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Using Simulation to Aid Trial Design: Ring-Vaccination Trials | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Using Simulation to Aid Trial Design: Ring-Vaccination Trials

Hitchings MD, Grais RF, Lipsitch M
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Abstract
The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.

Subject Area

vaccination

Languages

English
Published Date
22 Mar 2017
PubMed ID
28328984
Journal
PLOS Neglected Tropical Diseases
Volume | Issue | Pages
Volume null Issue 3
Issue Date
2017-03-22