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Showing 1 - 18 of 18 Items
Showing 1 - 18 of 18 Items
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Research

Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo

Brindle HE, Tetsa-Tata D, Edwards T, Choi EML, Kasonia K,  et al.
2025-05-02 • PLOS Global Public Health
2025-05-02 • PLOS Global Public Health

Clinical trials in settings with intermittent or non-existent internet and power connectivity, for example ...

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Interim results of the multi-site incidence study of Lassa fever in West Africa

Camacho A
2023-06-08 • Epicentre Scientific Day Paris 2023
2023-06-08 • Epicentre Scientific Day Paris 2023
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Evaluation of a decentralised model of care on case isolation and patient outcomes during the 2018–20 Ebola outbreak in the Democratic Republic of the Congo: a retrospective observational study

Barks PM, Camacho A, Newport T, Ribeiro F, Ahuka-Mundeke S,  et al.
2025-03-25 • Lancet Global Health
2025-03-25 • Lancet Global Health

Ebola disease: Bridging scientific discoveries and clinical application

Rojek A, Fieggen J, Apiyo P, Caluwaerts S, Fowler RA,  et al.
2024-12-01 • Lancet Infectious Diseases
2024-12-01 • Lancet Infectious Diseases

The west Africa Ebola disease epidemic (2014-16) marked a historic change of course for patient care during emerging infectious disease outbreaks. The epidemic response was a failure ...

Rapid decision algorithm for patient triage during Ebola outbreaks

Ardiet DL, Nsio J, Komanda G, Coulborn RM, Grellety E,  et al.
2024-11-01 • Emerging Infectious Diseases
2024-11-01 • Emerging Infectious Diseases

The low specificity of Ebola virus disease clinical signs increases the risk for nosocomial transmission to patients and healthcare workers during outbreaks. Reducing this risk requir...

Field evaluation of validity and feasibility of Pan-Lassa rapid diagnostic test for Lassa fever in Abakaliki, Nigeria: a prospective diagnostic accuracy study

Elsinga J, Sunyoto T, di Stefano L, Giorgetti PF, Kyi HA,  et al.
2024-09-01 • Lancet Infectious Diseases
2024-09-01 • Lancet Infectious Diseases

BACKGROUND 

Lassa fever is a viral haemorrhagic fever with few options for diagnosis and treatment; it...

An oral antiviral for Ebola disease

Sprecher A, Van Herp M
2024-03-15 • Science
2024-03-15 • Science
For those exposed to filovirus, such as Sudan virus and Ebola virus, a new study offers hope.

Factors associated with reliable contact tracing during the 2021 Ebola virus disease outbreak in Guinea

Keita M, Cherif IS, Polonsky JA, Boland ST, Kandako Y,  et al.
2024-02-19 • Journal of Epidemiology and Community Health
2024-02-19 • Journal of Epidemiology and Community Health

BACKGROUND

In 2021, an Ebola virus disease (EVD) outbreak was declared in Guinea, linked to persistent virus from the 2014–2016 West Africa Epidemic. This paper...

Perspectives on advancing countermeasures for Filovirus disease: Report from a multi-sector meeting

Sprecher A, Cross RW, Marzi A, Martins KA, Wolfe D,  et al.
2023-08-19 • Journal of Infectious Diseases
2023-08-19 • Journal of Infectious Diseases
Although there are now approved treatments and vaccines for Ebola virus disease (EVD), the case fatality of EVD remains unacceptably high even when treated with the newly approved therap...

Interim results of the multi-site incidence study of Lassa fever in West Africa

Camacho A
2023-06-08 • Epicentre Scientific Day Paris 2023
2023-06-08 • Epicentre Scientific Day Paris 2023
BACKGROUND
Lassa fever (LF), a haemorrhagic illness caused by the Lassa fever virus (LASV), is endemic in West Africa causing an estimated 300 000 to 500 000 cases and 5 000 fataliti...

A standardised phase III clinical trial framework to assess therapeutic interventions for Lassa fever

Olayinka A, Bourner J, Akpede GO, Okoeguale J, Abejegah C,  et al.
2022-01-06 • PLOS Neglected Tropical Diseases
2022-01-06 • PLOS Neglected Tropical Diseases
BACKGROUND
Only one recommendation currently exists for the treatment of Lassa fever (LF), which is ribavirin administered in conjunction with supportive care. This recommendation is...

Another form of Lassa fever? Early neurological symptoms and high mortality reveal differences in two outbreaks in Ebonyi State, Nigeria 2017–2019

Chika Igwenyi N, Harrison RE, Unigwe US, Psarra C, Onwe Ogah E,  et al.
2020-12-01 • International Journal of Infectious Diseases
2020-12-01 • International Journal of Infectious Diseases
BACKGROUND
Lassa fever (LF) is an acute viral haemorrhagic illness with various clinical manifestations. Neurological symptoms are not commonly present at the early stage of the dise...

Detection of Marburg virus disease in Guinea

Koundouno FR, Kafetzopoulou LE, Faye M, Renevey A, Soropogui B,  et al.
2022-06-30 • New England Journal of Medicine
2022-06-30 • New England Journal of Medicine

Lassa fever in pregnancy with a positive maternal and fetal outcome: A case report

Agboeze J, Nwali MI, Nwakpakpa E, Ogah OE, Onoh R,  et al.
2019-12-01 • International Journal of Infectious Diseases
2019-12-01 • International Journal of Infectious Diseases
BACKGROUND
The signs and symptoms of Lassa fever are initially indistinguishable from other febrile illnesses common in the tropics and complications of pregnancy. Surviving Lassa fe...

Filovirus hemorrhagic fever outbreak case management: a review of current and future treatment options

Roddy P, Colebunders R, Jeffs B, Palma PP, Van Herp M,  et al.
2011-11-01 • Journal of Infectious Diseases
2011-11-01 • Journal of Infectious Diseases
Testing an innovative therapy for filovirus hemorrhagic fever (FHF) in an outbreak setting may be years away. Moreover, beyond anecdotal evidence, little is known about best practice for...

Estimation of Rift Valley fever virus spillover to humans during the Mayotte 2018–2019 epidemic

Metras R, Edmunds WJ, Youssouffi C, Dommergues L, Fournié G,  et al.
2020-09-29 • Proceedings of the National Academy of Sciences
2020-09-29 • Proceedings of the National Academy of Sciences
Rift Valley fever (RVF) is an emerging, zoonotic, arboviral hemorrhagic fever threatening livestock and humans mainly in Africa. RVF is of global concern, having expanded its geographica...

Emergence of Zaire Ebola Virus Disease in Guinea - Preliminary Report

Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L,  et al.
2014-10-09 • New England Journal of Medicine
2014-10-09 • New England Journal of Medicine
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. ...

Infection control during filoviral hemorrhagic fever outbreaks: preferences of community members and health workers in Masindi, Uganda

Raabe VN, Mutyaba I, Roddy P, Lutwama J, Geissler W,  et al.
2010-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
2010-01-01 • Transactions of the Royal Society of Tropical Medicine and Hygiene
Interviews were conducted with health workers and community members in Masindi, Uganda on improving the acceptability of infection control measures used during an Ebola outbreak. Measure...