Search Results | MSF Science Portal

Journal Article

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Editorial

Santos ALS, Rodrigues IA, d’Avila-Levy CM, Sodré CL, Ritmeijer KKD, et al.

2023-10-19 • Pathogens

Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (als...

Journal Article

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Research

Gobbi F, Angheben A, Anselmi M, Postiglione C, Repetto EC, et al.

2014-12-11 • PLOS Neglected Tropical Diseases

BACKGROUND
Chagas disease (CD) is endemic in Central and South America, Mexico and even in some areas of the United States. However, cases have been increasingly recorded also in no...

Journal Article

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Letter

Forsyth C, Marchiol A, Herazo R, Chatelain E, Batista C, et al.

2018-12-31 • Revista da Sociedade Brasileira de Medicina Tropical

Journal Article

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Research

Villa L, Morote S, Bernal O, Bulla D, Albajar Viñas P

2007-10-30 • Memorias do Instituto Oswaldo Cruz

In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course...

Journal Article

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Commentary

Porras AI, Yadon ZE, Altcheh J, Britto C, Chaves GC, et al.

2015-06-04 • PLOS Neglected Tropical Diseases

Journal Article

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Research

Yun O, Lima MA, Ellman T, Chambi W, Castillo S, et al.

2009-07-07 • PLOS Neglected Tropical Diseases

BACKGROUND:
Chagas disease (American trypanosomiasis) is a zoonotic or anthropozoonotic disease caused by the parasite Trypanosoma cruzi. Predominantly affecting populations in poor...

Journal Article

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Research

Parrado R, Ramirez JC, de la Barra A, Alonso-Vega C, Juiz N, et al.

2018-12-03 • Antimicrobial Agents and Chemotherapy

This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time PCR (qPCR) for baseline detection and quantification of parasitic loads and post-trea...

Journal Article

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Commentary

Hotez PJ, Dumonteil E, Cravioto MB, Bottazzi ME, Tapia-Conyer R, et al.

2013-10-31 • PLOS Neglected Tropical Diseases

Journal Article

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Research

Brum-Soares L, Cubides JC, Burgos I, Monroy C, Castillo L, et al.

2016-12-01 • Revista da Sociedade Brasileira de Medicina Tropical

INTRODUCTION
Geographical, epidemiological, and environmental differences associated with therapeutic response to Chagas etiological treatment have been previously discussed. This st...

Journal Article

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Research

Pane S, Giancola ML, Piselli P, Corpolongo A, Repetto EC, et al.

2018-05-08 • BMC Infectious Diseases

Chagas disease (CD) is a systemic parasitic infection caused by the protozoan Trypanosoma cruzi, whose chronic phase may lead to cardiac and intestinal disorders. Endemic in Latin Americ...

Journal Article

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Commentary

MSF Access Campaign

2007-06-01 • Revista da Sociedade Brasileira de Medicina Tropical

Trypanosoma cruzi infection is often not detected early on or actively diagnosed, partly because most infected individuals are either asymptomatic or oligosymptomatic. Moreover, in most ...

Journal Article

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Research

Repetto EC, Zachariah R, Kumar AMV, Angheben A, Gobbi F, et al.

2015-09-25 • PLOS Neglected Tropical Diseases

OBJECTIVES
Chagas disease (CD) represents a growing problem in Europe; Italy is one of the most affected countries but there is no national framework for CD and access-to-care is cha...

Journal Article

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Research

Antinori S, Galimberti L, Grande R, Bianco R, Oreni L, et al.

2018-03-16 • Clinical Microbiology and Infection

OBJECTIVES:
We aimed to assess the prevalence and risk factors for Chagas disease (CD) in Latin American immigrants and to evaluate the accuracy of diagnostic tests. Moreover, we of...

Journal Article

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Research

Ramirez JC, Parrado R, Sulleiro E, de la Barra A, Rodriguez M, et al.

2017-11-27 • PLOS One

Real-Time PCR (qPCR) testing is recommended as both a diagnostic and outcome measurement of etiological treatment in clinical practice and clinical trials of Chagas disease (CD), but no ...

Journal Article

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Research

Jannin J, Villa L

2007-10-30 • Memorias do Instituto Oswaldo Cruz

Chagas disease (American trypanosomiasis) is endemic in 21 countries of the Americas, where control is largely focused on elimination of the domestic insect vectors (Triatominae) coupled...

Journal Article

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Research

Escriba JM, Ponce E, Romero Ade D, Albajar Viñas P, Marchiol A, et al.

2009-11-01 • Memorias do Instituto Oswaldo Cruz

Between 1999-2002, Médécins Sans Frontières-Spain implemented a project seeking to determine the efficacy and safety of benznidazole in the treatment of recent chronic Chagas disease in ...

Journal Article

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Review

Pinheiro E, Brum-Soares L, Reis R, Cubides JC

2017-06-01 • Revista da Sociedade Brasileira de Medicina Tropical

After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health pr...

Journal Article

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Review

Forsyth C, Meymandi S, Moss I, Cone J, Cohen RM, et al.

2019-09-26 • PLOS Neglected Tropical Diseases

BACKGROUND
Chagas disease (CD) affects over 300,000 people in the United States, but fewer than 1% have been diagnosed and less than 0.3% have received etiological treatment. This is...

Journal Article

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Research

Sperandio da Silva G, Felix Mediano M, Hasslocher-Moreno A, Holanda M, Silvestre de Sousa A, et al.

2017-06-22 • Journal of Antimicrobial Chemotherapy

BACKGROUND
Up to half of patients with Chagas' disease under benznidazole treatment present adverse drug reactions (ADRs) and up to one-third do not complete standard treatment.
...

Journal Article

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Commentary

Picado A, Angheben A, Marchiol A, Alarcón de Noya B, Flevaud L, et al.

2017-01-05 • PLOS Neglected Tropical Diseases

Science Portal

Therapeutic strategies against leishmania and trypanosoma

Profile of Trypanosoma cruzi infection in a tropical medicine reference center, Northern Italy

Clinical practice guidelines for Chagas disease: recent developments and future needs

Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century

Target product profile (TPP) for Chagas disease point-of-care diagnosis and assessment of response to treatment

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières

Real-Time PCR for the Evaluation of Treatment Response in Clinical Trials of Adult Chronic Chagas Disease: Usefulness of Serial Blood Sampling and qPCR Replicates

An unfolding tragedy of Chagas disease in North America

High seroconversion rates in Trypanosoma cruzi chronic infection treated with benznidazole in people under 16 years in Guatemala

Serological evaluation for Chagas disease in migrants from Latin American countries resident in Rome, Italy

International meeting: new diagnostic tests are urgently needed to treat patients with Chaga's disease

Neglect of a neglected disease in Italy: the challenge of access-to-care for Chagas disease in Bergamo area

Chagas disease knocks on our door: a cross-sectional study among Latin American immigrants in Milan, Italy

First external Quality Assurance Program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease

An overview of Chagas disease treatment

Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras

Chagas Disease: Review of Needs, Neglect, and Obstacles to Treatment Access in Latin America

Proposed multidimensional framework for understanding Chagas disease healthcare barriers in the United States

Benznidazole treatment safety: The Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas' Disease

Development of diagnostics for Chagas disease: where should we put our limited resources?