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Journal Article > Research

Five-year field results and long-term effectiveness of 20 mg/kg liposomal amphotericin B (Ambisome) for visceral leishmaniasis in Bihar, India

Burza S, Sinha PK, Mahajan R, Lima MA, Mitra G, Verma N, Balasegaram M, Das P
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Abstract
Visceral Leishmaniasis (VL; also known as Kala-azar) is an ultimately fatal disease endemic in Bihar. A 2007 observational cohort study in Bihar of 251 patients with VL treated with 20 mg/Kg intravenous liposomal amphotericin B (Ambisome) demonstrated a 98% cure rate at 6-months. Between July 2007 and August 2012, Médecins Sans Frontières (MSF) and the Rajendra Memorial Research Institute (RMRI) implemented a VL treatment project in Bihar, India-an area highly endemic for Leishmania donovani-using this regimen as first-line treatment.
Countries
India
Subject Area
neglected tropical diseaseskala azar
DOI
10.1371/journal.pntd.0002603
Published Date
02-Jan-2014
PubMed ID
24392168
Languages
English
Journal
PLOS Neglected Tropical Diseases
Volume / Issue / Pages
Volume 8, Issue 1, Pages e2603
Issue Date
02-Jan-2014
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