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Showing 1 - 11 of 11 Items
Showing 1 - 11 of 11 Items
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Journal Article
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Commentary

Disease-specific differences in pharmacokinetics of paromomycin and miltefosine between post-kala-azar dermal leishmaniasis and visceral leishmaniasis patients in eastern Africa

Chu WY, Verrest L, Younis BM, Musa AM, Mbui J,  et al.
2024-12-16 • Journal of Infectious Diseases
2024-12-16 • Journal of Infectious Diseases

Treatment regimens for post-kala-azar dermal leishmaniasis (PKDL) are usually extrapolated from those for visceral leishmaniasis (VL), but drug pharmacokinetics (PK) can differ due to...

Conference Material
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Poster

Optimizing nutrient supplementation among pregnant and reproductive age women in Kenya (VIRUTUBISHO)

Talbert A, Mwangome M, Berkley JA
2024-05-03 • MSF Paediatric Days 2024
2024-05-03 • MSF Paediatric Days 2024
Journal Article
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Research

Population pharmacokinetics of pediatric lopinavir/ritonavir oral pellets in children living with HIV in Africa

Chupradit S, Wamalwa DC, Maleche‐Obimbo E, Kekitiinwa AR, Mwanga‐Amumpaire J,  et al.
2024-05-01 • Clinical Pharmacology & Therapeutics
2024-05-01 • Clinical Pharmacology & Therapeutics
Antiretroviral therapy for children living with HIV (CLHIV) under 3 years of age commonly includes lopinavir/ritonavir (LPV/r). However, the original liquid LPV/r formulation has taste a...
Journal Article
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Research

Abacavir drug exposures in African children under 14 kg using paediatric solid fixed dose combinations according to World Health Organization weight bands

Chupradit S, Wamalwa DC, Maleche-Obimbo E, Kekitiinwa AR, Mwanga-Amumpaire J,  et al.
2023-10-05 • Journal of the Pediatric Infectious Diseases Society
2023-10-05 • Journal of the Pediatric Infectious Diseases Society
BACKGROUND
The pharmacokinetics of abacavir (ABC) in African children living with HIV (CLHIV) weighing < 14 kg and receiving pediatric fixed dose combinations (FDC) according to WHO ...
Journal Article
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Research

Population pharmacokinetics of a combination of miltefosine and paromomycin in Eastern African children and adults with visceral leishmaniasis

Verrest L, Roseboom IC, Wasunna M, Mbui J, Njenga SN,  et al.
2023-09-20 • Journal of Antimicrobial Chemotherapy
2023-09-20 • Journal of Antimicrobial Chemotherapy
OBJECTIVES
To improve visceral leishmaniasis (VL) treatment in Eastern Africa, 14- and 28-day combination regimens of paromomycin plus allometrically dosed miltefosine were evaluated...
Conference Material
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Video

Use of population pharmacokinetics to assess adherence to amodiaquine used for seasonal malaria chemoprevention

Coldiron ME
2020-05-13 • MSF Scientific Days International 2020: Research
2020-05-13 • MSF Scientific Days International 2020: Research
Journal Article
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Research

Adherence and population pharmacokinetic properties of amodiaquine when used for Seasonal Malaria Chemoprevention in African children

Ding J, Coldiron ME, Assao B, Guindo O, Blessborn D,  et al.
2019-10-25 • Clinical Pharmacology & Therapeutics
2019-10-25 • Clinical Pharmacology & Therapeutics
Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties of amodiaquine and...
Journal Article
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Research

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

Rao PS, Moore CC, Mbonde AA, Nuwagira E, Orikiriza P,  et al.
2021-06-18 • Antibiotics
2021-06-18 • Antibiotics
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to...
Conference Material
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Slide Presentation

Use of population pharmacokinetics to assess adherence to amodiaquine used for seasonal malaria chemoprevention

Coldiron ME
2020-05-13 • MSF Scientific Days International 2020: Research
2020-05-13 • MSF Scientific Days International 2020: Research
Conference Material
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Abstract

Use of population pharmacokinetics to assess adherence to amodiaquine used for seasonal malaria chemoprevention

Ding J, Coldiron ME, Assao B, Guindo O, Blessborn D,  et al.
2020-05-20 • MSF Scientific Days International 2020: Research
2020-05-20 • MSF Scientific Days International 2020: Research
INTRODUCTION
Seasonal malaria chemoprevention (SMC) has been widely implemented by MSF in the African Sahel. It consists of monthly courses of antimalarial drugs during the high-risk...
Protocol
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Research Protocol

Population pharmacokinetics and pharmacodynamics of investigational regimens' drugs in the TB-PRACTECAL clinical trial (the PRACTECAL-PKPD study): a prospective nested study protocol in a randomised controlled trial

Nyang'wa BT, Kloprogge F, Moore DAJ, Bustinduy A, Motta I,  et al.
2021-09-06 • BMJ Open
2021-09-06 • BMJ Open
INTRODUCTION
Drug-resistant tuberculosis (TB) remains a global health threat, with little over 50% of patients successfully treated. Novel regimens like the ones being studied in the...