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A cluster randomized non-inferiority field trial on the immunogenicity and safety of tetanus toxoid vaccine kept in controlled temperature chain compared to cold chain | Journal Article / Research | MSF Science Portal
Journal Article
|Research

A cluster randomized non-inferiority field trial on the immunogenicity and safety of tetanus toxoid vaccine kept in controlled temperature chain compared to cold chain

Juan-Giner A, Domicent C, Langendorf C, Roper M, Baoundoh P, Fermon F, Gakima P, Zipursky S, Tamadji M, Grais RF
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Abstract
In resource-poor settings, cold chain requirements present barriers for vaccine delivery. We evaluated the immunogenicity and safety of tetanus toxoid (TT) vaccine in "Controlled Temperature Chain" (CTC; up to 40°C for <30 days before administration), compared to standard cold chain (SCC; 2-8°C). Prior to the study, stability parameters of TT-CTC were shown to meet international requirements.

Countries

Chad

Subject Area

vaccination

Languages

English
DOI
10.1016/j.vaccine.2014.09.027
Published Date
23 Sep 2014
PubMed ID
25261378
Journal
Vaccine
Volume | Issue | Pages
Volume 32, Issue 47
Issue Date
2014-10-01
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