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Ebola Virus Disease in pregnancy: clinical, histopathologic and Immunohistochemical findings | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Ebola Virus Disease in pregnancy: clinical, histopathologic and Immunohistochemical findings

Muehlenbachs A, de la Rosa Vazquez O, Bausch DG, Schafer IJ, Paddock C, Nyakio JP, Lame P, Bergeron E, McCollum AM, Goldsmith CS, Bowllweg BC, Prieto MA, Lushima RS, Ilunga BK, Nichol ST, Shieh WJ, Stroher U, Rollin PE, Zaki SR

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Abstract
Here we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibugyo virus had a livebirth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemistry, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malaria pigment-laden macrophages. These data suggest trophoblast infection may be a mechanism of transplacental ebolavirus transmission.

Countries

Democratic Republic of Congo Uganda

Subject Area

Ebolalaboratory

Languages

English
DOI
10.1093/infdis/jiw206
Published Date
25 May 2016
PubMed ID
27226206
Journal
Journal of Infectious Diseases
Volume | Issue | Pages
Volume 215, Issue 1, Pages 64–69
Issue Date
2016-05-25
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