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Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children

Delmas V, Vasiliu A, Tchakounté Youngui B, Ssekyanzi B, Kuate Kuate A, Turyahabwe S, Simo L, Okello R, Casenghi M, Tchounga B, Atwine D, Cuer B, Bonnet M

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Abstract

BACKGROUND

The ‘CaP-TB’ project enhanced paediatric TB care through decentralized services, including screening, specimen collection, chest X-rays and implementation of the three-month rifampicin-isoniazid regimen for TB preventive treatment (TPT). In Cameroon and Uganda, it also included community-based child contact management through the ‘CONTACT’ study. We assessed the impact of CaP-TB project on TB detection and TPT outcomes in children, focusing on facilities included in ‘CONTACT’ study.


METHODS

Using a before-after design with aggregated data, we compared the proportion of children among all notified TB patients and the TPT completion rate for child contacts <5 years old between a pre- (March 2018–March 2019) and per-intervention (September 2020–September 2021) periods. During the intervention, half of the facilities implemented community-based child contact management.


RESULTS

The proportion of children among all notified TB patients increased from 4.8% (113/2373) to 11% (276/2512) during the intervention (odds ratio [OR] = 2.25, 95% confidence interval [CI]: 1.79–2.84). The number of children initiated on TPT increased from 105 to 841 and TPT completion rate from 55.2% (58/105) to 94.9% (798/841), (OR = 33.4, CI: 16.39–68.06).


CONCLUSION

Decentralizing and strengthening diagnosis and contact management can help overcome barriers to effective TB detection and TPT coverage in children.

Countries

Cameroon Uganda

Subject Area

tuberculosisdiagnosticspediatrics

Languages

English
DOI
10.5588/ijtld.24.0573
Published Date
27 Jun 2025
PubMed ID
40579765
Journal
International Journal of Tuberculosis and Lung Disease
Volume | Issue | Pages
Volume 29, Issue 7, Pages 312-317
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