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Benefit of viral load testing for confirmation of immunological failure in HIV patients treated in rural Malawi | Journal Article / Research | MSF Science Portal
Journal Article
|Research

Benefit of viral load testing for confirmation of immunological failure in HIV patients treated in rural Malawi

Kanapathipillai R, McGuire M, Mogha R, Szumilin E, Heinzelmann A, Pujades-Rodriguez M
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Abstract
Objective  Viral load testing is used in the HIV programme of Chiradzulu, Malawi, to confirm the diagnosis of immunological failure to prevent unnecessary switching to second-line therapy. Our objective was to quantify the benefit of this strategy for management of treatment failure in a large decentralized HIV programme in Africa. Methods  Retrospective analysis of monitoring data from adults treated with first-line antiretroviral regimens for >1 year and meeting the WHO immunological failure criteria in an HIV programme in rural Malawi. The positive predictive value of using immunological failure criteria to diagnose virological failure (viral load >5000 copies/ml) was estimated. Results  Of the 227 patients with immunological failure (185 confirmed with a repeat CD4 measurement), 155 (68.2%) had confirmatory viral load testing. Forty-four (28.4%) had viral load >5000 copies/ml and 57 (36.8%) >1000 copies/ml. Positive predictive value was 28.4% (95% CI 21.4-36.2%). Repeat CD4 count testing showed that 41% of patients initially diagnosed with immunological failure did no longer meet failure criteria. Conclusions  Our results support the need for confirming all cases of immunological failure with viral load testing before switching to second-line ART to optimize the use of resources in developing countries.

Countries

Malawi

Subject Area

diagnosticsHIV/AIDS

Languages

English
DOI
10.1111/j.1365-3156.2011.02874.x
Published Date
01 Sep 2011
PubMed ID
21883726
Journal
Tropical Medicine and International Health
Volume | Issue | Pages
Volume 16, Issue 12
Issue Date
2011-09-01
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