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Journal Article > Research

Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis

Palomino JC, Martin AIC, Von Groll A, Portaels F
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Abstract
Tuberculosis still represents a major public health problem, especially in low-resource countries where the burden of the disease is more important. Multidrug-resistant and extensively drug drug-resistant tuberculosis constitute serious problems for the efficient control of the disease stressing the need to investigate resistance to first- and second-line drugs. Conventional methods for detecting drug-resistance in Mycobacterium tuberculosis are slow and cumbersome. The most commonly used proportion method on Löwenstein-Jensen medium or Middlebrook agar requires a minimum of 3-4 weeks to produce results. Several new approaches have been proposed in the last years for the rapid and timely detection of drug-resistance in tuberculosis. This review will address phenotypic culture-based methods for rapid drug susceptibility testing in M. tuberculosis.
Subject Area
tuberculosis
DOI
10.1016/j.mimet.2008.06.015
Published Date
01-Oct-2008
PubMed ID
18627779
Languages
English
Journal
Journal of Microbiological Methods
Volume / Issue / Pages
Volume 75, Issue 2
Issue Date
01-Oct-2008
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