epicentre Scientific Day 2024
2024-05-23 • Epicentre Scientific Day 2024
Conference Material
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Slide Presentation

Case-area targeted interventions to rapidly contain the spread of cholera - a prospective observational study in the Democratic Republic of the Congo

Finger F, Mimbu N, Ratnayake R, Meakin S, Bahati JB,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Slide Presentation

Safety of hepatitis E vaccine in pregnancy: emulating a target trial following a mass reactive vaccination campaign in South Sudan

Nesbitt R, Azman AS, Asilaza VK, Edwards JK, Nkemenang P,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
Conference Material
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Abstract

Case-area targeted interventions to rapidly contain the spread of cholera: a prospective observational study in the Democratic Republic of the Congo

Finger F, Mimbu N, Ratnayake R, Meakin S, Bahati JB,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024
INTRODUCTION
The risk of cholera outbreaks spreading rapidly and extensively is substantial. Case-area targeted interventions (CATI) are based on the premise that early detection can...
Conference Material
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Abstract

Safety of hepatitis E vaccine in pregnancy: emulating a target trial following a mass reactive vaccination campaign in South Sudan

Nesbitt R, Azman AS, Asilaza VK, Edwards JK, Nkemenang P,  et al.
2024-05-16 • MSF Scientific Day International 2024
2024-05-16 • MSF Scientific Day International 2024

INTRODUCTION

Hepatitis E causes high mortality among pregnant women, with case fatality risks over 30% and adverse fetal outcomes. There is an evidence gap on the safety of the ...

Journal Article
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Research

Cholera deaths during outbreaks in Uvira, Eastern Democratic Republic of the Congo, 10-35 months after mass vaccination

Bugeme PM, Xu H, Hutchins C, Dent J, Saidi JM,  et al.
2024-02-01 • Open Forum Infectious Diseases
2024-02-01 • Open Forum Infectious Diseases
Our understanding of the burden and drivers of cholera mortality is hampered by limited surveillance and confirmation capacity. Leveraging enhanced clinical and laboratory surveillance i...
Journal Article
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Research

Vaccination coverage and adverse events following a reactive vaccination campaign against hepatitis E in Bentiu displaced persons camp, South Sudan

Nesbitt RC, Asilaza VK, Gignoux EM, Koyuncu A, Gitahi P,  et al.
2024-01-22 • PLOS Neglected Tropical Diseases
2024-01-22 • PLOS Neglected Tropical Diseases

INTRODUCTION

Hepatitis E (HEV) genotypes 1 and 2 are the common cause of jaundice and acute viral hepatitis that can cause large-scale outbreaks. HEV infection...

Conference Material
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Abstract

Two-dose vaccine effectiveness following the first reactive mass vaccination campaign against hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
INTRODUCTION
A three-dose recombinant vaccine against hepatitis E, Hecolin, has been licensed for use in China since 2011. While not recommended for routine use due to lack of eviden...
Conference Material
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Poster

Vaccination coverage and adverse events following immunisation after the first reactive mass vaccination campaign against Hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
Conference Material
|
Slide Presentation

Two-dose vaccine effectiveness following the first reactive mass vaccination campaign against Hepatitis E in Bentiu, South Sudan

Nesbitt RC, Rumunu J, Asilaza VK, Gitahi P, Nkemenang P,  et al.
2023-06-07 • MSF Scientific Day International 2023
2023-06-07 • MSF Scientific Day International 2023
Journal Article
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Letter

Hepatitis E virus outbreak among Tigray War refugees from Ethopia, Sudan

Azman AS, Gignoux E, Nesbitt R, Rumunu J, Aggarwal R,  et al.
2023-02-01 • Emerging Infectious Diseases
2023-02-01 • Emerging Infectious Diseases
Journal Article
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Research

Cholera outbreaks in sub-Saharan Africa during 2010-2019: a descriptive analysis

Zheng Q, Luquero FJ, Ciglenecki I, Wamala JF, Abubakar A,  et al.
2022-09-01 • International Journal of Infectious Diseases
2022-09-01 • International Journal of Infectious Diseases
BACKGROUND
Cholera remains a public health threat but is inequitably distributed across sub-Saharan Africa. Lack of standardized reporting and inconsistent outbreak definitions limit...
Journal Article
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Letter

The first reactive vaccination campaign against hepatitis E

Ciglenecki I, Rumunu J, Wamala JF, Nkemenang P, Duncker J,  et al.
2022-08-01 • Lancet Infectious Diseases
2022-08-01 • Lancet Infectious Diseases
Protocol
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Research Protocol

Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study

Ratnayake R, Peyraud N, Ciglenecki I, Gignoux EM, Lightowler M,  et al.
2022-07-06 • BMJ Open
2022-07-06 • BMJ Open
INTRODUCTION
Cholera outbreaks in fragile settings are prone to rapid expansion. Case-area targeted interventions (CATIs) have been proposed as a rapid and efficient response strateg...
Journal Article
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Research

Successive epidemic waves of cholera in South Sudan between 2014 and 2017: a descriptive epidemiological study

Jones FK, Wamala JF, Rumunu J, Mawien PN, Kol MT,  et al.
2020-12-01 • Lancet Planetary health
2020-12-01 • Lancet Planetary health
Background
Between 2014 and 2017, successive cholera epidemics occurred in South Sudan within the context of civil war, population displacement, flooding, and drought. We aim to des...
Journal Article
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Letter

Single-dose oral cholera vaccine in Bangladesh

Azman AS, Luquero FJ
2016-08-18 • New England Journal of Medicine
2016-08-18 • New England Journal of Medicine