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Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger

Sands K, Lankapalli AK, Lai G, Hassan B, Portal EA, Mathias JA, Boostrom I, Li M, Cook K, Premchand-Branker S, Jones LS, Sayinzonga-Makombe N, Isanaka S, Kanapathipillai R, Mambula C, Mouniaman I, Langendorf C, Walsh TR, Spiller OB
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Abstract

Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here, we investigate carriage of Gram-negative bacteria in children under five years of age receiving treatment for SAM in Niger, comparing the frequency of colonisation with bacteria carrying resistance genes at admission, during hospital stay and at discharge. E. coli isolates carrying a blaNDM-5 gene were selected for whole-genome sequencing. Rectal colonisation with bacteria carrying ß-lactamase genes is high, with 76% (n = 1042/1371) of children harbouring bacteria carrying a blaCTXM-1-group gene and 25% (n = 338/1371) carrying a blaNDM-5 gene. Over two-thirds of children who did not carry bacteria with a carbapenemase gene at admission are colonised with bacteria carrying a carbapenemase gene at discharge (n = 503/729, 69%). E. coli ST167 carrying blaNDM-5 gene is recovered from 11% (n = 144/1371) of children. Here we highlight infection control and bacterial AMR transmission concerns amongst a vulnerable population in need of medical treatment.

Countries

Niger

Subject Area

antibiotic resistancepediatricsgenetics & genomicsmalnutritionsevere acute malnutritionantimicrobial resistance

Languages

English
DOI
10.1038/s41467-025-61718-w
Published Date
01 Aug 2025
PubMed ID
40750762
Journal
Nature Communications
Volume | Issue | Pages
Volume 16, Issue 1
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